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Chemistry

D-Index
45
Citations
6939
World Ranking
16504
National Ranking
4103

Overview

Peter W. Villalta is affiliated with the University of Minnesota in the United States. Their research output spans the fields of biochemistry, genetics, molecular biology, and medicine, with specific focus in molecular biology, spectroscopy, cancer research, pharmacology, and oncology.

The scientist's work is documented in various peer-reviewed journals and publication venues. Frequent venues include Chemical Research in Toxicology, bioRxiv (Cold Spring Harbor Laboratory), Cell, Analytical Chemistry, and Science Advances.

Key areas of study and main topics covered in Peter W. Villalta's research include:

  • Metabolomics and Mass Spectrometry Studies
  • DNA Repair Mechanisms
  • Carcinogens and Genotoxicity Assessment
  • Mass Spectrometry Techniques and Applications
  • RNA modifications and cancer
  • Analytical Chemistry and Chromatography
  • Nephrotoxicity and Medicinal Plants

Major recent papers that feature their research contributions are:

  • "Small RNAs are modified with N-glycans and displayed on the surface of living cells" (2021), published in Cell
  • "Extracellular matrix stiffness determines DNA repair efficiency and cellular sensitivity to genotoxic agents" (2020), published in Science Advances
  • "A small molecule inhibitor prevents gut bacterial genotoxin production" (2022), published in Nature Chemical Biology
  • "Biosynthesis, Mechanism of Action, and Inhibition of the Enterotoxin Tilimycin Produced by the Opportunistic Pathogen Klebsiella oxytoca" (2020), published in ACS Infectious Diseases
  • "Identification of New Markers of Alcohol-Derived DNA Damage in Humans" (2021), published in Biomolecules

Frequent co-authors with whom Peter W. Villalta has collaborated extensively include Silvia Balbo, Robert J. Turesky, Foster C. Jacobs, Alessia Stornetta, and Scott J. Walmsley. These collaborations have contributed to a breadth of research outputs across several complex topics within molecular biology and toxicology.

Best Publications

  • The human gut bacterial genotoxin colibactin alkylates DNA

    Matthew R. Wilson;Yindi Jiang;Peter W. Villalta;Alessia Stornetta

  • Small RNAs are modified with N-glycans and displayed on the surface of living cells.

    Ryan A Flynn;Kayvon Pedram;Stacy A Malaker;Pedro J Batista

  • Identification of DNA Adducts of Acetaldehyde

    Mingyao Wang;Edward J. McIntee;Guang Cheng;Yongli Shi

  • 2'-Hydroxylation of nicotine by cytochrome P450 2A6 and human liver microsomes: formation of a lung carcinogen precursor.

    Stephen S. Hecht;J. Bradley Hochalter;Peter W. Villalta;Sharon E. Murphy

  • Reactions of formaldehyde plus acetaldehyde with deoxyguanosine and DNA: formation of cyclic deoxyguanosine adducts and formaldehyde cross-links.

    Guang Cheng;Yongli Shi;Shana J Sturla;John R Jalas

  • DNA Adductomics

    Unknown

  • Detection and quantitation of acrolein-derived 1,N2-propanodeoxyguanosine adducts in human lung by liquid chromatography-electrospray ionization-tandem mass spectrometry.

    Siyi Zhang;Peter W. Villalta;Mingyao Wang;Stephen S. Hecht

  • Mass Spectrometry of Structurally Modified DNA

    Natalia Tretyakova;Peter W. Villalta;Srikanth Kotapati

  • Identification of an acetaldehyde adduct in human liver DNA and quantitation as N2-ethyldeoxyguanosine.

