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Gene Therapy
H-index 27

Gene Therapy

0969-7128

Published by: Springer

https://www.nature.com/gt/

Ranking & Metrics

Discipline name Position Best Scientists Publications D-Index
Molecular Biology 71 26 32 16
Genetics 88 16 24 11
Microbiology 228 10 12 8
Medicine 1150 59 71 21

Additional Metrics

Number of Best Scientists*: 208
Documents by Best Scientists*: 166
Top 100 Ranked Scientists*: 5
SCIMAGO H-index: 177
SCIMAGO SJR: 1.784
Impact Factor: 4.5

Overview

Top Research Topics at Gene Therapy?

The journal aims to foster the development of research in Genetic enhancement, Molecular biology, Virology, Immunology and Gene delivery. The research on Genetic enhancement featured in Gene Therapy combines topics in other fields like Transgene, Cancer research, Viral vector and Gene expression. The research on Cancer research tackled can also make contributions to studies in the areas of Apoptosis, Cancer, Suicide gene and Pathology.

The Molecular biology works featured in the journal incorporate elements from Cell culture, Gene, Transfection, Reporter gene and In vivo. It addresses concerns in Transfection which are intertwined with other disciplines, such as Plasmid and DNA. In the journal, Vector (molecular biology), Adenoviridae and Transduction (genetics) are investigated in conjunction with one another to address concerns in Virology research.

The Immunology study tackled is a key component of adjacent topics in the area of Cytotoxic T cell. While Gene delivery is the focus of the journal, it also provided insights into the studies of Gene transfer and Cell biology. Most of the works presented in Gene Therapy deals with Genetic transfer but it intersects with the subject of Internal medicine.

  • Genetic enhancement (50.08%)
  • Molecular biology (28.31%)
  • Virology (21.81%)

What are the most cited papers published in the journal?

  • Hydrodynamics-based transfection in animals by systemic administration of plasmid DNA (1542 citations)
  • Plat-E: an efficient and stable system for transient packaging of retroviruses. (1423 citations)
  • Recombinant adeno-associated virus purification using novel methods improves infectious titer and yield (1137 citations)

Research areas of the most cited articles at Gene Therapy:

The published articles cover a variety of subjects, including Genetic enhancement, Molecular biology, Genetic transfer, Gene delivery and Virology. The most cited papers deal with Genetic enhancement in conjunction with Immunology and similar fields in Cytotoxic T cell. The published articles explore issues in Molecular biology which can be linked to other research areas like Reporter gene, Gene expression, DNA, Transfection and In vivo.

What topics the last edition of the journal is best known for?

  • Gene
  • Internal medicine
  • Enzyme

The previous edition focused in particular on these issues:

Gene Therapy is organized to address concerns in the fields of Genetic enhancement, Cancer research, Gene, Cell biology and Transgene. The journal holds forums on Genetic enhancement that merges themes from other disciplines such as Bioinformatics, Vector (molecular biology), Virus, Viral vector and Transduction (genetics). While the journal focused on Cancer research, it was also able to explore topics like Cell culture, Gene expression, Downregulation and upregulation, Drug delivery and In vivo.

The tackled In vivo research is interrelated with Gene delivery which concerns subjects like Neuroscience. The study of Transgene encompasses disciplines such as Molecular biology, as well as fields such as DNA and Apoptosis, all of which overlap with one another. The journal explores issues in Genome editing which can be linked to other research areas like Transfection and Virology.

The most cited articles from the last journal are:

  • Optimization of adeno-associated viral vector-mediated transduction of the corticospinal tract: comparison of four promoters. (14 citations)
  • Current status and perspective of CAR-T and CAR-NK cell therapy trials in Germany (13 citations)
  • Nr2e3 is a genetic modifier that rescues retinal degeneration and promotes homeostasis in multiple models of retinitis pigmentosa. (12 citations)

Papers citation over time

A key indicator for each journal is its effectiveness in reaching other researchers with the papers published at that venue.

The chart below presents the interquartile range (first quartile 25%, median 50% and third quartile 75%) of the number of citations of articles over time.

The top authors publishing in Gene Therapy (based on the number of publications) are:

  • David T. Curiel (58 papers) absent at the last edition,
  • Paul D. Robbins (55 papers) absent at the last edition,
  • Yasufumi Kaneda (49 papers) absent at the last edition,
  • Joseph C. Glorioso (43 papers) absent at the last edition,
  • Leaf Huang (40 papers) absent at the last edition.

The overall trend for top authors publishing in this journal is outlined below. The chart shows the number of publications at each edition of the journal for top authors.

