World's Best Scientists 2026 revealed!
Journal of Clinical Investigation
H-index 125

Journal of Clinical Investigation

0021-9738

Published by: American Society for Clinical Investigation (ASCI)

https://www.jci.org/

Ranking & Metrics

Discipline name Position Best Scientists Publications D-Index
Medicine 27 1579 1366 109

Additional Metrics

Number of Best Scientists*: 3964
Documents by Best Scientists*: 2253
Top 100 Ranked Scientists*: 165
SCIMAGO H-index: 558
SCIMAGO SJR: 4.721
Impact Factor: 13.6

Overview

Top Research Topics at Journal of Clinical Investigation?

The aim of Journal of Clinical Investigation is to expand the discussion of research in Internal medicine, Endocrinology, Immunology, Biochemistry and Molecular biology. The Internal medicine study featured in the journal draws connections with the study of Cardiology. It focuses on Endocrinology as well as the interrelated topic of Calcium.

Journal of Clinical Investigation encompasses presentations on Immunology, specifically Immune system, Antigen, Antibody, T cell and Inflammation. Insulin resistance is a focus of the Insulin works in it.

  • Internal medicine (38.38%)
  • Endocrinology (33.49%)
  • Immunology (17.89%)

What are the most cited papers published in the journal?

  • THE DISTRIBUTION AND CHEMICAL COMPOSITION OF ULTRACENTRIFUGALLY SEPARATED LIPOPROTEINS IN HUMAN SERUM (8080 citations)
  • Obesity is associated with macrophage accumulation in adipose tissue (7462 citations)
  • The basics of epithelial-mesenchymal transition (6729 citations)

Research areas of the most cited articles at Journal of Clinical Investigation:

The published articles facilitate discussions on Internal medicine, Endocrinology, Immunology, Molecular biology and Biochemistry. Issues in Internal medicine were discussed in the published papers, taking into consideration concepts from other disciplines like Diabetes mellitus and Cardiology. Receptor and Cell biology are some topics wherein Endocrinology research discussed in the published papers has an impact.

What topics the last edition of the journal is best known for?

  • Internal medicine
  • Gene
  • Enzyme

The previous edition focused in particular on these issues:

Journal of Clinical Investigation was organized to reinforce research efforts on Cancer research, Immunology, Immune system, Internal medicine and Cell biology. While it focused on Cancer research, it was also able to explore topics like Cancer, T cell, Downregulation and upregulation, CD8 and Cancer immunotherapy. Most of the works presented in the journal deals with Immunology but it intersects with the subject of Disease.

The studies tackled, which mainly focus on Immune system, apply to Antigen as well. The study on Internal medicine presented in it intersects with subjects under the field of Endocrinology. The research on Acquired immune system discussed in it draws on the closely related field of Immunity.

The most cited articles from the last journal are:

  • Recent endemic coronavirus infection is associated with less severe COVID-19. (92 citations)
  • SARS-CoV-2-specific CD8+ T cell responses in convalescent COVID-19 individuals. (60 citations)
  • BCG vaccination history associates with decreased SARS-CoV-2 seroprevalence across a diverse cohort of health care workers. (39 citations)

Papers citation over time

A key indicator for each journal is its effectiveness in reaching other researchers with the papers published at that venue.

The chart below presents the interquartile range (first quartile 25%, median 50% and third quartile 75%) of the number of citations of articles over time.

The top authors publishing in Journal of Clinical Investigation (based on the number of publications) are:

  • Ushma S. Neill (98 papers) published 4 papers at the last edition the same number as at the previous edition,
  • Ronald G. Crystal (60 papers) absent at the last edition,
  • Gerald I. Shulman (58 papers) absent at the last edition,
  • Eugene Braunwald (53 papers) absent at the last edition,
  • Alan R. Tall (52 papers) absent at the last edition.

The overall trend for top authors publishing in this journal is outlined below. The chart shows the number of publications at each edition of the journal for top authors.

Only papers with recognized affiliations are considered

The top affiliations publishing in Journal of Clinical Investigation (based on the number of publications) are:

  • Harvard University (1445 papers) published 36 papers at the last edition, 1 more than at the previous edition,
  • National Institutes of Health (895 papers) published 29 papers at the last edition, 1 more than at the previous edition,
  • University of Pennsylvania (603 papers) published 39 papers at the last edition, 12 more than at the previous edition,
  • Yale University (577 papers) published 21 papers at the last edition, 4 more than at the previous edition,
  • University of California, San Francisco (515 papers) published 15 papers at the last edition, 8 less than at the previous edition.

The overall trend for top affiliations publishing in this journal is outlined below. The chart shows the number of publications at each edition of the journal for top affiliations.

Publication chance based on affiliation

The publication chance index shows the ratio of articles published by the best research institutions in the journal edition to all articles published within that journal. The best research institutions were selected based on the largest number of articles published during all editions of the journal.

The chart below presents the percentage ratio of articles from top institutions (based on their ranking of total papers).Top affiliations were grouped by their rank into the following tiers: top 1-10, top 11-20, top 21-50, and top 51+. Only articles with a recognized affiliation are considered.

During the most recent 2021 edition, 16.38% of publications had an unrecognized affiliation. Out of the publications with recognized affiliations, 38.33% were posted by at least one author from the top 10 institutions publishing in the journal. Another 14.79% included authors affiliated with research institutions from the top 11-20 affiliations. Institutions from the 21-50 range included 16.88% of all publications and 30.00% were from other institutions.

Returning Authors Index

A very common phenomenon observed among researchers publishing scientific articles is the intentional selection of journals they have already attended in the past. In particular, it is worth analyzing the case when the authors participate in the same journal from year to year.