    Mingyao Wang;Nanxiong Yu;Li Chen;Peter W. Villalta

  • Identification of Adducts Formed by Pyridyloxobutylation of Deoxyguanosine and DNA by 4-(Acetoxymethylnitrosamino)-1-(3-pyridyl)-1-butanone, a Chemically Activated Form of Tobacco Specific Carcinogens

    Mingyao Wang;Guang Cheng;Shana J. Sturla;Yongli Shi

  • Quantitation of pyridyloxobutyl DNA adducts of tobacco-specific nitrosamines in rat tissue DNA by high-performance liquid chromatography-electrospray ionization-tandem mass spectrometry.

    Yanbin Lao;Peter W. Villalta;Shana J. Sturla;Mingyao Wang

  • Formation and Accumulation of Pyridyloxobutyl DNA Adducts in F344 Rats Chronically Treated With 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone and Enantiomers of Its Metabolite, 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol

    Yanbin Lao;Nanxiong Yu;Fekadu Kassie;Peter W. Villalta

  • Analysis of crotonaldehyde- and acetaldehyde-derived 1,n(2)-propanodeoxyguanosine adducts in DNA from human tissues using liquid chromatography electrospray ionization tandem mass spectrometry.

    Siyi Zhang;Peter W. Villalta;Mingyao Wang;Stephen S. Hecht

  • Analysis of 23 Polycyclic Aromatic Hydrocarbons in Smokeless Tobacco by Gas Chromatography−Mass Spectrometry

    Irina Stepanov;Peter W Villalta;Aleksandar Knezevich;Joni Jensen

  • Reactions of O(3P) with alkyl iodides: Rate coefficients and reaction products

    Mary K. Gilles;Andrew A. Turnipseed;Ranajit K. Talukdar;Yinon Rudich

  • Analysis of Phenanthrene and Benzo[a]pyrene Tetraol Enantiomers in Human Urine: Relevance to the Bay Region Diol Epoxide Hypothesis of Benzo[a]pyrene Carcinogenesis and to Biomarker Studies

    Stephen S. Hecht;Steven G. Carmella;Peter W. Villalta;J. Bradley Hochalter

  • A study of FeCO- and the 3Σ- and 5Σ- states of FeCO by negative ion photoelectron spectroscopy

    Peter W. Villalta;Doreen G. Leopold

  • Quantitation of an Acetaldehyde Adduct in Human Leukocyte DNA and the Effect of Smoking Cessation

    Li Chen;Mingyao Wang;Peter W Villalta;Xianghua Luo

  • Identification of O2-substituted pyrimidine adducts formed in reactions of 4-(acetoxymethylnitrosamino)- 1-(3-pyridyl)-1-butanone and 4-(acetoxymethylnitros- amino)-1-(3-pyridyl)-1-butanol with DNA.

    Stephen S Hecht;Peter W Villalta;Shana J Sturla;Guang Cheng

  • Application of a High-Resolution Mass-Spectrometry-Based DNA Adductomics Approach for Identification of DNA Adducts in Complex Mixtures

    Silvia Balbo;Stephen S. Hecht;Pramod Upadhyaya;Peter W. Villalta

  • Mass spectrometric analysis of relative levels of pyridyloxobutylation adducts formed in the reaction of DNA with a chemically activated form of the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone.

    Shana J. Sturla;Jana Scott;Yanbin Lao;Stephen S. Hecht

Frequent Co-Authors

Stephen S. Hecht
Stephen S. Hecht University of Minnesota
Robert J. Turesky
Robert J. Turesky University of Minnesota
Dorothy K. Hatsukami
Dorothy K. Hatsukami University of Minnesota
Carleton J. Howard
Carleton J. Howard National Oceanic and Atmospheric Administration
Wendy S. Garrett
Wendy S. Garrett Harvard University
David R. Hanson
David R. Hanson Augsburg College
Ranajit K. Talukdar
Ranajit K. Talukdar University of Colorado Boulder
Mary K. Gilles
Mary K. Gilles Lawrence Berkeley National Laboratory
James A. Swenberg
James A. Swenberg University of North Carolina at Chapel Hill
Edward J. Dunlea
Edward J. Dunlea University of Colorado Boulder

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