Only papers with recognized affiliations are considered

The top affiliations publishing in Gene Therapy (based on the number of publications) are:

  • University of Pittsburgh (219 papers) absent at the last edition,
  • National Institutes of Health (149 papers) published 6 papers at the last edition, 5 more than at the previous edition,
  • Imperial College London (112 papers) absent at the last edition,
  • French Institute of Health and Medical Research (106 papers) published 3 papers at the last edition,
  • Harvard University (99 papers) published 2 papers at the last edition, 1 more than at the previous edition.

The overall trend for top affiliations publishing in this journal is outlined below. The chart shows the number of publications at each edition of the journal for top affiliations.

Publication chance based on affiliation

The publication chance index shows the ratio of articles published by the best research institutions in the journal edition to all articles published within that journal. The best research institutions were selected based on the largest number of articles published during all editions of the journal.

The chart below presents the percentage ratio of articles from top institutions (based on their ranking of total papers).Top affiliations were grouped by their rank into the following tiers: top 1-10, top 11-20, top 21-50, and top 51+. Only articles with a recognized affiliation are considered.

During the most recent 2021 edition, 5.98% of publications had an unrecognized affiliation. Out of the publications with recognized affiliations, 10.91% were posted by at least one author from the top 10 institutions publishing in the journal. Another 6.36% included authors affiliated with research institutions from the top 11-20 affiliations. Institutions from the 21-50 range included 20.00% of all publications and 62.73% were from other institutions.

Returning Authors Index

A very common phenomenon observed among researchers publishing scientific articles is the intentional selection of journals they have already attended in the past. In particular, it is worth analyzing the case when the authors participate in the same journal from year to year.

The Returning Authors Index presented below illustrates the ratio of authors who participated in both a given as well as the previous edition of the journal in relation to all participants in a given year.

Returning Institution Index

The graph below shows the Returning Institution Index, illustrating the ratio of institutions that participated in both a given and the previous edition of the conference in relation to all affiliations present in a given year.

The experience to innovation index

Our experience to innovation index was created to show a cross-section of the experience level of authors publishing in a journal. The index includes the authors publishing at the last edition of a journal, grouped by total number of publications throughout their academic career (P) and the total number of citations of these publications ever received (C).

The group intervals were selected empirically to best show the diversity of the authors' experiences, their labels were selected as a convenience, not as judgment. The authors were divided into the following groups:

  • Novice - P < 5 or C < 25 (the number of publications less than 5 or the number of citations less than 25),
  • Competent - P < 10 or C < 100 (the number of publications less than 10 or the number of citations less than 100),
  • Experienced - P < 25 or C < 625 (the number of publications less than 25 or the number of citations less than 625),
  • Master - P < 50 or C < 2500 (the number of publications less than 50 or the number of citations less than 2500),
  • Star - P ≥ 50 and C ≥ 2500 (both the number of publications greater than 50 and the number of citations greater than 2500).

The chart below illustrates experience levels of first authors in cases of publications with multiple authors.

Top Publications

  • CARAMBA: a first-in-human clinical trial with SLAMF7 CAR-T cells prepared by virus-free Sleeping Beauty gene transfer to treat multiple myeloma.

    Sabrina Prommersberger;Michael Reiser;Michael Reiser;Julia Beckmann;Sophia Danhof

    (2021)
    166 Citations
  • Gene therapy and gene correction: targets, progress, and challenges for treating human diseases.

    Matthew R Cring;Val C Sheffield

    (2020)
    92 Citations
  • Integrating gene delivery and gene-editing technologies by adenoviral vector transfer of optimized CRISPR-Cas9 components.

    Ignazio Maggio;Hidde A Zittersteijn;Qian Wang;Jin Liu

    (2020)
    51 Citations
  • Antisense oligonucleotides as a potential treatment for brain deficits observed in myotonic dystrophy type 1

    (2022)
    50 Citations
  • Investigation of the safety and feasibility of AAV1/SERCA2a gene transfer in patients with chronic heart failure supported with a left ventricular assist device - the SERCA-LVAD TRIAL.

    A R Lyon;D Babalis;A C Morley-Smith;M Hedger

    (2020)
    49 Citations
  • Correction of X-CGD patient HSPCs by targeted CYBB cDNA insertion using CRISPR/Cas9 with 53BP1 inhibition for enhanced homology-directed repair.

    Colin L Sweeney;Mara Pavel-Dinu;Uimook Choi;Julie Brault

    (2021)
    48 Citations

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