World's Best Scientists 2026 revealed!
Molecular Systems Biology
H-index 53

Molecular Systems Biology

Ranking & Metrics

Discipline name Position Best Scientists Publications D-Index
Molecular Biology 33 57 62 28
Biology and Biochemistry 92 145 153 43

Additional Metrics

Number of Best Scientists*: 375
Documents by Best Scientists*: 266
Top 100 Ranked Scientists*: 21
SCIMAGO H-index: 178
SCIMAGO SJR: 4.783
Impact Factor: 7.7

Overview

Top Research Topics at Molecular Systems Biology?

The aim of the journal is to expand the discussion of research in Genetics, Computational biology, Cell biology, Gene and Systems biology. It primarily discusses Genetics topics, particularly Regulation of gene expression, Gene regulatory network, Gene expression, Genome and Transcription factor. The work on Regulation of gene expression addressed in it expands to the thematically related Transcriptional regulation.

It facilitates discussions on Computational biology that incorporate concepts from other fields like Transcriptome, Proteomics, Bioinformatics and Protein–protein interaction. Proteomics study tackled is connected to the field of Proteome. Topics in Cell biology explored in the journal were investigated in conjunction with research in Cell cycle, Cell and Cellular differentiation.

As a part of Molecular Systems Biology, discussions in Gene involve topics like Gene expression profiling, Phenotype, Promoter, Transcription (biology) and Saccharomyces cerevisiae. Molecular Systems Biology explores studies in Saccharomyces cerevisiae as part of the wider topic of Biochemistry. The study on Systems biology presented in the journal intersects with the topics under Data science.

  • Genetics (35.81%)
  • Computational biology (27.91%)
  • Cell biology (27.03%)

What are the most cited papers published in the journal?

  • Fast, scalable generation of high‐quality protein multiple sequence alignments using Clustal Omega (8955 citations)
  • Construction of Escherichia coli K-12 in-frame, single-gene knockout mutants: the Keio collection. (5986 citations)
  • Network-based classification of breast cancer metastasis. (1293 citations)

Research areas of the most cited articles at Molecular Systems Biology:

The main points discussed in the journal publications deal with Genetics, Computational biology, Systems biology, Cell biology and Bioinformatics. The Computational biology research tackled in the journal articles is interrelated with Proteome which concerns subjects like Transcriptome. While the journal publications focused on Systems biology, they were also able to explore topics like Biological system, Biochemistry, Metabolic network and Robustness (evolution).

What topics the last edition of the journal is best known for?

  • Gene
  • Enzyme
  • DNA

The previous edition focused in particular on these issues:

Molecular Systems Biology is mainly concerned with subjects like Computational biology, Cell biology, Gene, Transcription factor and Gene expression. The studies in Computational biology featured incorporate elements of Amino acid, Proteome and Transcriptome. Cell biology research presented in the journal encompasses a variety of subjects, including Chromatin, Cell cycle, Phenotype and RNA splicing.

Molecular Systems Biology focuses on Phenotype research as part of the broader topic of Genetics. Most of the works presented in the journal deals with Gene but it intersects with the subject of Function (biology). Studies on Gene expression discussed in the journal link to the field of Regulation of gene expression.

The most cited articles from the last journal are:

  • Probabilistic harmonization and annotation of single-cell transcriptomics data with deep generative models. (28 citations)
  • Integrated intra- and intercellular signaling knowledge for multicellular omics analysis. (23 citations)
  • Single-cell analyses reveal SARS-CoV-2 interference with intrinsic immune response in the human gut. (18 citations)

Papers citation over time

A key indicator for each journal is its effectiveness in reaching other researchers with the papers published at that venue.

The chart below presents the interquartile range (first quartile 25%, median 50% and third quartile 75%) of the number of citations of articles over time.

The top authors publishing in Molecular Systems Biology (based on the number of publications) are:

  • Ruedi Aebersold (26 papers) published 2 papers at the last edition,
  • Peer Bork (21 papers) absent at the last edition,
  • Bernhard O. Palsson (20 papers) published 1 paper at the last edition the same number as at the previous edition,
  • Uwe Sauer (19 papers) published 1 paper at the last edition, 1 less than at the previous edition,
  • Jens Nielsen (18 papers) published 2 papers at the last edition, 1 more than at the previous edition.

The overall trend for top authors publishing in this journal is outlined below. The chart shows the number of publications at each edition of the journal for top authors.

Only papers with recognized affiliations are considered

The top affiliations publishing in Molecular Systems Biology (based on the number of publications) are:

  • Harvard University (106 papers) published 5 papers at the last edition, 1 more than at the previous edition,
  • ETH Zurich (67 papers) published 4 papers at the last edition, 3 less than at the previous edition,
  • European Bioinformatics Institute (65 papers) published 6 papers at the last edition the same number as at the previous edition,
  • Massachusetts Institute of Technology (61 papers) published 5 papers at the last edition, 1 less than at the previous edition,
  • Max Planck Society (56 papers) published 3 papers at the last edition, 5 less than at the previous edition.

The overall trend for top affiliations publishing in this journal is outlined below. The chart shows the number of publications at each edition of the journal for top affiliations.

