Derek N. Middlemiss

Best Publications

• Baclofen decreases neurotransmitter release in the mammalian CNS by an action at a novel GABA receptor

  N. G. Bowery;D. R. Hill;A. L. Hudson;A. Doble

  1569
  Citations

• Proposals for the classification and nomenclature of functional receptors for 5-hydroxytryptamine

  P.B. Bradley;G. Engel;W. Feniuk;J.R. Fozard

  1408
  Citations

• 8-Hydroxy-2-(di-n-propylamino)-tetralin discriminates between subtypes of the 5-HT1 recognition site.

  Derek N. Middlemiss;John R. Fozard

  1290
  Citations

• SB 242084, a selective and brain penetrant 5-HT2C receptor antagonist.

  G.A. Kennett;M.D. Wood;F. Bright;B. Trail

  786
  Citations

• Species differences in the pharmacology of terminal 5-HT autoreceptors in mammalian brain

  Daniel Hoyer;Derek N. Middlemiss

  377
  Citations

• A functional correlate for the dihydropyridine binding site in rat brain.

  D. N. Middlemiss;M. Spedding

  360
  Citations

• Pharmacological actions of a novel, high-affinity, and selective human dopamine D(3) receptor antagonist, SB-277011-A.

  Reavill C;Taylor Sg;Wood;Ashmeade T

  354
  Citations

• Characterization of SB‐269970‐A, a selective 5‐HT7 receptor antagonist

  Jim J Hagan;Gary W Price;Phillip Jeffrey;Nigel J Deeks

  348
  Citations

• Dopamine D3 Receptor Antagonism Inhibits Cocaine-Seeking and Cocaine-Enhanced Brain Reward in Rats

  Stanislav R. Vorel;Charles R. Ashby;Mousumi Paul;Xinhe Liu

  343
  Citations

• Stereoselective blockade at [3H]5-HT binding sites and at the 5-HT autoreceptor by propranolol

  Derek N. Middlemiss

  295
  Citations

• Cardiovascular response to 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT) in the rat: site of action and pharmacological analysis.

  John R. Fozard;Anis K. Mir;Derek N. Middlemiss

  295
  Citations

• Direct evidence for an interaction of β-adrenergic blockers with the 5-HT receptor

  Unknown

  274
  Citations

• Characterization of recombinant human orexin receptor pharmacology in a Chinese hamster ovary cell‐line using FLIPR

  D Smart;J C Jerman;S J Brough;S L Rushton

  271
  Citations

• 5-Chloro-N-(4-methoxy-3-piperazin-1-yl- phenyl)-3-methyl-2-benzothiophenesulfon- amide (SB-271046): a potent, selective, and orally bioavailable 5-HT6 receptor antagonist.

  Steven M. Bromidge;Anthony M. Brown;Stephen E. Clarke;Kathy Dodgson

  262
  Citations

• Graphics computer-aided receptor mapping as a predictive tool for drug design: development of potent, selective, and stereospecific ligands for the 5-HT1A receptor

  Marcel F. Hibert;Maurice W. Gittos;Derek N. Middlemiss;Anis K. Mir

  243
  Citations

• SB-216641 and BRL-15572--compounds to pharmacologically discriminate h5-HT1B and h5-HT1D receptors.

  G. W. Price;M. J. Burton;L. J. Collin;M. Duckworth

  235
  Citations

• Molecular cloning of a serotonin receptor from human brain (5HT1E): a fifth 5HT1-like subtype.

  G McAllister;A Charlesworth;C Snodin;M S Beer

  230
  Citations

• The expression of GABAB1 and GABAB2 receptor subunits in the cNS differs from that in peripheral tissues

  A.R. Calver;A.D. Medhurst;M.J. Robbins;K.J. Charles

  219
  Citations

• Characterization of SB-271046 : A potent, selective and orally active 5-HT6 receptor antagonist

  Carol Routledge;Steven M Bromidge;Stephen F Moss;Gary W Price

  212
  Citations

• Subtypes of the 5-HT receptor mediating the behavioural responses to 5-methoxy-N,N-dimethyltryptamine in the rat.

  Mark D. Tricklebank;Christian Forler;Derek N. Middlemiss;John R. Fozard

  202
  Citations