CPT: Pharmacometrics and Systems Pharmacology

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Top Publications

• Timing of Antiviral Treatment Initiation is Critical to Reduce SARS-CoV-2 Viral Load.

  Antonio Gonçalves;Julie Bertrand;Ruian Ke;Emmanuelle Comets

  (2020)
  223 Citations

• Data Digitizing: Accurate and Precise Data Extraction for Quantitative Systems Pharmacology and Physiologically-Based Pharmacokinetic Modeling.

  Jan-Georg Wojtyniak;Jan-Georg Wojtyniak;Hannah Britz;Dominik Selzer;Matthias Schwab;Matthias Schwab

  (2020)
  73 Citations

• Perspective on model-informed drug development

  Lawrence J. Lesko

  (2021)
  45 Citations

• Mini-Review: Comprehensive Drug Disposition Knowledge Generated in the Modern Human Radiolabeled ADME Study

  (2020)
  43 Citations

• Covariate modeling in pharmacometrics: General points for consideration

  (2024)
  37 Citations

• Machine learning algorithms to estimate everolimus exposure trained on simulated and patient pharmacokinetic profiles

  (2022)
  36 Citations

• Multi‐model averaging improves the performance of model‐guided infliximab dosing in patients with inflammatory bowel diseases

  (2022)
  36 Citations

• Quantitative Systems Pharmacology for Neuroscience Drug Discovery and Development: Current Status, Opportunities, and Challenges.

  Hugo Geerts;John Wikswo;Piet H. van der Graaf;Jane P.F. Bai

  (2020)
  35 Citations

• Stable warfarin dose prediction in sub‐Saharan African patients: A machine‐learning approach and external validation of a clinical dose–initiation algorithm

  (2021)
  33 Citations

• Translational pharmacokinetic-pharmacodynamic modeling of preclinical and clinical data of the oral MET inhibitor tepotinib to determine the recommended phase II dose

  Wenyuan Xiong;Manja Friese‐Hamim;Andreas Johne;Christopher Stroh

  (2021)
  32 Citations

• Advancing drug safety science by integrating molecular knowledge with post‐marketing adverse event reports

  (2022)
  32 Citations

• Assessing the predictive performance of population pharmacokinetic models for intravenous polymyxin B in critically ill patients.

  Patrick O. Hanafin;Roger L. Nation;Marc H. Scheetz;Alexandre P. Zavascki

  (2021)
  31 Citations

• Robust physiologically based pharmacokinetic model of rifampicin for predicting drug–drug interactions via P‐glycoprotein induction and inhibition in the intestine, liver, and kidney

  (2022)
  29 Citations

• Modeling Favipiravir Antiviral Efficacy Against Emerging Viruses: From Animal Studies to Clinical Trials.

  Vincent Madelain;Sylvain Baize;Xavier Anglaret

  (2020)
  29 Citations

• Cluster Gauss‐Newton method analyses of PBPK model parameter combinations of coproporphyrin‐I based on OATP1B‐mediated rifampicin interaction studies

  (2022)
  28 Citations