Publication chance based on affiliation

The publication chance index shows the ratio of articles published by the best research institutions in the journal edition to all articles published within that journal. The best research institutions were selected based on the largest number of articles published during all editions of the journal.

The chart below presents the percentage ratio of articles from top institutions (based on their ranking of total papers).Top affiliations were grouped by their rank into the following tiers: top 1-10, top 11-20, top 21-50, and top 51+. Only articles with a recognized affiliation are considered.

During the most recent 2021 edition, 0.00% of publications had an unrecognized affiliation. Out of the publications with recognized affiliations, 39.19% were posted by at least one author from the top 10 institutions publishing in the journal. Another 17.57% included authors affiliated with research institutions from the top 11-20 affiliations. Institutions from the 21-50 range included 25.68% of all publications and 17.57% were from other institutions.

Returning Authors Index

A very common phenomenon observed among researchers publishing scientific articles is the intentional selection of journals they have already attended in the past. In particular, it is worth analyzing the case when the authors participate in the same journal from year to year.

The Returning Authors Index presented below illustrates the ratio of authors who participated in both a given as well as the previous edition of the journal in relation to all participants in a given year.

Returning Institution Index

The graph below shows the Returning Institution Index, illustrating the ratio of institutions that participated in both a given and the previous edition of the conference in relation to all affiliations present in a given year.

The experience to innovation index

Our experience to innovation index was created to show a cross-section of the experience level of authors publishing in a journal. The index includes the authors publishing at the last edition of a journal, grouped by total number of publications throughout their academic career (P) and the total number of citations of these publications ever received (C).

The group intervals were selected empirically to best show the diversity of the authors' experiences, their labels were selected as a convenience, not as judgment. The authors were divided into the following groups:

  • Novice - P < 5 or C < 25 (the number of publications less than 5 or the number of citations less than 25),
  • Competent - P < 10 or C < 100 (the number of publications less than 10 or the number of citations less than 100),
  • Experienced - P < 25 or C < 625 (the number of publications less than 25 or the number of citations less than 625),
  • Master - P < 50 or C < 2500 (the number of publications less than 50 or the number of citations less than 2500),
  • Star - P ≥ 50 and C ≥ 2500 (both the number of publications greater than 50 and the number of citations greater than 2500).

The chart below illustrates experience levels of first authors in cases of publications with multiple authors.

Top Publications

  • The protein expression profile of ACE2 in human tissues.

    Feria Hikmet;Loren Méar;Åsa Edvinsson;Patrick Micke

    (2020)
    1023 Citations
  • Ultra‐high sensitivity mass spectrometry quantifies single‐cell proteome changes upon perturbation

    (2020)
    674 Citations
  • Probabilistic harmonization and annotation of single-cell transcriptomics data with deep generative models.

    Chenling Xu;Romain Lopez;Edouard Mehlman;Edouard Mehlman;Jeffrey Regier

    (2021)
    372 Citations
  • Proteome profiling in cerebrospinal fluid reveals novel biomarkers of Alzheimer's disease

    Jakob M Bader;Philipp E Geyer;Philipp E Geyer;Johannes B Müller;Maximilian T Strauss

    (2020)
    295 Citations
  • SBML Level 3: an extensible format for the exchange and reuse of biological models

    Sarah M. Keating;Sarah M. Keating;Dagmar Waltemath;Matthias König;Fengkai Zhang

    (2020)
    283 Citations
  • Integrated intra- and intercellular signaling knowledge for multicellular omics analysis.

    Dénes Türei;Alberto Valdeolivas;Lejla Gul;Nicolàs Palacio-Escat;Nicolàs Palacio-Escat

    (2021)
    220 Citations
  • Benchmarking AlphaFold‐enabled molecular docking predictions for antibiotic discovery

    (2022)
    208 Citations
  • Automated sample preparation with SP3 for low-input clinical proteomics

    Torsten Müller;Torsten Müller;Mathias Kalxdorf;Mathias Kalxdorf;Rémi Longuespée;Daniel N Kazdal

    (2020)
    201 Citations
  • RNA velocity-current challenges and future perspectives.

    Volker Bergen;Ruslan A Soldatov;Peter V Kharchenko;Fabian J Theis

    (2021)
    197 Citations

Related Online Degrees & Career Pathways

For students pursuing Biology and Biochemistry, exploring related online degrees can broaden career prospects in healthcare and life sciences. Many professionals are turning to specialized online programs that offer affordability and flexibility. For those interested in healthcare, the cheapest psych np programs online provide an accessible path to becoming a psychiatric nurse practitioner, blending clinical expertise with mental health insights.

Fitness science enthusiasts might consider an exercise science online degree, which equips students with knowledge related to human physiology, performance, and rehabilitation. This is a natural extension for biology graduates aiming to work in wellness or physical therapy sectors.

Mental health remains a critical and growing field, making degrees in counseling particularly valuable. The cheapest online masters in mental health counseling offer a cost-effective way to enter this compassionate profession. Moreover, programs like the online masters degree in mental health counseling provide expedited options for those ready to advance quickly.

These pathways highlight the versatility of a Biology or Biochemistry foundation, supporting diverse careers from clinical practice to health science education.

Best Scientists Contributing to This Journal