World's Best Scientists 2026 revealed!

Overview

Xun Gu is affiliated with Iowa State University in the United States and specializes in Biochemistry, Genetics, and Molecular Biology. Their body of work focuses on diverse topics such as Evolution and Genetic Dynamics, Bioinformatics and Genomic Networks, and Gene Expression and Cancer Classification. Additional research areas include Genomics and Phylogenetic Studies, Cancer Genomics and Diagnostics, Advancements in Transdermal Drug Delivery, and Immunotherapy and Immune Responses.

Their recent publications cover a range of scientific domains and include:

  • The Impact of DNA Methylation Dynamics on the Mutation Rate During Human Germline Development, 2020, published in G3 Genes Genomes Genetics
  • MODIG: integrating multi-omics and multi-dimensional gene network for cancer driver gene identification based on graph attention network model, 2022, published in Bioinformatics
  • Celecoxib nanocrystal-loaded dissolving microneedles with highly efficient for osteoarthritis treatment, 2022, published in International Journal of Pharmaceutics
  • Co-delivery of drugs by adhesive transdermal patches equipped with dissolving microneedles for the treatment of rheumatoid arthritis, 2023, published in Journal of Controlled Release
  • TSNAD v2.0: A one-stop software solution for tumor-specific neoantigen detection, 2021, published in Computational and Structural Biotechnology Journal

Xun Gu has collaborated frequently with other researchers. Notable coauthors include:

  • Zhan Zhou
  • Shuqing Chen
  • Wenyi Zhao
  • Yingying Li
  • Tao Ma

Their works are commonly published in specific scientific venues, including:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Journal of Molecular Evolution
  • International Journal of Pharmaceutics
  • SSRN Electronic Journal
  • Genomics Proteomics & Bioinformatics

Best Publications

  • Role of duplicate genes in genetic robustness against null mutations.

    Zhenglong Gu;Lars M. Steinmetz;Xun Gu;Curt Scharfe

  • Statistical methods for testing functional divergence after gene duplication.

    Xun Gu

  • Expression divergence between duplicate genes.

    Wen-Hsiung Li;Jing Yang;Xun Gu

  • DIVERGE: phylogeny-based analysis for functional–structural divergence of a protein family

    Xun Gu;Kent Vander Velden

  • Maximum-Likelihood Approach for Gene Family Evolution Under Functional Divergence

    Xun Gu

  • Age distribution of human gene families shows significant roles of both large- and small-scale duplications in vertebrate evolution.

    Xun Gu;Yufeng Wang;Yufeng Wang;Jianying Gu

  • A Simple Statistical Method for Estimating Type-II (Cluster-Specific) Functional Divergence of Protein Sequences

    Xun Gu

  • Rapid evolution of expression and regulatory divergences after yeast gene duplication.

    Xun Gu;Zhongqi Zhang;Wei Huang

  • Identification of conserved gene structures and carboxy-terminal motifs in the Myb gene family of Arabidopsis and Oryza sativa L. ssp. indica.

    Cizhong Jiang;Xun Gu;Thomas Peterson

  • An Update of DIVERGE Software for Functional Divergence Analysis of Protein Family

    Xun Gu;Xun Gu;Yangyun Zou;Zhixi Su;Wei Huang

  • Evolution of alternative splicing after gene duplication.

    Zhixi Su;Jianmin Wang;Jun Yu;Xiaoqiu Huang

  • Predicting functional divergence in protein evolution by site-specific rate shifts

    Eric A. Gaucher;Xun Gu;Michael M. Miyamoto;Steven A. Benner

  • Ordered origin of the typical two- and three-repeat Myb genes.

    Cizhong Jiang;Jianying Gu;Surinder Chopra;Xun Gu

  • Intron gain and loss in segmentally duplicated genes in rice

    Haining Lin;Wei Zhu;Joana C Silva;Xun Gu

  • Induced gene expression in human brain after the split from chimpanzee

    Jianying Gu;Xun Gu

  • Functional Divergence in the Caspase Gene Family and Altered Functional Constraints: Statistical Analysis and Prediction

    Yufeng Wang;Xun Gu

  • Statistical framework for phylogenomic analysis of gene family expression profiles.

    Xun Gu

  • TIR-Learner, a New Ensemble Method for TIR Transposable Element Annotation, Provides Evidence for Abundant New Transposable Elements in the Maize Genome.

    Weijia Su;Xun Gu;Thomas Peterson

  • The origin and evolution of enamel mineralization genes.

    Jean-Yves Sire;Tiphaine Davit-Béal;Sidney Delgado;Xun Gu

  • Functional divergence in protein (family) sequence evolution.

    Xun Gu

Frequent Co-Authors

C. Robin Buell
C. Robin Buell University of Georgia
Thomas Peterson
Thomas Peterson Iowa State University
Brian J. Haas
Brian J. Haas Broad Institute
Wen-Hsiung Li
Wen-Hsiung Li Academia Sinica
Blake C. Meyers
Blake C. Meyers University of California, Davis
Daniel F. Voytas
Daniel F. Voytas University of Minnesota
Jun Yu
Jun Yu Chinese University of Hong Kong
Sudhir Kumar
Sudhir Kumar Temple University
Ronald W. Davis
Ronald W. Davis Stanford University
Susan J. Lamont
Susan J. Lamont Iowa State University

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