Rüdiger Hardeland

Best Publications

• Melatonin: Nature's most versatile biological signal?

  S R Pandi-Perumal;V Srinivasan;G J M Maestroni;D P Cardinali

  1301
  Citations

• Melatonin—A pleiotropic, orchestrating regulator molecule

  Rüdiger Hardeland;Daniel P. Cardinali;Venkatramanujam Srinivasan;D. Warren Spence

  1019
  Citations

• Antioxidative protection by melatonin: multiplicity of mechanisms from radical detoxification to radical avoidance.

  Rüdiger Hardeland

  905
  Citations

• Functional roles of melatonin in plants, and perspectives in nutritional and agricultural science

  Dun Xian Tan;Rudiger Hardeland;Lucien C. Manchester;Ahmet Korkmaz

  709
  Citations

• Melatonin: a hormone, a tissue factor, an autocoid, a paracoid, and an antioxidant vitamin

  Dun Xian Tan;Lucien C. Manchester;Rüdiger Hardeland;Silvia Lopez-Burillo

  685
  Citations

• The significance of the metabolism of the neurohormone melatonin: Antioxidative protection and formation of bioactive substances

  R. Hardeland;R.J. Reiter;B. Poeggeler;D.-X. Tan

  599
  Citations

• Melatonin, the circadian multioscillator system and health: the need for detailed analyses of peripheral melatonin signaling.

  Rüdiger Hardeland;Juan Antonio Madrid;Dun Xian Tan;Russel J. Reiter

  526
  Citations

• Non-vertebrate melatonin

  Rüdiger Hardeland;Burkhard Poeggeler;Burkhard Poeggeler

  524
  Citations

• Melatonin and inflammation—Story of a double‐edged blade

  Rüdiger Hardeland

  478
  Citations

• Circadian rhythms, oxidative stress, and antioxidative defense mechanisms.

  Rüdiger Hardeland;Ana Coto-Montes;Burkhard Poeggeler

  443
  Citations

• The changing biological roles of melatonin during evolution: From an antioxidant to signals of darkness, sexual selection and fitness

  Dun Xian Tan;Rüdiger Hardeland;Lucien C. Manchester;Sergio D. Paredes

  432
  Citations

• Anti-inflammatory actions of melatonin and its metabolites, N1-acetyl-N2-formyl-5-methoxykynuramine (AFMK) and N1-acetyl-5-methoxykynuramine (AMK), in macrophages.

  Juan C. Mayo;Rosa M. Sainz;Dun Xian Tan;Rüdiger Hardeland

  408
  Citations

• Melatonin antioxidative defense: therapeutical implications for aging and neurodegenerative processes.

  Seithikurippu R. Pandi-Perumal;Seithikurippu R. Pandi-Perumal;Ahmed S. BaHammam;Gregory M. Brown;Gregory M. Brown;D. Warren Spence

  406
  Citations

• Melatonin

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  376
  Citations

• On the primary functions of melatonin in evolution: Mediation of photoperiodic signals in a unicell, photooxidation, and scavenging of free radicals*

  Ruediger Hardeland;Ivonne Balzer;Burkhard Poeggeler;Birgit Fuhrberg

  369
  Citations

• Melatonin, a potent agent in antioxidative defense: Actions as a natural food constituent, gastrointestinal factor, drug and prodrug

  Rüdiger Hardeland;SR Pandi-Perumal

  350
  Citations

• Aging, Melatonin, and the Pro- and Anti-Inflammatory Networks.

  Rüdiger Hardeland

  350
  Citations

• Melatonin and the theories of aging: a critical appraisal of melatonin's role in antiaging mechanisms

  Rüdiger Hardeland

  349
  Citations

• Reduced oxidative damage in ALS by high-dose enteral melatonin treatment.

  Jochen H. Weishaupt;Claudia Bartels;Esther Pölking;Jeannine Dietrich

  343
  Citations

• On the significance of an alternate pathway of melatonin synthesis via 5-methoxytryptamine: comparisons across species

  Dun Xian Tan;Rüdiger Hardeland;Kyoungwhan Back;Lucien C. Manchester

  330
  Citations