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Chemistry

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Overview

Yukihiro Shoyama is affiliated with Nagasaki International University in Japan and works primarily in the fields of Biochemistry, Genetics and Molecular Biology, as well as Medicine. Their research output spans several subfields, including Molecular Biology, Pharmacology, Plant Science, Oncology, and Complementary and Alternative Medicine.

The scientist's work frequently focuses on the pharmacological effects of natural compounds, with an emphasis on biological effects and applications related to ginseng and saffron. Other main topics cover melanin and skin pigmentation, GABA and rice research, phytochemistry and biological activity of medicinal plants, and bioactive compounds derived from medicinal plants.

Shoyama has published research in various scientific journals. Frequent publication venues include:

  • Longhua Chinese Medicine
  • Antibodies
  • Journal of Natural Medicines
  • Biomedical Research
  • Planta Medica

Recent papers highlight different aspects of pharmacological natural product research:

  • "Costunolide and dehydrocostuslactone from Saussurea lappa root inhibit autophagy in hepatocellular carcinoma cells" (2020, Journal of Natural Medicines)
  • "Which East Asian herbal medicines can decrease viral infections?" (2021, Phytochemistry Reviews)
  • "De-Glycyrrhizinated Licorice Extract Attenuates High Glucose-Stimulated Renal Tubular Epithelial-Mesenchymal Transition via Suppressing the Notch2 Signaling Pathway" (2020, Cells)
  • "Effects of saffron and its active constituent crocin on cancer management: a narrative review" (2022, Longhua Chinese Medicine)
  • "(−)-Epigallocatechin-3-gallate inhibits RANKL-induced osteoclastogenesis via downregulation of NFATc1 and suppression of HO-1-HMGB1-RAGE pathway" (2020, Biomedical Research)

Shoyama collaborates frequently with several coauthors, including:

  • Takuhiro Uto
  • Tomoe Ohta
  • Kenny Kuchta
  • Shunsuke Fujii
  • Nguyễn Hữu Tùng

Best Publications

  • Enzyme-linked immunosorbent assay for the quantitative/qualitative analysis of plant secondary metabolites.

    Seiichi Sakamoto;Waraporn Putalun;Sornkanok Vimolmangkang;Waranyoo Phoolcharoen

  • The Gene Controlling Marijuana Psychoactivity: MOLECULAR CLONING AND HETEROLOGOUS EXPRESSION OF Δ1-TETRAHYDROCANNABINOLIC ACID SYNTHASE FROM CANNABIS SATIVA L. *

    Supaart Sirikantaramas;Satoshi Morimoto;Yoshinari Shoyama;Yu Ishikawa

  • Crocin prevents the death of rat pheochromyctoma (PC-12) cells by its antioxidant effects stronger than those of α-tocopherol

    Takashi Ochiai;Shigekazu Ohno;Shinji Soeda;Hiroyuki Tanaka

  • Protective effects of carotenoids from saffron on neuronal injury in vitro and in vivo.

    Takashi Ochiai;Hiroshi Shimeno;Ken ichi Mishima;Katsunori Iwasaki

  • Tetrahydrocannabinolic Acid Synthase, the Enzyme Controlling Marijuana Psychoactivity, is Secreted into the Storage Cavity of the Glandular Trichomes

    Supaart Sirikantaramas;Futoshi Taura;Yumi Tanaka;Yu Ishikawa

  • Cannabidiolic-acid synthase, the chemotype-determining enzyme in the fiber-type Cannabis sativa.

