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Chemistry

D-Index
47
Citations
8171
World Ranking
15625
National Ranking
1143

Overview

Heiko Heerklotz is affiliated with the University of Freiburg in Germany and specializes in biochemical and molecular biology research. Their work spans several interconnected areas, focusing primarily on lipid membrane structure and behavior, with numerous contributions to the understanding of surfactants, antimicrobial peptides, and nanoparticle-based drug delivery systems.

The scientist's research portfolio includes detailed studies on lipid membranes and their interactions, often addressing how such interactions influence drug delivery and membrane integrity. Heerklotz has published extensively on topics such as RNA interference and gene delivery, protein interaction studies, as well as methodological advancements like field-flow fractionation techniques.

Frequent venues for Heerklotz's publications demonstrate a strong presence in biophysical and pharmaceutical sciences. Notably, they have contributed multiple papers to the Biophysical Journal, Molecular Pharmaceutics, and Faraday Discussions. Other publication outlets include Pharmaceutics and The Journal of Physical Chemistry B.

Recent publications by Heerklotz illustrate a focus on the molecular and biophysical properties of membranes and membrane-active substances. These include:

  • Complex Micellization Behavior of the Polysorbates Tween 20 and Tween 80, 2021, Molecular Pharmaceutics
  • Lipid Scrambling Induced by Membrane-Active Substances, 2020, Biophysical Journal
  • Determining critical parameters that influence in vitro performance characteristics of a thermosensitive liposome formulation of vinorelbine, 2020, Journal of Controlled Release
  • A Guide to Your Desired Lipid-Asymmetric Vesicles, 2023, Membranes
  • The Optimal Lipid Chain Length of a Membrane-Permeabilizing Lipopeptide Results From the Balance of Membrane Partitioning and Local Damage, 2021, Frontiers in Microbiology

Heerklotz frequently collaborates with various researchers within their domain, including Iulia Carabadjac, Jessica Steigenberger, Georg Pabst, José C. Martins, and Johannes Schnur, with multiple joint publications reflecting ongoing collaborative efforts.

The main fields of study associated with Heerklotz cover biochemistry, genetics, and molecular biology, with significant subfields including molecular biology, biomaterials, microbiology, organic chemistry, and biomedical engineering. The breadth of these fields indicates a multidisciplinary approach that integrates chemistry and biology with engineering principles.

The principal research topics Heerklotz engages with include:

  • Lipid Membrane Structure and Behavior
  • Nanoparticle-Based Drug Delivery
  • Surfactants and Colloidal Systems
  • Antimicrobial Peptides and Activities
  • RNA Interference and Gene Delivery
  • Field-Flow Fractionation Techniques
  • Protein Interaction Studies and Fluorescence Analysis

Best Publications

  • Triton Promotes Domain Formation in Lipid Raft Mixtures

    H. Heerklotz

  • Detergent-resistant membranes should not be identified with membrane rafts

    Dov Lichtenberg;Félix M. Goñi;Heiko Heerklotz

  • Interactions of surfactants with lipid membranes.

    Heiko Heerklotz

  • Titration calorimetry of surfactant-membrane partitioning and membrane solubilization.

    H Heerklotz;J Seelig

  • Detergent-like action of the antibiotic peptide surfactin on lipid membranes.

    Heiko Heerklotz;Joachim Seelig

  • Structure of BeF3−-Modified Response Regulator PleD: Implications for Diguanylate Cyclase Activation, Catalysis, and Feedback Inhibition

    Paul Wassmann;Carmen Chan;Ralf Paul;Andreas Beck

  • Correlation of membrane/water partition coefficients of detergents with the critical micelle concentration.

    H. Heerklotz;J. Seelig

  • Leakage and lysis of lipid membranes induced by the lipopeptide surfactin.

    Heiko Heerklotz;Joachim Seelig

  • Activation of the diguanylate cyclase PleD by phosphorylation-mediated dimerization

    Ralf Paul;Sören Abel;Paul Wassmann;Andreas Beck

  • The sensitivity of lipid domains to small perturbations demonstrated by the effect of Triton.

    Heiko Heerklotz;Halina Szadkowska;Thomas Anderson;Joachim Seelig

  • Classifying Surfactants with Respect to Their Effect on Lipid Membrane Order

    Mozhgan Nazari;Mustafa Kurdi;Heiko Heerklotz

  • All-or-none membrane permeabilization by fengycin-type lipopeptides from Bacillus subtilis QST713.

    Hiren Patel;Clemens Tscheka;Katarina Edwards;Göran Karlsson

  • The Enthalpy of Acyl Chain Packing and the Apparent Water-Accessible Apolar Surface Area of Phospholipids

    Heiko Heerklotz;Richard M. Epand

  • Molecular determinants for the recruitment of the ubiquitin-ligase MuRF-1 onto M-line titin

    Michael Mrosek;Dietmar Labeit;Stephanie Witt;Heiko Heerklotz

  • The microcalorimetry of lipid membranes

    Heiko Heerklotz

  • Characterizing Vesicle Leakage By Fluorescence Lifetime Measurements

    Hiren Patel;Clemens Tscheka;Heiko Heerklotz

  • Characterizing vesicle leakage by fluorescence lifetime measurements

    Hiren Patel;Clemens Tscheka;Heiko Heerklotz

  • Interactions of cholesterol with lipid membranes and cyclodextrin characterized by calorimetry.

    Alekos Tsamaloukas;Halina Szadkowska;Peter J. Slotte;Heiko Heerklotz

  • Volumetric characterization of sodium-induced G-quadruplex formation.

    Helen Y. Fan;Yuen Lai Shek;Amir Amiri;David N. Dubins

  • Thermodynamic Characterization of Dilute Aqueous Lipid/Detergent Mixtures of POPC and C12EO8 by Means of Isothermal Titration Calorimetry

    H. Heerklotz;G. Lantzsch;H. Binder;G. Klose

  • Thermodynamic comparison of the interactions of cholesterol with unsaturated phospholipid and sphingomyelins.

    Alekos Tsamaloukas;Halina Szadkowska;Heiko Heerklotz

Frequent Co-Authors

Joachim Seelig
Joachim Seelig University of Basel
Alfred Blume
Alfred Blume Martin Luther University Halle-Wittenberg
Sandro Keller
Sandro Keller University of Graz
John E. Ladbury
John E. Ladbury University of Leeds
William A. Wakeham
William A. Wakeham Imperial College London
Göran Karlsson
Göran Karlsson Uppsala University
Samuel H. Gellman
Samuel H. Gellman University of Wisconsin–Madison
Stephen E. Stein
Stephen E. Stein National Institute of Standards and Technology
Tigran V. Chalikian
Tigran V. Chalikian University of Toronto
Urs Jenal
Urs Jenal University of Basel

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