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Genetics

D-Index
79
Citations
48631
World Ranking
1607
National Ranking
209

Overview

David Curtis is affiliated with Queen Mary University of London in the United Kingdom. Their primary areas of research lie within Biochemistry, Genetics and Molecular Biology, and Medicine. The scientist's work extends to several subfields, including Genetics, Molecular Biology, Surgery, Psychiatry and Mental Health, and Physiology.

Their research topics cover a diverse range of genetic and molecular biology issues, with a particular focus on Genetic Associations and Epidemiology, Genomics and Rare Diseases, Genetics and Neurodevelopmental Disorders, Genomic Variations and Chromosomal Abnormalities, Epigenetics and DNA Methylation, Lipoproteins and Cardiovascular Health, and BRCA Gene Mutations in Cancer.

David Curtis has published extensively in various scientific venues. Their frequent publication outlets include bioRxiv (Cold Spring Harbor Laboratory) with 21 publications, UNC Libraries with 6, Annals of Human Genetics and Psychiatric Genetics with 5 each, and Human Heredity with 4 publications.

The scientist has collaborated closely with several frequent co-authors, notably James Walters, Aiden Corvin, Michael O'Donovan, Tim B. Bigdeli, and Nicholas Bass, reflecting ongoing partnerships within the genetics and psychiatric genetics research communities.

Notable recent publications include:

  • Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology (2021, Nature Genetics)
  • Rare coding variants in ten genes confer substantial risk for schizophrenia (2022, Nature)
  • Exome sequencing in bipolar disorder identifies AKAP11 as a risk gene shared with schizophrenia (2022, Nature Genetics)
  • Interaction Testing and Polygenic Risk Scoring to Estimate the Association of Common Genetic Variants With Treatment Resistance in Schizophrenia (2022, JAMA Psychiatry)
  • Pseudouridylation defect due to DKC1 and NOP10 mutations causes nephrotic syndrome with cataracts, hearing impairment, and enterocolitis (2020, Proceedings of the National Academy of Sciences)

Best Publications

  • Biological insights from 108 schizophrenia-associated genetic loci

    Stephan Ripke;Stephan Ripke;Benjamin M. Neale;Benjamin M. Neale;Aiden Corvin;James T. R. Walters

  • Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs

    S. Hong Lee;Stephan Ripke;Stephan Ripke;Benjamin M. Neale;Benjamin M. Neale;Stephen V. Faraone

  • Analysis of shared heritability in common disorders of the brain

    Verneri Anttila;Verneri Anttila;Brendan Bulik-Sullivan;Brendan Bulik-Sullivan;Hilary K. Finucane;Raymond K. Walters;Raymond K. Walters

  • Genome-wide association study identifies 30 loci associated with bipolar disorder

    Eli A. Stahl;Eli A. Stahl;Gerome Breen;Andreas J. Forstner;Andrew McQuillin

  • Modeling Linkage Disequilibrium Increases Accuracy of Polygenic Risk Scores

    Bjarni J. Vilhjálmsson;Jian Yang;Hilary K. Finucane;Alexander Gusev

  • Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology

    Niamh Mullins;Andreas J. Forstner;Andreas J. Forstner;Andreas J. Forstner;Kevin S. O'Connell;Kevin S. O'Connell;Brandon Coombes

  • Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder

    Manuel A R Ferreira;Michael C O'Donovan;Yan A Meng;Ian R Jones

  • Rare chromosomal deletions and duplications increase risk of schizophrenia

    Jennifer L. Stone;Jennifer L. Stone;Jennifer L. Stone;Michael C. O’Donovan;Hugh Gurling;George K. Kirov

  • Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders

    Phil H. Lee;Verneri Anttila;Hyejung Won;Yen-Chen A. Feng

  • Monte Carlo tests for associations between disease and alleles at highly polymorphic loci

    P. C. Sham;D. Curtis

  • Contribution of copy number variants to schizophrenia from a genome-wide study of 41,321 subjects

    Christian R Marshall;Daniel P Howrigan;Daniel P Howrigan;Daniele Merico;Bhooma Thiruvahindrapuram

  • Whole-genome association study of bipolar disorder

    P Sklar;J W Smoller;J Fan;J Fan;M A R Ferreira

  • An extended transmission/disequilibrium test (TDT) for multi-allele marker loci

    P. C. Sham;D. Curtis

  • Genomic Dissection of Bipolar Disorder and Schizophrenia, Including 28 Subphenotypes

    Douglas M. Ruderfer;Stephan Ripke;Stephan Ripke;Stephan Ripke;Andrew McQuillin;James Boocock

  • Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways

    Colm O'Dushlaine;Lizzy Rossin;Phil H. Lee;Laramie Duncan;Laramie Duncan

  • Partitioning heritability of regulatory and cell-type-specific variants across 11 common diseases

    Alexander Gusev;S. Hong Lee;Gosia Trynka;Hilary Finucane

  • Genomewide Genetic Linkage Analysis Confirms the Presence of Susceptibility Loci for Schizophrenia, on Chromosomes 1q32.2, 5q33.2, and 8p21-22 and Provides Support for Linkage to Schizophrenia, on Chromosomes 11q23.3-24 and 20q12.1-11.23

    Hugh M.D. Gurling;Gursharan Kalsi;Jon Brynjolfson;Thordur Sigmundsson

  • Model-Free Analysis and Permutation Tests for Allelic Associations

    Jing Hua Zhao;David Curtis;Pak Chung Sham

  • The UK10K project identifies rare variants in health and disease

    Klaudia Walter;Josine L. Min;Jie Huang;Lucy Crooks

  • Genome wide meta-analysis identifies genomic relationships, novel loci, and pleiotropic mechanisms across eight psychiatric disorders

    Lee Ph;Anttila;Won H

Frequent Co-Authors

Andrew McQuillin
Andrew McQuillin University College London
Michael John Owen
Michael John Owen Cardiff University
Hugh Gurling
Hugh Gurling University College London
Stephan Ripke
Stephan Ripke Massachusetts General Hospital
Thomas Werge
Thomas Werge University of Copenhagen
Douglas Blackwood
Douglas Blackwood University of Edinburgh
Stefan Herms
Stefan Herms University of Basel
Patrick F. Sullivan
Patrick F. Sullivan University of North Carolina at Chapel Hill
Michael Conlon O'Donovan
Michael Conlon O'Donovan Cardiff University
Aarno Palotie
Aarno Palotie University of Helsinki

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