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45
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7343
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6943
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52

Overview

Luiz E. Mello is affiliated with the Federal University of Sao Paulo in Brazil. Their research contributions primarily fall within the field of Medicine, with significant focus on Pediatrics, Perinatology and Child Health, Psychiatry and Mental Health, Neurology, Cellular and Molecular Neuroscience, and Molecular Biology.

The scientist's work is concentrated on several specific topics, such as epilepsy research and treatment, traumatic brain injury and neurovascular disturbances, neuroscience and neuropharmacology research, pharmacological effects and toxicity studies, neonatal and fetal brain pathology, extracellular vesicles in disease, and anesthesia and neurotoxicity research.

Luiz E. Mello has published in a variety of academic venues, with multiple papers appearing in:

  • European Journal of Preventive Cardiology
  • Brazilian Journal of Medical and Biological Research
  • Frontiers in Neuroscience
  • European Neuropsychopharmacology
  • Frontiers in Cellular Neuroscience

The following recent papers illustrate the breadth of their research interests and contributions:

  • Lipopolysaccharide-Induced Systemic Inflammation in the Neonatal Period Increases Microglial Density and Oxidative Stress in the Cerebellum of Adult Rats, 2020, Frontiers in Cellular Neuroscience
  • Modeling of post-traumatic epilepsy and experimental research aimed at its prevention, 2020, Brazilian Journal of Medical and Biological Research
  • Two decades of research towards a potential first anti-epileptic drug, 2021, Seizure
  • Anxious Profile Influences Behavioral and Immunohistological Findings in the Pilocarpine Model of Epilepsy, 2021, Frontiers in Pharmacology
  • Biperiden for prevention of post-traumatic epilepsy: A protocol of a double-blinded placebo-controlled randomized clinical trial (BIPERIDEN trial), 2022, PLoS ONE

Frequent collaborators include Maira Licia Foresti, Maria da Graça Naffah-Mazzacoratti, Eliana Garzón, Viviam Sanabria, and Michele Longoni Calió. These partnerships often reflect interdisciplinary approaches and ongoing projects aligned with illness treatment and neurological research.

The scientist's work spans complex biological mechanisms and clinical approaches, with a focus on both experimental models and clinical trials. The areas of epilepsy research and traumatic brain injury represent core elements, addressing both the underlying neurobiological factors and potential therapeutic interventions.

Best Publications

  • Circuit Mechanisms of Seizures in the Pilocarpine Model of Chronic Epilepsy: Cell Loss and Mossy Fiber Sprouting

    Luiz E. A. M. Mello;Esper A. Cavalheiro;Aiko M. Tan;William R. Kupfer

  • Meditation training increases brain efficiency in an attention task.

    Elisa H. Kozasa;João Ricardo Sato;João Ricardo Sato;Shirley S. Lacerda;Maria A. M. Barreiros

  • Temporal profile of neuronal injury following pilocarpine or kainic acid-induced status epilepticus.

    L Covolan;L.E.A.M Mello

  • Cell damage and neurogenesis in the dentate granule cell layer of adult rats after pilocarpine- or kainate-induced status epilepticus

    L. Covolan;L.T.C. Ribeiro;B.M. Longo;L.E.A.M. Mello

  • Blockade of pilocarpine- or kainate-induced mossy fiber sprouting by cycloheximide does not prevent subsequent epileptogenesis in rats.

    Beatriz M Longo;Luiz E.A.M Mello

  • Neuroethological and morphological (Neo-Timm staining) correlates of limbic recruitment during the development of audiogenic kindling in seizure susceptible Wistar rats.

    N. Garcia-Cairasco;H. Wakamatsu;J.A.C. Oliveira;E.L.T. Gomes

  • Therapeutic effects of the transplantation of VEGF overexpressing bone marrow mesenchymal stem cells in the hippocampus of murine model of Alzheimer's disease.

    Karina O. Garcia;Felipe L. M. Ornellas;Priscila K. Matsumoto Martin;Camilla L. Patti

  • Bilateral anterior thalamic nucleus lesions and high-frequency stimulation are protective against pilocarpine-induced seizures and status epilepticus.

