Matthias Götte

Best Publications

• Remdesivir is a direct-acting antiviral that inhibits RNA-dependent RNA polymerase from severe acute respiratory syndrome coronavirus 2 with high potency

  Unknown

  1002
  Citations

• The antiviral compound remdesivir potently inhibits RNA-dependent RNA polymerase from Middle East respiratory syndrome coronavirus

  Unknown

  878
  Citations

• Mechanism of Inhibition of Ebola Virus RNA-Dependent RNA Polymerase by Remdesivir

  Unknown

  640
  Citations

• Mutations in the SARS-CoV-2 RNA dependent RNA polymerase confer resistance to remdesivir by distinct mechanisms

  Unknown

  335
  Citations

• Molnupiravir promotes SARS-CoV-2 mutagenesis via the RNA template.

  Calvin J. Gordon;Egor P. Tchesnokov;Raymond F. Schinazi;Matthias Götte

  281
  Citations

• Nucleic acid polymerases use a general acid for nucleotidyl transfer.

  Christian Castro;Eric D. Smidansky;Jamie J. Arnold;Kenneth R. Maksimchuk

  274
  Citations

• The M184V Mutation in the Reverse Transcriptase of Human Immunodeficiency Virus Type 1 Impairs Rescue of Chain-Terminated DNA Synthesis

  Matthias Götte;Dominique Arion;Michael A. Parniak;Mark A. Wainberg;Mark A. Wainberg

  248
  Citations

• Two proton transfers in the transition state for nucleotidyl transfer catalyzed by RNA- and DNA-dependent RNA and DNA polymerases

  Christian Castro;Eric Smidansky;Kenneth R. Maksimchuk;Jamie J. Arnold

  236
  Citations

• Direct-acting antiviral agents for hepatitis C: structural and mechanistic insights

  Matthias Götte;Jordan J. Feld

  216
  Citations

• HIV-1 reverse transcription: a brief overview focused on structure-function relationships among molecules involved in initiation of the reaction.

  Matthias Götte;Xuguang Li;Mark A. Wainberg

  206
  Citations

• Contribution of a mutational bias in hepatitis C virus replication to the genetic barrier in the development of drug resistance

  Megan H. Powdrill;Egor P. Tchesnokov;Robert A. Kozak;Rodney S. Russell

  185
  Citations

• Template-dependent inhibition of coronavirus RNA-dependent RNA polymerase by remdesivir reveals a second mechanism of action

  Unknown

  161
  Citations

• Acyclovir Is Activated into a HIV-1 Reverse Transcriptase Inhibitor in Herpesvirus-Infected Human Tissues

  Andrea Lisco;Christophe Vanpouille;Egor P. Tchesnokov;Jean Charles Grivel

  147
  Citations

• Zika Virus Hijacks Stress Granule Proteins and Modulates the Host Stress Response

  Shangmei Hou;Anil Kumar;Zaikun Xu;Adriana M. Airo

  134
  Citations

• HIV-1 reverse transcriptase-associated RNase H cleaves RNA/RNA in arrested complexes: implications for the mechanism by which RNase H discriminates between RNA/RNA and RNA/DNA.

  M. Gotte;S. Fackler;T. Hermann;E. Perola

  123
  Citations

• Indolopyridones Inhibit Human Immunodeficiency Virus Reverse Transcriptase with a Novel Mechanism of Action

  Dirk Jochmans;Jérôme Deval;Bart Kesteleyn;Herwig Van Marck

  114
  Citations

• Molecular Impact of the M184V Mutation in Human Immunodeficiency Virus Type 1 Reverse Transcriptase

  Karidia Diallo;Matthias Götte;Matthias Götte;M. A. Wainberg;M. A. Wainberg

  103
  Citations

• The L74V mutation in human immunodeficiency virus type 1 reverse transcriptase counteracts enhanced excision of zidovudine monophosphate associated with thymidine analog resistance mutations.

  Luis R. Miranda;Matthias Götte;Daniel R. Kuritzkes

  92
  Citations

• Site-specific Footprinting Reveals Differences in the Translocation Status of HIV-1 Reverse Transcriptase

  Unknown

  92
  Citations

• Vinylogous ureas as a novel class of inhibitors of reverse transcriptase-associated ribonuclease H activity.

  Michaela Wendeler;Hsiu-Fang Lee;Alun Bermingham;Jennifer T. Miller

  89
  Citations