Bernard Pirotte

Overview

Best Publications

• New Trends in Dual 5-LOX / COX Inhibition

  Xavier de Leval;Fabien Julemont;Jacques Delarge;Bernard Pirotte

  143
  Citations

• Study of the Influence of Both Cyclodextrins and L-Lysine on the Aqueous Solubility of Nimesulide; Isolation and Characterization of Nimesulide–L-Lysine–Cyclodextrin Complexes

  Géraldine Piel;Bernard Pirotte;Isabelle Delneuville;Philippe Neven

  132
  Citations

• New developments on thromboxane and prostacyclin modulators part I: thromboxane modulators.

  Jean-Michel Dogne;Xavier de Leval;Julien Hanson;Michel Frederich

  117
  Citations

• 3-(Alkylamino)-4h-Pyrido[4,3-E]-1,2,4-Thiadiazine 1,1-Dioxides as Powerful Inhibitors of Insulin Release from Rat Pancreatic B-Cells: A New Class of Potassium Channel Openers?

  Bernard Pirotte;Pascal de Tullio;Philippe Lebrun;Marie Helene Antoine

  113
  Citations

• Design, Synthesis, and Pharmacology of Novel 7-Substituted 3,4-Dihydro-2H-1,2,4-benzothiadiazine 1,1-Dioxides as Positive Allosteric Modulators of AMPA Receptors†

  Pierre Francotte;Pascal de Tullio;Eric Goffin;Gaëlle Dintilhac

  107
  Citations

• Esters and Amides of 6-(Chloromethyl)-2-oxo-2<i>H</i>-1-benzopyran-3-carboxylic Acid as Inhibitors of α-Chymotrypsin: Significance of the “Aromatic” Nature of the Novel Ester-Type Coumarin for Strong Inhibitory Activity

  Unknown

  98
  Citations

• Recent advances in inducible cyclooxygenase (COX-2) inhibition

  Xavier de Leval;Jacques Delarge;Fabian Somers;Pascal de Tullio

  92
  Citations

• 4H-1,2,4-Pyridothiadiazine 1,1-Dioxides and 2,3-Dihydro-4H-1,2,4-pyridothiadiazine 1,1-Dioxides Chemically Related to Diazoxide and Cyclothiazide as Powerful Positive Allosteric Modulators of (R/S)-2-Amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic Acid Receptors: Design, Synthesis, Pharmacology, and Structure−Activity Relationships

  Bernard Pirotte;Tchao Podona;Ousmane Diouf;Pascal de Tullio

  88
  Citations

• 3- and 4-substituted 4H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxides as potassium channel openers: synthesis, pharmacological evaluation and structure-activity relationships

  Pascal de Tullio;Bernard Pirotte;Philippe Lebrun;Jeanine Fontaine

  87
  Citations

• Toward Tissue-Selective Pancreatic B-Cells KATP Channel Openers Belonging to 3-Alkylamino-7-halo-4H-1,2,4-benzothiadiazine 1,1-Dioxides

  Pascal de Tullio;Bénédicte Becker;Stéphane Boverie;Michael Dabrowski

  84
  Citations

• New fluorinated 1,2,4-benzothiadiazine 1,1-dioxides: discovery of an orally active cognitive enhancer acting through potentiation of the 2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic acid receptors.

  Pierre Francotte;Eric Goffin;Pierre Fraikin;Pierre Lestage

  82
  Citations

• 3,6-disubstituted coumarins as mechanism-based inhibitors of thrombin and factor Xa.

  Raphaël Frédérick;Séverine Robert;Caroline Charlier;Jérôme de Ruyck

  79
  Citations

• Effect on K(ATP) channel activation properties and tissue selectivity of the nature of the substituent in the 7- and the 3-position of 4H-1,2,4-benzothiadiazine 1,1-dioxides.

  Stéphane Boverie;Marie-Hélène Antoine;Fabian Somers;Bénédicte Becker

  74
  Citations

• Metabolomics as a Challenging Approach for Medicinal Chemistry and Personalized Medicine.

  Michel Frédérich;Bernard Pirotte;Marianne Fillet;Pascal de Tullio

  74
  Citations

• Is thrombin generation the new rapid, reliable and relevant pharmacological tool for the development of anticoagulant drugs?

  Séverine Robert;Jérémie Ghiotto;Bernard Pirotte;Jean-Louis David

  73
  Citations

• Ligand effects in the hydrogenation of methacycline to doxycycline and epi-doxycycline catalysed by rhodium complexes molecular structure of the key catalyst [closo-3,3-(η2,3-C7H7CH2)-3,1,2-RhC2B9H11]

  Apostolos Felekidis;M. Goblet-Stachow;Jean-François Liégeois;Bernard Pirotte

  73
  Citations

• Toward the first class of suicide inhibitors of kallikreins involved in skin diseases.

  Xiao Tan;Feryel Soualmia;Feryel Soualmia;Laetitia Furio;Jean-François Renard

  73
  Citations

• New trends in the design of drugs against Alzheimer's disease.

  P. Francotte;E. Graindorge;S. Boverie;P. de Tullio

  68
  Citations

• Design, synthesis, and pharmacological evaluation of pyridinic analogues of nimesulide as cyclooxygenase-2 selective inhibitors.

  Fabien Julémont;Xavier de Leval;Catherine Michaux;Jean-François Renard

  67
  Citations

• 6-Substituted 2-oxo-2H-1-benzopyran-3-carboxylic acid derivatives in a new approach of the treatment of cancer cell invasion and metastasis

  Isabelle Kempen;Marc Hemmer;Stéphane Counerotte;Lionel Pochet

  64
  Citations

• BPDZ 154 activates adenosine 5'-triphosphate-sensitive potassium channels: in vitro studies using rodent insulin-secreting cells and islets isolated from patients with hyperinsulinism.

  Karen E. Cosgrove;Marie Hélène Antoine;Anne T. Lee;Philippa D. Barnes

  63
  Citations

• 3-Alkylamino-4H-pyrido[2,3-e]-1,2,4-thiadiazine 1,1-dioxides structurally related to diazoxide and pinacidil as potassium channel openers acting on vascular smooth muscle cells: design, synthesis, and pharmacological evaluation.

  Bernard Pirotte;Raogo Ouedraogo;Pascal de Tullio;Smail Khelili

  61
  Citations