    Clement Hamani;Flavio I.S. Ewerton;Saulo M. Bonilha;Gerson Ballester

  • Deep brain stimulation of the anterior nucleus of the thalamus: effects of electrical stimulation on pilocarpine-induced seizures and status epilepticus.

    Clement Hamani;Mojgan Hodaie;Mojgan Hodaie;Jason Chiang;Martin del Campo

  • Novel perspectives of neural stem cell differentiation: from neurotransmitters to therapeutics.

    Cleber Augusto Trujillo;Telma Tiemi Schwindt;Antonio Henrique Martins;Janaina Maria Alves

  • Supragranular mossy fiber sprouting is not necessary for spontaneous seizures in the intrahippocampal kainate model of epilepsy in the rat

    Beatriz M Longo;Luiz E.A.M Mello

  • Granule cell dispersion in relation to mossy fiber sprouting, hippocampal cell loss, silent period and seizure frequency in the pilocarpine model of epilepsy.

    Mello Le;Cavalheiro Ea;Tan Am;Pretorius Jk

  • Susceptibility to seizures produced by pilocarpine in rats after microinjection of isonnazid or γ-vinyl-GABA into the substantia nigra

    Lechoslaw Turski;Esper A. Cavalheiro;Michael Schwarz;Waldemar A. Turski

  • Chemically-induced RAT mesenchymal stem cells adopt molecular properties of neuronal-like cells but do not have basic neuronal functional properties.

    Gabriela F. Barnabé;Telma T. Schwindt;Maria E. Calcagnotto;Fabiana L. Motta

  • CHAPTER 35 – The Pilocarpine Model of Seizures

    Esper A. Cavalheiro;Maria G. Naffah-Mazzacoratti;Luiz E. Mello;João P. Leite

  • Anterior thalamus deep brain stimulation at high current impairs memory in rats

    Clement Hamani;Francisco P. Dubiela;Juliana C.K. Soares;Damian Shin

  • IMPACT, a Protein Preferentially Expressed in the Mouse Brain, Binds GCN1 and Inhibits GCN2 Activation

    Cátia M. Pereira;Evelyn Sattlegger;Hao Yuan Jiang;Beatriz M. Longo

  • Assessment of seizure susceptibility in pilocarpine epileptic and nonepileptic Wistar rats and of seizure reinduction with pentylenetetrazole and electroshock models

    Miriam Marcela Blanco;Jair Guilherme dos Santos;Patrícia Perez-Mendes;Silvia R. B. Kohek

  • The pattern of c-Fos expression and its refractory period in the brain of rats and monkeys.

    Vanessa N. Barros;Mayara Mundim;Layla Testa Galindo;Simone Bittencourt

  • Convergence of projections from the rat hippocampal formation, medial geniculate and basal forebrain onto single amygdaloid neurons: an in vivo extra- and intracellular electrophysiological study.

    Luiz E.A.M. Mello;Aiko M. Tan;David M. Finch

  • Transplant of GABAergic Precursors Restores Hippocampal Inhibitory Function in a Mouse Model of Seizure Susceptibility

    Ivan Zipancic;María Elisa Calcagnotto;Marina Piquer-Gil;Luiz E. Mello

Frequent Co-Authors

Esper A. Cavalheiro
Esper A. Cavalheiro Federal University of Sao Paulo
João Ricardo Sato
João Ricardo Sato Universidade Federal do ABC
Clement Hamani
Clement Hamani University of Toronto
Andres M. Lozano
Andres M. Lozano University of Toronto
Rosalia Mendez-Otero
Rosalia Mendez-Otero Federal University of Rio de Janeiro
Edson Amaro
Edson Amaro Universidade de São Paulo
Thomas L. Babb
Thomas L. Babb Wayne State University
Roberto Frussa-Filho
Roberto Frussa-Filho Federal University of Sao Paulo
Mojgan Hodaie
Mojgan Hodaie University of Toronto
Deborah Suchecki
Deborah Suchecki Federal University of Sao Paulo

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