Arnold Louie

Best Publications

• Treatment of invasive aspergillosis with posaconazole in patients who are refractory to or intolerant of conventional therapy: An externally controlled trial

  Thomas J. Walsh;Issam Raad;Thomas F. Patterson;Pranatharthi Chandrasekar

  874
  Citations

• Pharmacokinetics-Pharmacodynamics of Antimicrobial Therapy: It's Not Just for Mice Anymore

  Paul G. Ambrose;Sujata M. Bhavnani;Christopher M. Rubino;Arnold Louie

  819
  Citations

• Selection of a Moxifloxacin Dose That Suppresses Drug Resistance in Mycobacterium tuberculosis, by Use of an In Vitro Pharmacodynamic Infection Model and Mathematical Modeling

  Tawanda Gumbo;Arnold Louie;Mark R. Deziel;Linda M. Parsons

  449
  Citations

• Concentration-Dependent Mycobacterium tuberculosis Killing and Prevention of Resistance by Rifampin

  Tawanda Gumbo;Arnold Louie;Mark R. Deziel;Weiguo Liu

  425
  Citations

• Application of a mathematical model to prevent in vivo amplification of antibiotic-resistant bacterial populations during therapy

  Nelson Jumbe;Arnold Louie;Robert Leary;Weiguo Liu

  324
  Citations

• Back to the Future: Using Aminoglycosides Again and How to Dose Them Optimally

  George L Drusano;Paul G Ambrose;Sujata M Bhavnani;Joseph S Bertino

  297
  Citations

• Application of a mathematical model to prevent in vivo amplification of antibiotic-resistant bacterial populations during therapy

  Unknown

  234
  Citations

• Pharmacodynamics of Caspofungin in a Murine Model of Systemic Candidiasis: Importance of Persistence of Caspofungin in Tissues to Understanding Drug Activity

  Arnold Louie;Mark Deziel;Weiguo Liu;Michael F. Drusano

  226
  Citations

• Isoniazid bactericidal activity and resistance emergence: integrating pharmacodynamics and pharmacogenomics to predict efficacy in different ethnic populations.

  Tawanda Gumbo;Arnold Louie;Weiguo Liu;David Brown

  195
  Citations

• Pharmacodynamics of Daptomycin in a Murine Thigh Model of Staphylococcus aureus Infection

  Unknown

  185
  Citations

• The Relationship between Quinolone Exposures and Resistance Amplification Is Characterized by an Inverted U: a New Paradigm for Optimizing Pharmacodynamics To Counterselect Resistance

  Vincent H. Tam;Arnold Louie;Mark R. Deziel;Weiguo Liu

  181
  Citations

• Generating Robust and Informative Nonclinical In Vitro and In Vivo Bacterial Infection Model Efficacy Data To Support Translation to Humans.

  Jürgen B. Bulitta;William W. Hope;Ann E. Eakin;Tina Guina

  165
  Citations

• Bacterial-population responses to drug-selective pressure: examination of garenoxacin's effect on Pseudomonas aeruginosa.

  Vincent H. Tam;Arnold Louie;Mark R. Deziel;Weiguo Liu

  159
  Citations

• Pharmacodynamics of Fluconazole in a Murine Model of Systemic Candidiasis

  Unknown

  155
  Citations

• Isoniazid's Bactericidal Activity Ceases because of the Emergence of Resistance, Not Depletion of Mycobacterium tuberculosis in the Log Phase of Growth

  Tawanda Gumbo;Arnold Louie;Weiguo Liu;Paul G. Ambrose

  139
  Citations

• Once-Weekly Micafungin Therapy Is as Effective as Daily Therapy for Disseminated Candidiasis in Mice with Persistent Neutropenia

  Tawanda Gumbo;George L. Drusano;Weiguo Liu;Robert W. Kulawy

  134
  Citations

• Impact of Drug-Exposure Intensity and Duration of Therapy on the Emergence of Staphylococcus aureus Resistance to a Quinolone Antimicrobial

  V. H. Tam;A. Louie;T. R. Fritsche;M. Deziel

  128
  Citations

• Optimization of Aminoglycoside Therapy

  G. L. Drusano;Arnold Louie

  123
  Citations

• Tumor necrosis factor alpha has a protective role in a murine model of systemic candidiasis

  Unknown

  121
  Citations

• Impact of Granulocytes on the Antimicrobial Effect of Tedizolid in a Mouse Thigh Infection Model

  G. L. Drusano;Weiguo Liu;Robert Kulawy;Arnold Louie

  116
  Citations