The Returning Authors Index presented below illustrates the ratio of authors who participated in both a given as well as the previous edition of the journal in relation to all participants in a given year.

Returning Institution Index

The graph below shows the Returning Institution Index, illustrating the ratio of institutions that participated in both a given and the previous edition of the conference in relation to all affiliations present in a given year.

The experience to innovation index

Our experience to innovation index was created to show a cross-section of the experience level of authors publishing in a journal. The index includes the authors publishing at the last edition of a journal, grouped by total number of publications throughout their academic career (P) and the total number of citations of these publications ever received (C).

The group intervals were selected empirically to best show the diversity of the authors' experiences, their labels were selected as a convenience, not as judgment. The authors were divided into the following groups:

  • Novice - P < 5 or C < 25 (the number of publications less than 5 or the number of citations less than 25),
  • Competent - P < 10 or C < 100 (the number of publications less than 10 or the number of citations less than 100),
  • Experienced - P < 25 or C < 625 (the number of publications less than 25 or the number of citations less than 625),
  • Master - P < 50 or C < 2500 (the number of publications less than 50 or the number of citations less than 2500),
  • Star - P ≥ 50 and C ≥ 2500 (both the number of publications greater than 50 and the number of citations greater than 2500).

The chart below illustrates experience levels of first authors in cases of publications with multiple authors.

Career Opportunities and Future Research Directions in Clinical Investigation

The field of clinical investigation is vast, offering numerous career opportunities for aspiring investigators and researchers. Wanting to pursue a career in this field requires not only a deep interest in clinical research but also substantial education and experience. For instance, becoming a registered nurse entails specific steps and requirements, making professionals in this role valuable contributors to clinical investigation. Those aiming to work in North Carolina can read further about the process how to become a registered nurse in North Carolina online.

Future research directions in clinical investigation could concern the development of personalized medicine, exploring the impact of genome sequencing for disease prediction and treatment, or investigating the roles of gut microbiota in human health. As treatment methodologies advance, so does our understanding of the intricate interplay of effectors and factors in disease promotion and prevention.

Essentially, continuous exploration and multi-disciplinary collaboration would pave the way for advances in clinical investigation research. Furthermore, fostering a new generation of investigators/experts through a deep understanding of foundational topics such as internal medicine, endocrinology, and immunology would be crucial in achieving this endeavor.

Top Publications

  • Deployment of convalescent plasma for the prevention and treatment of COVID-19.

    Evan M. Bloch;Shmuel Shoham;Arturo Casadevall;Bruce S. Sachais

    (2020)
    945 Citations
  • Immune responses to stroke: mechanisms, modulation, and therapeutic potential.

    Costantino Iadecola;Marion S. Buckwalter;Josef Anrather

    (2020)
    766 Citations
  • Kinetics of viral load and antibody response in relation to COVID-19 severity.

    Yanqun Wang;Lu Zhang;Ling Sang;Feng Ye

    (2020)
    567 Citations
  • Insulin resistance drives hepatic de novo lipogenesis in nonalcoholic fatty liver disease.

    Gordon I. Smith;Mahalakshmi Shankaran;Mihoko Yoshino;George G. Schweitzer

    (2020)
    509 Citations
  • Early safety indicators of COVID-19 convalescent plasma in 5000 patients.

    Michael J. Joyner;R. Scott Wright;Delisa Fairweather;Jonathon W. Senefeld

    (2020)
    505 Citations
  • SARS-CoV-2 infection of the placenta.

    Hillary Hosier;Shelli F. Farhadian;Raffaella A. Morotti;Uma Deshmukh

    (2020)
    499 Citations
  • Impaired immune cell cytotoxicity in severe COVID-19 is IL-6 dependent.

    Alessio Mazzoni;Lorenzo Salvati;Laura Maggi;Manuela Capone

    (2020)
    498 Citations
  • Sex, age, and hospitalization drive antibody responses in a COVID-19 convalescent plasma donor population.

    Sabra L. Klein;Andrew Pekosz;Han Sol Park;Rebecca L. Ursin

    (2020)
    454 Citations
  • Hypoxia-inducible factors: cancer progression and clinical translation

    (2022)
    415 Citations
  • Multisystem inflammatory syndrome in children and COVID-19 are distinct presentations of SARS-CoV-2.

    Caroline Diorio;Sarah E. Henrickson;Laura A. Vella;Kevin O. McNerney

    (2020)
    408 Citations

Related Online Degrees & Career Pathways

For those considering a medical career, exploring online degrees can offer flexible pathways to advance in the healthcare field. Programs like the capella university vs wgu rn to bsn provide options to earn a Bachelor of Science in Nursing (BSN) with varying approaches to clinical requirements and cost. Choosing the right program depends on your learning preferences, career goals, and accreditation.

Bridging from RN to advanced degrees is also a popular route. Several affordable and accredited rn to msn bridge programs are designed to upgrade skills and open doors to leadership and specialized roles in healthcare. These programs often blend flexible online coursework with hands-on clinical practice.

For working professionals or those with time constraints, enrolling in an rn to bsn with no clinical hours program can minimize onsite requirements without sacrificing educational quality. This option is particularly valuable for experienced nurses seeking degree advancement.

Finally, for nurses aiming for the highest clinical practice level, accelerated paths such as the 1 year msn to dnp program online offer the opportunity to earn a Doctor of Nursing Practice in a condensed timeframe. These advanced degrees enable expanded roles in healthcare delivery and policy-making.

Best Scientists Contributing to This Journal

Recently Published Articles