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Laboratory Investigation
H-index 32

Laboratory Investigation

0023-6837

Published by: Nature

https://www.nature.com/labinvest/

Ranking & Metrics

Discipline name Position Best Scientists Publications D-Index
Biology and Biochemistry 261 129 133 23
Medicine 920 205 194 24

Additional Metrics

Number of Best Scientists*: 417
Documents by Best Scientists*: 338
Top 100 Ranked Scientists*: 7
SCIMAGO H-index: 170
SCIMAGO SJR: 1.254
Impact Factor: 4.2

Overview

Top Research Topics at Laboratory Investigation?

The main points discussed in Laboratory Investigation deals with Pathology, Internal medicine, Endocrinology, Molecular biology and Immunology. Issues in Pathology were discussed, taking into consideration concepts from other disciplines like Cancer research and Lung. The Internal medicine works featured in Laboratory Investigation incorporate elements from Cardiology and Cell biology.

Laboratory Investigation connects the study in Endocrinology with the closely related area of Receptor. Cell culture, Antibody and Antigen are some topics wherein Molecular biology research discussed in it have an impact. Immune system and Inflammation are all areas of Immunology tackled in Laboratory Investigation.

  • Pathology (32.50%)
  • Internal medicine (22.39%)
  • Endocrinology (19.34%)

What are the most cited papers published in the journal?

  • Biology of disease: free radicals and tissue injury. (2798 citations)
  • Clinicopathologic study of dextran sulfate sodium experimental murine colitis (1751 citations)
  • Kinetics of cellular proliferation after arterial injury. I. Smooth muscle growth in the absence of endothelium. (1378 citations)

Research areas of the most cited articles at Laboratory Investigation:

The most cited publications cover a variety of subjects, including Pathology, Internal medicine, Endocrinology, Cell biology and Immunology. While the primary focus in the journal publications is Pathology, they also dissect topics surrounding Molecular biology and Cell culture as a whole. In addition to Endocrinology research, the published papers aim to explore topics under Receptor and Growth factor.

What topics the last edition of the journal is best known for?

  • Internal medicine
  • Gene
  • Enzyme

The previous edition focused in particular on these issues:

The journal covers a variety of subjects, including Cancer research, Cell biology, Downregulation and upregulation, Virology and 2019-20 coronavirus outbreak. It facilitates discussions on Cancer research that incorporate concepts from other fields like Immunohistochemistry, Apoptosis, Gene knockdown, Cell growth and In vivo. The journal features research on Immunohistochemistry in an attempt to reinforce studies in the field of Pathology.

Topics in Apoptosis were tackled in line with various other fields like Flow cytometry and TXNIP. The journal addresses concerns in Cell biology which are intertwined with other disciplines, such as Cell migration, Viability assay, microRNA and Wound healing. The studies on 2019-20 coronavirus outbreak discussed can also contribute to research in the domains of Autopsy and Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Coronavirus disease 2019 (COVID-19).

The most cited articles from the last journal are:

  • Artificial intelligence and computational pathology. (11 citations)
  • Overexpression of pigment epithelium-derived factor in placenta-derived mesenchymal stem cells promotes mitochondrial biogenesis in retinal cells. (8 citations)
  • Establishing a living biobank of patient-derived organoids of intraductal papillary mucinous neoplasms of the pancreas (7 citations)

Papers citation over time

A key indicator for each journal is its effectiveness in reaching other researchers with the papers published at that venue.

The chart below presents the interquartile range (first quartile 25%, median 50% and third quartile 75%) of the number of citations of articles over time.

The top authors publishing in Laboratory Investigation (based on the number of publications) are:

  • Ann M. Dvorak (32 papers) absent at the last edition,
  • George F. Murphy (29 papers) published 1 paper at the last edition the same number as at the previous edition,
  • David L. Rimm (25 papers) absent at the last edition,
  • Alfred F. Michael (23 papers) absent at the last edition,
  • Ismo Virtanen (22 papers) absent at the last edition.

The overall trend for top authors publishing in this journal is outlined below. The chart shows the number of publications at each edition of the journal for top authors.

Only papers with recognized affiliations are considered

The top affiliations publishing in Laboratory Investigation (based on the number of publications) are:

  • National Institutes of Health (158 papers) published 1 paper at the last edition, 1 less than at the previous edition,
  • Harvard University (119 papers) published 2 papers at the last edition the same number as at the previous edition,
  • French Institute of Health and Medical Research (101 papers) published 4 papers at the last edition,
  • University of Michigan (96 papers) published 1 paper at the last edition,
  • Yale University (81 papers) absent at the last edition.

