Member of the Association of American Physicians
His scientific interests lie mostly in Cartilage, Osteoarthritis, Biochemistry, Proteoglycan and Anatomy. The study incorporates disciplines such as Collagen network, Metalloproteinase, Enzyme, Molecular biology and Anterior cruciate ligament in addition to Cartilage. David S. Howell has included themes like Inflammation, Internal medicine, Guanidine and Endocrinology in his Osteoarthritis study.
His Internal medicine research integrates issues from Upper limb and Radiography. His Biochemistry research is multidisciplinary, incorporating elements of Calcification and Calcium. His study in Proteoglycan is interdisciplinary in nature, drawing from both Casein and Collagenase.
His main research concerns Cartilage, Internal medicine, Endocrinology, Osteoarthritis and Proteoglycan. His Cartilage research incorporates elements of Calcification, Pathology, Glycosaminoglycan and Enzyme. The Internal medicine study combines topics in areas such as Alkaline phosphatase, Pyrophosphate and Cardiology.
His Rickets, Vitamin, Hydroxyproline and Metabolism study in the realm of Endocrinology connects with subjects such as Insulin-like growth factor. His Osteoarthritis study combines topics from a wide range of disciplines, such as Inflammation, Physical therapy, Surgery and Bioinformatics. The Proteoglycan study which covers Articular cartilage that intersects with Anterior cruciate ligament.
David S. Howell mainly investigates Cartilage, Internal medicine, Proteoglycan, Endocrinology and Osteoarthritis. To a larger extent, he studies Anatomy with the aim of understanding Cartilage. Internal medicine and Pathology are frequently intertwined in his study.
As a part of the same scientific family, David S. Howell mostly works in the field of Endocrinology, focusing on Metalloproteinase and, on occasion, Matrix Metalloproteinase 3, Western blot and Tissue inhibitor of metalloproteinase. His Osteoarthritis research incorporates themes from Diagnostic marker and Surgery. His work is dedicated to discovering how Biochemistry, Matrix are connected with Matrix metalloproteinase and other disciplines.
The scientist’s investigation covers issues in Cartilage, Proteoglycan, Matrix metalloproteinase, Articular cartilage and Extracellular matrix. His biological study spans a wide range of topics, including Osteoarthritis, Compression and Joint immobilization. His studies in Osteoarthritis integrate themes in fields like Bone matrix and Crystal deposition.
His work focuses on many connections between Proteoglycan and other disciplines, such as Vesicle, that overlap with his field of interest in Matrix and Molecular biology. His study explores the link between Matrix metalloproteinase and topics such as Collagenase that cross with problems in Therapeutic effect, Urology, Surgery and Cartilage metabolism. His Articular cartilage research is multidisciplinary, relying on both Ultimate tensile strength, Isometric exercise, Anterior cruciate ligament, Anatomy and FEMORAL CONDYLE.
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Development of criteria for the classification and reporting of osteoarthritis: Classification of osteoarthritis of the knee
R. Altman;E. Asch;D. Bloch;G. Bole.
Arthritis & Rheumatism (1986)
The American College of Rheumatology criteria for the classification and reporting of osteoarthritis of the hip.
R. Altman;G. Alarcón;D. Appelrouth;D. Bloch.
Arthritis & Rheumatism (1990)
Evidence for metalloproteinase and metalloproteinase inhibitor imbalance in human osteoarthritic cartilage.
David D Dean;J. Martel-Pelletier;J. P. Pelletier;D. S. Howell.
Journal of Clinical Investigation (1989)
Tensile properties of human knee joint cartilage: I. Influence of ionic conditions, weight bearing, and fibrillation on the tensile modulus.
Shaw Akizuki;Van C. Mow;Francisco Müller;Julio C. Pita.
Journal of Orthopaedic Research (1986)
Pathogenesis of osteoarthritis
David S. Howell.
The American Journal of Medicine (1986)
Mechanical Properties of Canine Articular Cartilage Are Significantly Altered Following Transection of the Anterior Cruciate Ligament
L. A. Setton;V. C. Mow;F. J. Müller;J. C. Pita.
Journal of Orthopaedic Research (1994)
Neutral proteases capable of proteoglycan digesting activity in osteoarthritic and normal human articular cartilage
Johanne Martel‐Pelletier;Jean‐Pierre Pelletier;Jean‐Marie Cloutier;David S. Howell.
Arthritis & Rheumatism (1984)
Collagenase and collagenolytic activity in human osteoarthritic cartilage
Jean‐Pierre Pelletier;Johanne Martel‐Pelletier;David S. Howell;Latifa Ghandur‐Mnaymneh.
Arthritis & Rheumatism (1983)
Partition of calcium, phosphate, and protein in the fluid phase aspirated at calcifying sites in epiphyseal cartilage
David S. Howell;Julio C. Pita;Juan F. Marquez;Juan E. Madruga.
Journal of Clinical Investigation (1968)
Metalloproteases of human articular cartilage that digest cartilage proteoglycan at neutral and acid pH.
A I Sapolsky;H Keiser;D S Howell;J F Woessner.
Journal of Clinical Investigation (1976)
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