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Biology and Biochemistry

D-Index
81
Citations
23583
World Ranking
3900
National Ranking
1930

Overview

Shunichi Shimasaki is affiliated with the University of California, San Diego in the United States. Their research primarily spans the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with substantial focus on Molecular Biology, Cancer Research, Pathology and Forensic Medicine, Reproductive Medicine, and Genetics.

The main topics addressed in Shimasaki's work include:

  • FOXO transcription factor regulation
  • Cancer-related molecular mechanisms research
  • Cancer Mechanisms and Therapy
  • Ovarian function and disorders
  • Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
  • Sexual Differentiation and Disorders
  • Methemoglobinemia and Tumor Lysis Syndrome

Among Shimasaki's recent publications are the following papers:

  • "FOXO1 mitigates the SMAD3/FOXL2C134W transcriptomic effect in a model of human adult granulosa cell tumor," 2021, Journal of Translational Medicine
  • "Effect of the spatial-temporal specific theca cell Cyp17 overexpression on the reproductive phenotype of the novel TC17 mouse," 2021, Journal of Translational Medicine
  • "Successful Management of Tumor Lysis Syndrome Following Enfortumab Vedotin Plus Pembrolizumab Therapy in Metastatic Urothelial Carcinoma: A Case Report," 2025, IJU Case Reports
  • "FOXO1 Mitigation of FOXL2C143W/SMAD3 Transcriptomic Landscape in a Model of Granulosa Cell Tumor," 2021, Journal of the Endocrine Society
  • "FOXO1 mitigates the SMAD3/FOXL2C134WTranscriptomic Effect in a Model of Human Adult Granulosa Cell Tumor," 2020, bioRxiv (Cold Spring Harbor Laboratory)

Shimasaki's work has been published frequently in the following venues:

  • Journal of Translational Medicine
  • IJU Case Reports
  • Journal of the Endocrine Society
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Journal of Robotic Surgery

Frequent collaborators in Shimasaki's research include Christian Secchi, Martina Belli, Dwayne G. Stupack, Paola Benaglio, and Francesca Mulas.

Best Publications

  • Pituitary FSH Is Released by a Heterodimer of the β-Subunits from the Two Forms of Inhibin

    Nicholas Ling;Shao-Yao Ying;Naoto Ueno;Shunichi Shimasaki

  • The bone morphogenetic protein system in mammalian reproduction

    Shunichi Shimasaki;R. Kelly Moore;Fumio Otsuka;Gregory F. Erickson

  • Identification and molecular characterization of insulin-like growth factor binding proteins (IGFBP-1, -2, -3, -4, -5 and -6).

    Shunichi Shimasaki;Nicholas Ling

  • Isolation and partial characterization of follistatin: a single-chain Mr 35,000 monomeric protein that inhibits the release of follicle-stimulating hormone.

    Naoto Ueno;Nicholas Ling;Shao-Yao Ying;Frederick Esch

  • Bone Morphogenetic Protein-15 IDENTIFICATION OF TARGET CELLS AND BIOLOGICAL FUNCTIONS

    Fumio Otsuka;Zuxu Yao;Taek Hoo Lee;Shin Yamamoto

  • Direct binding of follistatin to a complex of bone-morphogenetic protein and its receptor inhibits ventral and epidermal cell fates in early Xenopus embryo

    Shun Ichiro Iemura;Takamasa S. Yamamoto;Chiyo Takagi;Hideho Uchiyama

  • Molecular Basis of Bone Morphogenetic Protein-15 Signaling in Granulosa Cells *

    R. Kelly Moore;Fumio Otsuka;Shunichi Shimasaki

  • Identification of five different insulin-like growth factor binding proteins (IGFBPs) from adult rat serum and molecular cloning of a novel IGFBP-5 in rat and human.

    S Shimasaki;M Shimonaka;H P Zhang;N Ling

  • A functional bone morphogenetic protein system in the ovary

    S. Shimasaki;R. J. Zachow;Danmei Li;H. Kim

  • Integral role of GDF-9 and BMP-15 in ovarian function.

    Fumio Otsuka;Kirsten J. McTavish;Shunichi Shimasaki

  • Bone morphogenetic protein-15 inhibits follicle-stimulating hormone (FSH) action by suppressing FSH receptor expression.

    Fumio Otsuka;Shin Yamamoto;Gregory F. Erickson;Shunichi Shimasaki

  • The spatiotemporal expression pattern of the bone morphogenetic protein family in rat ovary cell types during the estrous cycle

    Gregory F Erickson;Shunichi Shimasaki

  • FOLLISTATIN BINDS TO BOTH ACTIVIN AND INHIBIN THROUGH THE COMMON BETA-SUBUNIT

    Motoyuki Shimonaka;Satoshi Inouye;Shunichi Shimasaki;Nicholas Ling

  • Molecular cloning of the cDNAs encoding a novel insulin-like growth factor-binding protein from rat and human.

    Shunichi Shimasaki;Fumiaki Uchiyama;Motoyuki Shimonaka;Nicholas Ling

  • Effect of Bone Morphogenetic Protein-7 on Folliculogenesis and Ovulation in the Rat

    W S Lee;F Otsuka;R K Moore;S Shimasaki

  • A negative feedback system between oocyte bone morphogenetic protein 15 and granulosa cell kit ligand: its role in regulating granulosa cell mitosis.

    Fumio Otsuka;Shunichi Shimasaki

  • OOCYTE-DERIVED BMP15 AND FGFS COOPERATE TO PROMOTE GLYCOLYSIS IN CUMULUS CELLS

    Koji Sugiura;You Qiang Su;Francisco J. Diaz;Stephanie A. Pangas

  • Isolation and molecular cloning of insulin-like growth factor-binding protein-6.

    Shunichi Shimasaki;Lin Gao;Motoyuki Shimonaka;Nicholas Ling

  • Complementary Deoxyribonucleic Acid (cDNA) Cloning and DNA Sequence Analysis of Rat Ovarian Inhibins

    F. S. Esch;S. Shimasaki;K. Cooksey;M. Mercado

  • Basic Fibroblast Growth Factor (FGF) in the Central Nervous System: Identification of Specific Loci of Basic FGF Expression in the Rat Brain

    Naoya Emoto;Ana-Maria Gonzalez;Patricia A. Walicke;Etsuko Wada

Frequent Co-Authors

Nicholas Ling
Nicholas Ling Salk Institute for Biological Studies
Frederick Esch
Frederick Esch Salk Institute for Biological Studies
Naoto Ueno
Naoto Ueno National Institute for Basic Biology
Roger Guillemin
Roger Guillemin Salk Institute for Biological Studies
Satoshi Inouye
Satoshi Inouye JNC (Japan)
Dwayne G. Stupack
Dwayne G. Stupack University of California, San Diego
Andrew Baird
Andrew Baird University of California, San Diego
Jorma Toppari
Jorma Toppari University of Turku
Philippa T. K. Saunders
Philippa T. K. Saunders University of Edinburgh
Yutaka Osuga
Yutaka Osuga University of Tokyo

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