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Xenobiotica
H-index 11

Xenobiotica

0049-8254

Published by: Taylor & Francis

https://www.tandfonline.com/toc/ixen20/current

Ranking & Metrics

Discipline name Position Best Scientists Publications D-Index
Chemistry 794 24 42 8

Additional Metrics

Number of Best Scientists*: 80
Documents by Best Scientists*: 98
Top 100 Ranked Scientists*: 2
SCIMAGO H-index: 91
SCIMAGO SJR: 0.348
Impact Factor: 1.2

Overview

Top Research Topics at Xenobiotica?

The journal generally zeroes in on subjects such as Pharmacology, Metabolism, Biochemistry, Metabolite and Pharmacokinetics. Pharmacology research presented in it encompasses a variety of subjects, including CYP3A4 and In vivo. The studies in Metabolism featured incorporate elements of Urine, Stereochemistry and Hydroxylation.

The journal explores research in Excretion and overlapping concepts in Absorption (skin) to expand the discourse in Urine. Biochemistry studies presented in the journal focus on topics such as Microsome, Enzyme, In vitro, Glutathione and Drug metabolism. While the primary focus in it is Microsome, it also dissects topics surrounding Cytochrome P450 and Isozyme as a whole.

The journal addresses concerns in Metabolite which are intertwined with other disciplines, such as Chromatography, Biotransformation and Metabolic pathway. The research on Pharmacokinetics discussed in the journal draws on the closely related field of Distribution (pharmacology). The works on Internal medicine deal in particular with Toxicity.

  • Pharmacology (36.93%)
  • Metabolism (36.41%)
  • Biochemistry (33.20%)

What are the most cited papers published in the journal?

  • 'METABONOMICS': UNDERSTANDING THE METABOLIC RESPONSES OF LIVING SYSTEMS TO PATHOPHYSIOLOGICAL STIMULI VIA MULTIVARIATE STATISTICAL ANALYSIS OF BIOLOGICAL NMR SPECTROSCOPIC DATA (3019 citations)
  • Mammalian epoxide hydrases: inducible enzymes catalysing the inactivation of carcinogenic and cytotoxic metabolites derived from aromatic and olefinic compounds. (770 citations)
  • Structure, function and regulation of P-glycoprotein and its clinical relevance in drug disposition (445 citations)

Research areas of the most cited articles at Xenobiotica:

The journal publications tackle a plethora of topics, such as Biochemistry, Pharmacology, Metabolism, Microsome and Metabolite. While the most cited papers focused on Pharmacology, they were also able to explore topics like CYP3A4 and In vivo. The journal papers focus on Metabolism but the discussions also offer insight into other areas such as Urine, Glutathione and Biotransformation.

Papers citation over time

A key indicator for each journal is its effectiveness in reaching other researchers with the papers published at that venue.

The chart below presents the interquartile range (first quartile 25%, median 50% and third quartile 75%) of the number of citations of articles over time.

The top authors publishing in Xenobiotica (based on the number of publications) are:

  • Hiroshi Yamazaki (81 papers) published 9 papers at the last edition, 2 more than at the previous edition,
  • Ian D. Wilson (44 papers) published 1 paper at the last edition,
  • Brian G. Lake (40 papers) published 1 paper at the last edition, 1 less than at the previous edition,
  • Stephen C. Mitchell (39 papers) published 1 paper at the last edition, 3 less than at the previous edition,
  • Rosemary H. Waring (35 papers) absent at the last edition.

The overall trend for top authors publishing in this journal is outlined below. The chart shows the number of publications at each edition of the journal for top authors.

Only papers with recognized affiliations are considered

The top affiliations publishing in Xenobiotica (based on the number of publications) are:

  • Imperial College London (134 papers) published 2 papers at the last edition, 3 less than at the previous edition,
  • Pfizer (121 papers) absent at the last edition,
  • University of Surrey (119 papers) published 1 paper at the last edition, 1 less than at the previous edition,
  • AstraZeneca (87 papers) published 1 paper at the last edition,
  • National Institutes of Health (87 papers) published 4 papers at the last edition, 2 less than at the previous edition.

The overall trend for top affiliations publishing in this journal is outlined below. The chart shows the number of publications at each edition of the journal for top affiliations.

Publication chance based on affiliation

The publication chance index shows the ratio of articles published by the best research institutions in the journal edition to all articles published within that journal. The best research institutions were selected based on the largest number of articles published during all editions of the journal.

The chart below presents the percentage ratio of articles from top institutions (based on their ranking of total papers).Top affiliations were grouped by their rank into the following tiers: top 1-10, top 11-20, top 21-50, and top 51+. Only articles with a recognized affiliation are considered.