    Futoshi Taura;Supaart Sirikantaramas;Yoshinari Shoyama;Kazuyoshi Yoshikai

  • Purification and Characterization of Cannabidiolic-acid Synthase from Cannabis sativa L.: BIOCHEMICAL ANALYSIS OF A NOVEL ENZYME THAT CATALYZES THE OXIDOCYCLIZATION OF CANNABIGEROLIC ACID TO CANNABIDIOLIC ACID *

    Futoshi Taura;Satoshi Morimoto;Yukihiro Shoyama

  • First direct evidence for the mechanism of .DELTA.1-tetrahydrocannabinolic acid biosynthesis

    Futoshi Taura;Satoshi Morimoto;Yukihiro Shoyama;Raphael Mechoulam

  • Crocin suppresses tumor necrosis factor-α-induced cell death of neuronally differentiated PC-12 cells

    Shinji Soeda;Takashi Ochiai;Loungratana Paopong;Hiroyuki Tanaka

  • Effects of grapefruit juice and orange juice components on P-glycoprotein- and MRP2-mediated drug efflux.

    Yoko Honda;Fumihiko Ushigome;Noriko Koyabu;Satoshi Morimoto

  • Improvement of artemisinin production by chitosan in hairy root cultures of Artemisia annua L.

    Waraporn Putalun;Wanwimon Luealon;Wanchai De-Eknamkul;Hiroyuki Tanaka

  • Effect of furanocoumarin derivatives in grapefruit juice on the uptake of vinblastine by Caco-2 cells and on the activity of cytochrome P450 3A4

    Ayako Ohnishi;Hirotami Matsuo;Shiho Yamada;Hitomi Takanaga

  • Characterization of olivetol synthase, a polyketide synthase putatively involved in cannabinoid biosynthetic pathway

    Futoshi Taura;Shinji Tanaka;Chiho Taguchi;Tomohide Fukamizu

  • Crocin prevents the death of PC-12 cells through sphingomyelinase-ceramide signaling by increasing glutathione synthesis

    Takashi Ochiai;Shinji Soeda;Shigekazu Ohno;Hiroyuki Tanaka

  • Polymethoxylated flavones in orange juice are inhibitors of P-glycoprotein but not cytochrome P450 3A4.

    Hitomi Takanaga;Ayako Ohnishi;Shiho Yamada;Hirotami Matsuo

  • Structure and function of 1-tetrahydrocannabinolic acid (THCA) synthase, the enzyme controlling the psychoactivity of Cannabis sativa

    Yoshinari Shoyama;Taro Tamada;Kazuo Kurihara;Ayako Takeuchi

  • Purification and characterization of cannabichromenic acid synthase from Cannabis sativa.

    Satoshi Morimoto;Kengo Komatsu;Futoshi Taura;Yukihiro Shoyama

  • Enzyme-linked immunosorbent assay for glycyrrhizin using anti-glycyrrhizin monoclonal antibody and an eastern blotting technique for glucuronides of glycyrrhetic acid.

    Shaojie Shan;Hiroyuki Tanaka;Yukihiro Shoyama

  • Constituent properties of licorices derived from Glycyrrhiza uralensis, G. glabra, or G. inflata identified by genetic information.

    Kenji Kondo;Mao Shiba;Rie Nakamura;Takashi Morota

  • Endocannabinoid system modulates relapse to methamphetamine seeking: possible mediation by the arachidonic acid cascade.

    Kusnandar Anggadiredja;Masanori Nakamichi;Takato Hiranita;Hiroyuki Tanaka

Frequent Co-Authors

Hiroyuki Tanaka
Hiroyuki Tanaka Kyushu University
Satoshi Morimoto
Satoshi Morimoto Kyushu University
Itsuo Nishioka
Itsuo Nishioka Kyushu University
Chun-Su Yuan
Chun-Su Yuan University of Chicago
Michihiro Fujiwara
Michihiro Fujiwara Fukuoka University
Nobuo Ohta
Nobuo Ohta Tokyo Medical and Dental University
Shoji Yamaoka
Shoji Yamaoka Tokyo Medical and Dental University
Shigenori Watanabe
Shigenori Watanabe Kyushu University
Kazuho Abe
Kazuho Abe Musashino University
Norio Miura
Norio Miura Kyushu University

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