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Chemistry

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65
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13677
World Ranking
7743
National Ranking
2262

Biology and Biochemistry

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67
Citations
14584
World Ranking
8290
National Ranking
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Overview

Douglas A. Gage is affiliated with Michigan State University in the United States. Their research primarily focuses on the field of Medicine, with significant contributions to Dermatology, as well as related subfields including Pathology and Forensic Medicine, Rheumatology, Oncology, and Immunology. The scientist's work intersects multiple areas of study and addresses complex mechanisms related to skin diseases and immune responses.

The main topics of their research include:

  • Dermatology and Skin Diseases
  • Medicine and Dermatology Studies History
  • Autoimmune Bullous Skin Diseases
  • Urticaria and Related Conditions
  • Psoriasis: Treatment and Pathogenesis
  • Cancer Immunotherapy and Biomarkers
  • Cytokine Signaling Pathways and Interactions

Their publications appear most frequently in the Journal of Investigative Dermatology, with a total of six papers. These recent works, all published in 2025, investigate various biological and immunological aspects of prurigo nodularis and related dermatological conditions. Notable papers include:

  • "0910 High-dimensional cutaneous and systemic immunophenotyping of prurigo nodularis reveals dysregulation of IL-6 family cytokine signaling" (2025, Journal of Investigative Dermatology)
  • "0164 Spatial transcriptomic analysis identifies markers of neuroinflammation and keratinocyte hyperproliferation in prurigo nodularis" (2025, Journal of Investigative Dermatology)
  • "0165 Transcriptomic analysis reveals unique neuroimmune, fibrotic, and extracellular matrix remodeling mechanisms in prurigo nodularis compared to atopic dermatitis and psoriasis" (2025, Journal of Investigative Dermatology)
  • "0126 Spatial and single cell proteomic analysis reveal alterations in type2 inflammation in prurigo nodularis and atopic dermatitis" (2025, Journal of Investigative Dermatology)
  • "0966 Peripheral blood high-dimension flow cytometry of chronic pruritus of unknown origin reveals il-31 and oncostatin m+ producing circulating blood cd4+ tcells" (2025, Journal of Investigative Dermatology)

Frequent coauthors contributing to these studies include:

  • Kalyani Vats
  • S. Shahsavari
  • Yagiz Matthew Akiska
  • Louis J. Born
  • S. Kwatra

The scientist's research engages detailed immunophenotyping, spatial transcriptomics, and proteomic analyses to better understand neuroimmune interactions, fibrotic processes, and inflammatory pathways in skin diseases. The work on cytokine signaling pathways, particularly involving IL-6 family cytokines and IL-31, contributes to elucidating mechanisms of pruritus and inflammatory dermatologic disorders.

Best Publications

  • Specific Oxidative Cleavage of Carotenoids by VP14 of Maize

    Steven H. Schwartz;Bao Cai Tan;Bao Cai Tan;Douglas A. Gage;Douglas A. Gage;Jan A. D. Zeevaart;Jan A. D. Zeevaart

  • Bile Acid Secreted by Male Sea Lamprey That Acts as a Sex Pheromone

    Weiming Li;Alexander P. Scott;Michael J. Siefkes;Honggao Yan

  • Identification of a peptide toxin from Grammostola spatulata spider venom that blocks cation-selective stretch-activated channels.

    Thomas M. Suchyna;Janice H. Johnson;Katherine Hamer;Joseph F. Leykam

  • Peptidoglycan composition of a highly methicillin-resistant Staphylococcus aureus strain. The role of penicillin binding protein 2A.

    B. L. M. De Jonge;Yoon-Seok Chang;D. Gage;A. Tomasz

  • Osmoprotective compounds in the plumbaginaceae : a natural experiment in metabolic engineering of stress tolerance

    Andrew D. Hanson;Bala Rathinasabapathi;Jean Rivoal;Michael Burnet

  • THE GA5 LOCUS OF ARABIDOPSIS THALIANA ENCODES A MULTIFUNCTIONAL GIBBERELLIN 20-OXIDASE : MOLECULAR CLONING AND FUNCTIONAL EXPRESSION

    Yun-Ling Xu;Li Li;Keqiang Wu;Anton J. M. Peeters

  • S-Methylmethionine Plays a Major Role in Phloem Sulfur Transport and Is Synthesized by a Novel Type of Methyltransferase

    Fabienne Bourgis;Sanja Roje;Michael L. Nuccio;Donald B. Fisher

  • Proteomic Study of the Arabidopsis thaliana Chloroplastic Envelope Membrane Utilizing Alternatives to Traditional Two-Dimensional Electrophoresis

    John E. Froehlich;Curtis G. Wilkerson;W. Keith Ray;Rosemary S. McAndrew

  • Choline monooxygenase, an unusual iron-sulfur enzyme catalyzing the first step of glycine betaine synthesis in plants: prosthetic group characterization and cDNA cloning.

