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Genetics

D-Index
58
Citations
25544
World Ranking
3288
National Ranking
1432

Overview

Joshua D. Smith is affiliated with the University of Washington in the United States. Their research spans several fields within biochemistry, genetics, molecular biology, and medicine, with a focus on pharmacology, plant science, molecular biology, statistics and probability, and oncology.

Their work is primarily concentrated on topics such as pharmacogenetics and drug metabolism, plant-microbe interactions and immunity, CRISPR and genetic engineering, statistical methods in clinical trials, drug transport and resistance mechanisms, microbial natural products and biosynthesis, and fungal biology and applications.

Joshua D. Smith has published research in multiple venues. Frequent publication venues include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Journal of Molecular Diagnostics
  • Communications Biology

Their recent papers cover various aspects of genetics, pharmacogenomics, and fungal biology. Notable publications include:

  • "CYP2C8, CYP2C9, and CYP2C19 Characterization Using Next-Generation Sequencing and Haplotype Analysis" (2022, Journal of Molecular Diagnostics)
  • "Adaptive laboratory evolution in S. cerevisiae highlights role of transcription factors in fungal xenobiotic resistance" (2022, Communications Biology)
  • "Frequency of pharmacogenomic variation and medication exposures among All of Us Participants" (2024, bioRxiv (Cold Spring Harbor Laboratory))
  • "The Platinum Pedigree: A long-read benchmark for genetic variants" (2024, bioRxiv (Cold Spring Harbor Laboratory))
  • "Defining the Yeast Resistome through in vitro Evolution and Whole Genome Sequencing" (2021, bioRxiv (Cold Spring Harbor Laboratory))

Frequent co-authors collaborating with Joshua D. Smith include:

  • Sean McGee
  • Aparna Radhakrishnan
  • Sabine Ottilie
  • Madeline R. Luth
  • Erich Hellemann

The scientist's research encompasses advanced techniques in next-generation sequencing, long-read genetic variant benchmarking, and experimental evolution focused on fungal resistance. Their studies integrate molecular diagnostics with pharmacogenomic data to understand variation across populations and mechanisms of drug metabolism.

Joshua D. Smith's work contributes to the integration of molecular biology with clinical and pharmacological applications, highlighting genetic factors that affect drug response and resistance. The combination of research topics and diverse publication outlets reflects a multidisciplinary approach to understanding complex biological interactions at molecular and cellular levels.

Best Publications

  • Biological, clinical and population relevance of 95 loci for blood lipids

    Tanya M. Teslovich;Kiran Musunuru;Albert V. Smith;Andrew C. Edmondson

  • The contribution of de novo coding mutations to autism spectrum disorder

    Ivan Iossifov;Brian J. O'Roak;Stephan J. Sanders;Stephan J. Sanders;Michael Ronemus

  • Sporadic autism exomes reveal a highly interconnected protein network of de novo mutations

    Brian J. O’Roak;Laura Vives;Santhosh Girirajan;Emre Karakoc

  • Exome sequencing identifies MLL2 mutations as a cause of Kabuki syndrome

    Sarah B. Ng;Abigail W. Bigham;Kati J. Buckingham;Mark C. Hannibal;Mark C. Hannibal

  • Mapping and sequencing of structural variation from eight human genomes

    Jeffrey M. Kidd;Gregory M. Cooper;William F. Donahue;Hillary S. Hayden

  • The genetic architecture of type 2 diabetes

    Christian Fuchsberger;Christian Fuchsberger;Jason A. Flannick;Jason A. Flannick;Tanya M. Teslovich;Anubha Mahajan

  • The Genetic Basis of Mendelian Phenotypes: Discoveries, Challenges, and Opportunities

    Jessica X. Chong;Kati J. Buckingham;Shalini N. Jhangiani;Corinne Boehm

  • Novel Loci for Adiponectin Levels and Their Influence on Type 2 Diabetes and Metabolic Traits: A Multi-Ethnic Meta-Analysis of 45,891 Individuals

    Z Dastani;Hivert M-F.;Hivert M-F.;N Timpson;Perry Jrb.;Perry Jrb.

  • A genome-wide scan for common genetic variants with a large influence on warfarin maintenance dose

    Gregory M. Cooper;Julie A. Johnson;Taimour Y. Langaee;Hua Feng

  • Discovery of common and rare genetic risk variants for colorectal cancer

    Jeroen R. Huyghe;Stephanie A. Bien;Tabitha A. Harrison;Hyun Min Kang

  • A Multivariate Genome-Wide Association Analysis of 10 LDL Subfractions, and Their Response to Statin Treatment, in 1868 Caucasians

    Heejung Shim;Daniel I. Chasman;Joshua D. Smith;Samia Mora

  • Additional SNPs and linkage-disequilibrium analyses are necessary for whole-genome association studies in humans

    Christopher S. Carlson;Michael A. Eberle;Mark J. Rieder;Joshua D. Smith

  • De novo rates and selection of large copy number variation

    Andy Itsara;Hao Wu;Joshua D. Smith;Deborah A. Nickerson

  • Genome Sequencing of Autism-Affected Families Reveals Disruption of Putative Noncoding Regulatory DNA

    Tychele N. Turner;Fereydoun Hormozdiari;Michael H. Duyzend;Sarah A. McClymont

  • Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins

    Iris Postmus;Stella Trompet;Harshal A. Deshmukh;Michael R. Barnes

  • Mutations in TJP2 cause progressive cholestatic liver disease

    Melissa Sambrotta;Sandra Strautnieks;Efterpi Papouli;Peter Rushton

  • Genome-Wide Association of Lipid-Lowering Response to Statins in Combined Study Populations

    Mathew J. Barber;Lara M. Mangravite;Craig L. Hyde;Daniel I. Chasman

  • Identification, Replication, and Functional Fine-Mapping of Expression Quantitative Trait Loci in Primary Human Liver Tissue

    Federico Innocenti;Gregory M. Cooper;Ian B. Stanaway;Eric R. Gamazon

  • A statin-dependent QTL for GATM expression is associated with statin-induced myopathy

    Lara M. Mangravite;Barbara E. Engelhardt;Barbara E. Engelhardt;Marisa W. Medina;Joshua D. Smith

  • Whole-Exome Sequencing Identifies Rare and Low-Frequency Coding Variants Associated with LDL Cholesterol

    Leslie A Lange;Youna Hu;He Zhang;Chenyi Xue

Frequent Co-Authors

Deborah A. Nickerson
Deborah A. Nickerson University of Washington
Michael J. Bamshad
Michael J. Bamshad University of Washington
Jay Shendure
Jay Shendure University of Washington
Mark J. Rieder
Mark J. Rieder University of Washington
David Altshuler
David Altshuler Harvard University
Suzanne M. Leal
Suzanne M. Leal Columbia University Medical Center
Gonçalo R. Abecasis
Gonçalo R. Abecasis University of Michigan–Ann Arbor
Jerome I. Rotter
Jerome I. Rotter UCLA Medical Center
Shaun Purcell
Shaun Purcell Harvard Medical School
Eric Boerwinkle
Eric Boerwinkle The University of Texas Health Science Center at Houston

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