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Biology and Biochemistry

D-Index
44
Citations
8458
World Ranking
19258
National Ranking
1388

Overview

Masaaki Wachi is affiliated with the Tokyo Institute of Technology in Japan. Their research primarily focuses on the fields of Biochemistry, Genetics, and Molecular Biology, with published work spanning related subfields such as Molecular Biology, Genetics, Endocrinology, Nutrition and Dietetics, and Organic Chemistry.

The scientist's main topics of investigation include:

  • Bacterial Genetics and Biotechnology
  • Microbial Metabolic Engineering and Bioproduction
  • Porphyrin Metabolism and Disorders
  • Biochemical and Molecular Research
  • RNA and Protein Synthesis Mechanisms
  • Genomics and Phylogenetic Studies
  • Escherichia coli Research Studies

Masaaki Wachi's recent publications reflect a focus on bacterial and molecular biology topics. Notable papers include:

  • "Mining RNA-seq data reveals the massive regulon of GcvB small RNA and its physiological significance in maintaining amino acid homeostasis in Escherichia coli", 2021, Molecular Microbiology
  • "RNase E-dependent degradation of tnaA mRNA encoding tryptophanase is prerequisite for the induction of acid resistance in Escherichia coli", 2020, Scientific Reports
  • "A Secondary Metabolic Enzyme Functioned as an Evolutionary Seed of a Primary Metabolic Enzyme", 2022, Molecular Biology and Evolution
  • "Biosynthetic Pathways of Alaremycin and Its Derivative: Inhibitors of Porphobilinogen Synthase in Porphyrin Biosynthesis from Streptomyces sp. A012304", 2025, ACS Bio & Med Chem Au
  • "Requirement of the LtsA Protein for Formation of the Mycolic Acid-Containing Layer on the Cell Surface of Corynebacterium glutamicum", 2021, Microorganisms

They have published frequently in several scientific venues: Molecular Microbiology, Scientific Reports, Molecular Biology and Evolution, ACS Bio & Med Chem Au, and Microorganisms.

Masaaki Wachi has collaborated regularly with a number of coauthors. Frequent collaborators include Noritaka Iwai, Takeshi Kanda, Jun Kawaguchi, Takashi Hirasawa, and Masatoshi Miyakoshi.

Best Publications

  • MreB Actin-Mediated Segregation of a Specific Region of a Bacterial Chromosome

    Zemer Gitai;Natalie Anne Dye;Ann Reisenauer;Masaaki Wachi

  • Molecular cloning of the gene of a penicillin-binding protein supposed to cause high resistance to beta-lactam antibiotics in Staphylococcus aureus.

    M. Matsuhashi;Min Dong Song;F. Ishino;M. Wachi

  • Evolution of an inducible penicillin-target protein in methicillin-resistant Staphylococcus aureus by gene fusion.

    Min Dong Song;Masaaki Wachi;Masaki Doi;Fumitoshi Ishino

  • Synthesis and Antibacterial Activity of a Novel Series of Potent DNA Gyrase Inhibitors. Pyrazole Derivatives

    Akihiko Tanitame;Yoshihiro Oyamada;Keiko Ofuji;Mika Fujimoto

  • Mutant isolation and molecular cloning of mre genes, which determine cell shape, sensitivity to mecillinam, and amount of penicillin-binding proteins in Escherichia coli.

    M. Wachi;M. Doi;S. Tamaki;Wan Park

  • Generation of hydrogen peroxide primarily contributes to the induction of Fe(II)-dependent apoptosis in Jurkat cells by (−)-epigallocatechin gallate

    Hiroshi Nakagawa;Keiji Hasumi;Je-Tae Woo;Kazuo Nagai

  • Mutations of the Corynebacterium glutamicum NCgl1221 gene, encoding a mechanosensitive channel homolog, induce L-glutamic acid production.

    Jun Nakamura;Seiko Hirano;Hisao Ito;Masaaki Wachi

  • Novel S-Benzylisothiourea Compound That Induces Spherical Cells in Escherichia coli Probably by Acting on a Rod-shape-determining Protein(s) Other Than Penicillin-binding Protein 2

    Noritaka Iwai;Kazuo Nagai;Masaaki Wachi

  • Determinations of the DNA sequence of the mreB gene and of the gene products of the mre region that function in formation of the rod shape of Escherichia coli cells.

    M Doi;M Wachi;F Ishino;S Tomioka

  • Fenton Reaction Is Primarily Involved in a Mechanism of (−)-Epigallocatechin-3-gallate to Induce Osteoclastic Cell Death ☆

    Hiroshi Nakagawa;Masaaki Wachi;Je-Tae Woo;Masanori Kato

  • Structural similarity among Escherichia coli FtsW and RodA proteins and Bacillus subtilis SpoVE protein, which function in cell division, cell elongation, and spore formation, respectively.

    M Ikeda;T Sato;M Wachi;H K Jung

  • New mre genes mreC and mreD, responsible for formation of the rod shape of Escherichia coli cells.

    M Wachi;M Doi;Y Okada;M Matsuhashi

  • Negative control of cell division by mreB, a gene that functions in determining the rod shape of Escherichia coli cells.

    M Wachi;M Matsuhashi

  • Synthesis and antibacterial activity of novel and potent DNA gyrase inhibitors with azole ring.

    Akihiko Tanitame;Yoshihiro Oyamada;Keiko Ofuji;Mika Fujimoto

  • The Escherichia coli mraY gene encoding UDP-N-acetylmuramoyl-pentapeptide: undecaprenyl-phosphate phospho-N-acetylmuramoyl-pentapeptide transferase.

    M Ikeda;M Wachi;H K Jung;F Ishino

  • Actin homolog MreB and RNA polymerase interact and are both required for chromosome segregation in Escherichia coli

    Thomas Kruse;Blagoy Blagoev;Anders Løbner-Olesen;Masaaki Wachi

  • Escherichia coli cafA gene encodes a novel RNase, designated as RNase G, involved in processing of the 5' end of 16S rRNA.

    Masaaki Wachi;Genryou Umitsuki;Miwa Shimizu;Ayako Takada

  • Synthesis and antibacterial activity of a novel series of DNA gyrase inhibitors: 5-[(E)-2-arylvinyl]pyrazoles.

    Akihiko Tanitame;Yoshihiro Oyamada;Keiko Ofuji;Hideo Terauchi

  • Effects of high hydrostatic pressure on bacterial cytoskeleton FtsZ polymers in vivo and in vitro.

    Akihiro Ishii;Akihiro Ishii;Takako Sato;Masaaki Wachi;Kazuo Nagai

  • Machinery for cell growth and division: Penicillin-binding proteins and other proteins

    M. Matsuhashi;M. Wachi;F. Ishino

Frequent Co-Authors

Kazuo Nagai
Kazuo Nagai Chubu University
Kenji Suzuki
Kenji Suzuki Juntendo University
Dieter Jahn
Dieter Jahn Technische Universität Braunschweig
Motoyuki Sugai
Motoyuki Sugai National Institute of Infectious Diseases
Hiroshi Shimizu
Hiroshi Shimizu Osaka University
Min Yao
Min Yao Hokkaido University
Dirk W. Heinz
Dirk W. Heinz University of Freiburg
Yoshimi Okada
Yoshimi Okada University of Tokyo
Anders Løbner-Olesen
Anders Løbner-Olesen University of Copenhagen
Kenn Gerdes
Kenn Gerdes University of Copenhagen

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