During the most recent 2021 edition, 12.40% of publications had an unrecognized affiliation. Out of the publications with recognized affiliations, 16.81% were posted by at least one author from the top 10 institutions publishing in the journal. Another 8.85% included authors affiliated with research institutions from the top 11-20 affiliations. Institutions from the 21-50 range included 15.04% of all publications and 59.29% were from other institutions.

Returning Authors Index

A very common phenomenon observed among researchers publishing scientific articles is the intentional selection of journals they have already attended in the past. In particular, it is worth analyzing the case when the authors participate in the same journal from year to year.

The Returning Authors Index presented below illustrates the ratio of authors who participated in both a given as well as the previous edition of the journal in relation to all participants in a given year.

Returning Institution Index

The graph below shows the Returning Institution Index, illustrating the ratio of institutions that participated in both a given and the previous edition of the conference in relation to all affiliations present in a given year.

The experience to innovation index

Our experience to innovation index was created to show a cross-section of the experience level of authors publishing in a journal. The index includes the authors publishing at the last edition of a journal, grouped by total number of publications throughout their academic career (P) and the total number of citations of these publications ever received (C).

The group intervals were selected empirically to best show the diversity of the authors' experiences, their labels were selected as a convenience, not as judgment. The authors were divided into the following groups:

  • Novice - P < 5 or C < 25 (the number of publications less than 5 or the number of citations less than 25),
  • Competent - P < 10 or C < 100 (the number of publications less than 10 or the number of citations less than 100),
  • Experienced - P < 25 or C < 625 (the number of publications less than 25 or the number of citations less than 625),
  • Master - P < 50 or C < 2500 (the number of publications less than 50 or the number of citations less than 2500),
  • Star - P ≥ 50 and C ≥ 2500 (both the number of publications greater than 50 and the number of citations greater than 2500).

The chart below illustrates experience levels of first authors in cases of publications with multiple authors.

Top Publications

  • Pharmacokinetics, tissue distribution and excretion of five rhubarb anthraquinones in rats after oral administration of effective fraction of anthraquinones from rheum officinale

    (2021)
    15 Citations
  • Predictability of human pharmacokinetics of drugs that undergo hepatic organic anion transporting polypeptide (OATP)-mediated transport using single-species allometric scaling in chimeric mice with humanized liver: integration with hepatic drug metabolism.

    Seigo Sanoh;Yoichi Naritomi;Satoshi Kitamura;Akihiko Shinagawa

    (2020)
    13 Citations
  • Methyl-hydroxylation and subsequent oxidation to produce carboxylic acid is the major metabolic pathway of tolbutamide in chimeric TK-NOG mice transplanted with human hepatocytes.

    Shotaro Uehara;Nao Yoneda;Yuichiro Higuchi;Hiroshi Yamazaki

    (2021)
    12 Citations
  • Metabolism of desloratadine by chimeric TK-NOG mice transplanted with human hepatocytes.

    Shotaro Uehara;Nao Yoneda;Yuichiro Higuchi;Hiroshi Yamazaki

    (2020)
    11 Citations
  • Preference for O-demethylation reactions in the oxidation of 2′-, 3′-, and 4′-methoxyflavones by human cytochrome P450 enzymes

    Haruna Nagayoshi;Norie Murayama;Masaki Tsujino;Shigeo Takenaka

    (2020)
    9 Citations
  • Rapid determination of the pharmacokinetics and metabolic fate of gefitinib in the mouse using a combination of UPLC/MS/MS, UPLC/QToF/MS, and ion mobility (IM)-enabled UPLC/QToF/MS

    Billy J. Molloy;Adam King;Lauren G. Mullin;Lee A. Gethings

    (2021)
    9 Citations
  • Predicting successful/unsuccessful extrapolation for in vivo total clearance of model compounds with a variety of hepatic intrinsic metabolism and protein bindings in humans from pharmacokinetic data using chimeric mice with humanised liver.

    Takeshi Sawada;Yoshiyuki Yamaura;Satonori Higuchi;Haruo Imawaka

    (2020)
    8 Citations
  • Employing in vitro metabolism to guide design of F-labelled PET probes of novel α-synuclein binding bifunctional compounds.

    Chukwunonso K Nwabufo;Omozojie P Aigbogun;Kevin J H Allen;Madeline N Owens

    (2021)
    8 Citations
  • Roles of cytochrome P450 2A6 in the oxidation of flavone, 4'-hydroxyflavone, and 4'-, 3'-, and 2'-methoxyflavones by human liver microsomes.

    Haruna Nagayoshi;Norie Murayama;Shigeo Takenaka;Vitchan Kim

    (2021)
    7 Citations
  • Influence of <i>UGT2B7</i> and <i>UGT1A6</i> polymorphisms on plasma concentration to dose ratio of valproic acid in Chinese epileptic children

    (2021)
    7 Citations

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Best Scientists Contributing to This Journal