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Biology and Biochemistry

D-Index
61
Citations
16777
World Ranking
11200
National Ranking
4846

Overview

Paul E. Hardin is affiliated with Texas A&M University in the United States. Their research primarily focuses on the fields of neuroscience and biochemistry, genetics, and molecular biology, with a strong emphasis on circadian rhythm and melatonin. Other key topics in their work include genetics, aging, and longevity in model organisms, photosynthetic processes and mechanisms, and neurobiology and insect physiology research.

The scientist's work spans several subfields, including endocrine and autonomic systems, aging, molecular biology, cellular and molecular neuroscience, and plant science. Their publication record includes articles in notable scientific journals such as Nature, Current Biology, iScience, Scientific Reports, and Frontiers in Systems Neuroscience.

Recent papers authored or co-authored by Paul E. Hardin cover a range of circadian biology topics:

  • CLOCKWORK ORANGE promotes CLOCK-CYCLE activation via the putative Drosophila ortholog of CLOCK INTERACTING PROTEIN CIRCADIAN (2021, Current Biology)
  • Crosstalk between vrille transcripts, proteins, and regulatory elements controlling circadian rhythms and development in Drosophila (2020, iScience)
  • Proteomic analysis of Drosophila CLOCK complexes identifies rhythmic interactions with SAGA and Tip60 complex component NIPPED-A (2020, Scientific Reports)
  • The P-loop NTPase RUVBL2 is a conserved clock component across eukaryotes (2025, Nature)
  • TRITHORAX-dependent arginine methylation of HSP68 mediates circadian repression by PERIOD in the monarch butterfly (2022, Proceedings of the National Academy of Sciences)

Frequent collaborators include Gustavo Bueno da Silva Rivas, Meimei Liao, Yanqin Liu, Zhancong Xu, and Mingxu Fang. Their repeated collaborations suggest a sustained research partnership in areas related to circadian rhythm and molecular mechanisms underpinning biological clocks.

Their regular contributions to venues such as Nature (2 publications), Current Biology, iScience, Scientific Reports, and Frontiers in Systems Neuroscience underline their active involvement in disseminating research findings within the neuroscience and molecular biology communities.

Best Publications

  • CIRCADIAN RHYTHMS FROM MULTIPLE OSCILLATORS: LESSONS FROM DIVERSE ORGANISMS

    Deborah Bell-Pedersen;Vincent M. Cassone;David J. Earnest;David J. Earnest;Susan S. Golden

  • Feedback of the Drosophila period gene product on circadian cycling of its messenger RNA levels

    Paul E. Hardin;Jeffrey C. Hall;Michael Rosbash;Michael Rosbash

  • vrille, Pdp1, and dClock form a second feedback loop in the Drosophila circadian clock

    Shawn A. Cyran;Anna M. Buchsbaum;Karen L. Reddy;Meng Chi Lin

  • The circadian timekeeping system of Drosophila.

    Paul E. Hardin

  • Interlocked feedback loops within the Drosophila circadian oscillator.

    Nick R. J. Glossop;Lisa C. Lyons;Paul E. Hardin

  • How a circadian clock adapts to seasonal decreases in temperature and day length.

    John Majercak;David Sidote;Paul E. Hardin;Isaac Edery;Isaac Edery

  • Molecular genetic analysis of circadian timekeeping in Drosophila.

    Paul E. Hardin

  • Disruption of the circadian clock within the cardiomyocyte influences myocardial contractile function, metabolism, and gene expression

    Molly S. Bray;Chad A. Shaw;Michael W.S. Moore;Rodrigo A.P. Garcia;Rodrigo A.P. Garcia

  • VRILLE feeds back to control circadian transcription of Clock in the Drosophila circadian oscillator

    Nicholas R.J. Glossop;Jerry H. Houl;Hao Zheng;Fanny S. Ng

  • A promoterless period gene mediates behavioral rhythmicity and cyclical per expression in a restricted subset of the Drosophila nervous system.

    Brigitte Frisch;Paul E. Hardin;Paul E. Hardin;Melanie J. Hamblen-Coyle;Michael Rosbash;Michael Rosbash

  • Circadian rhythms in olfactory responses of Drosophila melanogaster

    Balaji Krishnan;Stuart E. Dryer;Paul E. Hardin

  • A circadian enhancer mediates PER-dependent mRNA cycling in Drosophila melanogaster.

    Haiping Hao;David L. Allen;Paul E. Hardin

  • Circadian oscillations in period gene mRNA levels are transcriptionally regulated.

    Paul E. Hardin;Jeffrey C. Hall;Michael Rosbash

  • PER-dependent rhythms in CLK phosphorylation and E-box binding regulate circadian transcription.

    Wangjie Yu;Hao Zheng;Jerry H. Houl;Brigitte Dauwalder

  • A new role for cryptochrome in a Drosophila circadian oscillator

    Balaji Krishnan;Joel D. Levine;M. Kathlea S. Lynch;Harold B. Dowse

  • Constitutive overexpression of the Drosophila period protein inhibits period mRNA cycling.

    Hongkui Zeng;P. E. Hardin;M. Rosbash

  • Defining the role of Drosophila lateral neurons in the control of circadian rhythms in motor activity and eclosion by targeted genetic ablation and PERIOD protein overexpression.

    Eric Blanchardon;Brigitte Grima;André Klarsfeld;Elisabeth Chélot

  • The intrinsic circadian clock within the cardiomyocyte

    David J. Durgan;Margaret A. Hotze;Tara M. Tomlin;Oluwaseun Egbejimi

  • Circadian clocks in antennal neurons are necessary and sufficient for olfaction rhythms in Drosophila.

    Shintaro Tanoue;Parthasarathy Krishnan;Balaji Krishnan;Stuart E Dryer

  • Circadian timekeeping and output mechanisms in animals

    Paul E Hardin;Satchidananda Panda

Frequent Co-Authors

Michael Rosbash
Michael Rosbash Brandeis University
Jeffrey C. Hall
Jeffrey C. Hall Brandeis University
Stuart E. Dryer
Stuart E. Dryer University of Houston
William H. Klein
William H. Klein The University of Texas MD Anderson Cancer Center
Martin E. Young
Martin E. Young University of Alabama at Birmingham
Chad A. Shaw
Chad A. Shaw Baylor College of Medicine
Robert S. Chapkin
Robert S. Chapkin Texas A&M University
Ian A. Prior
Ian A. Prior University of Liverpool
Steve A. Kay
Steve A. Kay University of Southern California
Laurence J. Zwiebel
Laurence J. Zwiebel Vanderbilt University

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