    Bala Rathinasabapathi;Michael Burnet;Michael Burnet;Brenda L. Russell;Douglas A. Gage

  • Accumulation of a novel glycolipid and a betaine lipid in cells of Rhodobacter sphaeroides grown under phosphate limitation.

    C. Benning;Zhi-Heng Huang;D. A. Gage

  • Phytoalexin Accumulation in Arabidopsis thaliana during the Hypersensitive Reaction to Pseudomonas syringae pv syringae

    Jun Tsuji;Evelyn P. Jackson;Douglas A. Gage;Raymond Hammerschmidt

  • Fatty Acid Substrate Specificities of Human Prostaglandin-endoperoxide H Synthase-1 and −2 FORMATION OF 12-HYDROXY-(9Z,13E/Z,15Z)-OCTADECATRIENOIC ACIDS FROM α-LINOLENIC ACID

    Odette Laneuville;Debra K. Breuer;Naxing Xu;Z.H. Huang

  • Trypanothione overproduction and resistance to antimonials and arsenicals in Leishmania.

    Rita Mukhopadhyay;Saibal Dey;Naxing Xu;Douglas Gage

  • The endogenous choline supply limits glycine betaine synthesis in transgenic tobacco expressing choline monooxygenase

    Michael L. Nuccio;Brenda L. Russell;Kurt D. Nolte;Bala Rathinasabapathi

  • A new route for synthesis of dimethylsulphoniopropionate in marine algae

    Douglas A. Gage;David Rhodes;Kurt D. Nolte;Wayne A. Hicks

  • Recombinant brassinosteroid insensitive 1 receptor-like kinase autophosphorylates on serine and threonine residues and phosphorylates a conserved peptide motif in vitro.

    Man-Ho Oh;William K. Ray;Steven C. Huber;John M. Asara

  • The inhibitor protein of phosphorylated nitrate reductase from spinach (Spinacia oleracea) leaves is a 14-3-3 protein

    Markus Bachmann;Markus Bachmann;Joan L. Huber;Joan L. Huber;Pao Chi Liao;Douglas A. Gage

  • Metabolic engineering of glycine betaine synthesis: plant betaine aldehyde dehydrogenases lacking typical transit peptides are targeted to tobacco chloroplasts where they confer betaine aldehyde resistance

    Bala Rathinasabapathi;Kent F. McCue;Douglas A. Gage;Andrew D. Hanson

  • Hetero-oligomerization-dependent Binding of Pig Oocyte Zona Pellucida Glycoproteins ZPB and ZPC to Boar Sperm Membrane Vesicles

    Edward C. Yurewicz;Anthony G. Sacco;Satish K. Gupta;Naxing Xu

  • Phosphorylation of serine-15 of maize leaf sucrose synthase. Occurrence in vivo and possible regulatory significance.

    S. C. Huber;J. L. Huber;P. C. Liao;D. A. Gage

  • Molecular Cloning and Photoperiod-Regulated Expression of Gibberellin 20-Oxidase from the Long-Day Plant Spinach

    Keqiang Wu;Li Li;Douglas A. Gage;Jan A. D. Zeevaart

Frequent Co-Authors

Andrew D. Hanson
Andrew D. Hanson University of Florida
Jan A. D. Zeevaart
Jan A. D. Zeevaart Michigan State University
Bala Rathinasabapathi
Bala Rathinasabapathi University of Florida
Charles C. Sweeley
Charles C. Sweeley Michigan State University
David Rhodes
David Rhodes Purdue University West Lafayette
Steven C. Huber
Steven C. Huber University of Illinois at Urbana-Champaign
Iracilda Sampaio
Iracilda Sampaio Federal University of Para
Elaine I. Tuomanen
Elaine I. Tuomanen St. Jude Children's Research Hospital
Manuel Talón
Manuel Talón Instituto Valenciano de Investigaciones Agrarias
Morris Goodman
Morris Goodman Wayne State University

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