The overall trend for top affiliations publishing in this journal is outlined below. The chart shows the number of publications at each edition of the journal for top affiliations.

Publication chance based on affiliation

The publication chance index shows the ratio of articles published by the best research institutions in the journal edition to all articles published within that journal. The best research institutions were selected based on the largest number of articles published during all editions of the journal.

The chart below presents the percentage ratio of articles from top institutions (based on their ranking of total papers).Top affiliations were grouped by their rank into the following tiers: top 1-10, top 11-20, top 21-50, and top 51+. Only articles with a recognized affiliation are considered.

During the most recent 2021 edition, 13.37% of publications had an unrecognized affiliation. Out of the publications with recognized affiliations, 10.07% were posted by at least one author from the top 10 institutions publishing in the journal. Another 12.08% included authors affiliated with research institutions from the top 11-20 affiliations. Institutions from the 21-50 range included 18.12% of all publications and 59.73% were from other institutions.

Returning Authors Index

A very common phenomenon observed among researchers publishing scientific articles is the intentional selection of journals they have already attended in the past. In particular, it is worth analyzing the case when the authors participate in the same journal from year to year.

The Returning Authors Index presented below illustrates the ratio of authors who participated in both a given as well as the previous edition of the journal in relation to all participants in a given year.

Returning Institution Index

The graph below shows the Returning Institution Index, illustrating the ratio of institutions that participated in both a given and the previous edition of the conference in relation to all affiliations present in a given year.

The experience to innovation index

Our experience to innovation index was created to show a cross-section of the experience level of authors publishing in a journal. The index includes the authors publishing at the last edition of a journal, grouped by total number of publications throughout their academic career (P) and the total number of citations of these publications ever received (C).

The group intervals were selected empirically to best show the diversity of the authors' experiences, their labels were selected as a convenience, not as judgment. The authors were divided into the following groups:

  • Novice - P < 5 or C < 25 (the number of publications less than 5 or the number of citations less than 25),
  • Competent - P < 10 or C < 100 (the number of publications less than 10 or the number of citations less than 100),
  • Experienced - P < 25 or C < 625 (the number of publications less than 25 or the number of citations less than 625),
  • Master - P < 50 or C < 2500 (the number of publications less than 50 or the number of citations less than 2500),
  • Star - P ≥ 50 and C ≥ 2500 (both the number of publications greater than 50 and the number of citations greater than 2500).

The chart below illustrates experience levels of first authors in cases of publications with multiple authors.

Career Prospects in Research

While exploring various research disciplines and their developments, it is fascinating to understand how this can be applied to a professional context. For instance, aspiring researchers in the field of nutritional sciences can look at the groundbreaking studies in this field and develop a clear career path. If you are interested in becoming a nutritionist and looking for career guidance, you can check out this guide on how to become a nutritionist in Virginia. The guide provides a comprehensive roadmap on the required educational qualifications, practical training, and necessary certifications for the role. Venturing into research careers can also involve an in-depth understanding and application of topics under Pathology, Internal medicine, and Endocrinology etc., as these are significant research topics in Laboratory Investigation. Undoubtedly, the career prospects in research are plentiful and wide-ranging, whether it's in basic sciences or inter-disciplinary fields such as molecular biology. It's about finding your area of interest and progressing in your path with continuous learning and investigation.

Top Publications

  • CCL8 secreted by tumor-associated macrophages promotes invasion and stemness of glioblastoma cells via ERK1/2 signaling.

    Xiang Zhang;Lu Chen;Wei-qi Dang;Mian-fu Cao

    (2020)
    121 Citations
  • Advancements in detection of SARS-CoV-2 infection for confronting COVID-19 pandemics.

    Yuan Zhou;Li Zhang;You-Hua Xie;Jian Wu;Jian Wu

    (2021)
    62 Citations
  • Quantitative assessment of PD-L1 as an analyte in immunohistochemistry diagnostic assays using a standardized cell line tissue microarray.

    Sandra Martinez-Morilla;John McGuire;Patricia Gaule;Lauren Moore

    (2020)
    60 Citations
  • Deep learning shows the capability of high-level computer-aided diagnosis in malignant lymphoma.

    Hiroaki Miyoshi;Kensaku Sato;Yoshinori Kabeya;Sho Yonezawa

    (2020)
    60 Citations
  • Characterization of COVID-19-associated cardiac injury: evidence for a multifactorial disease in an autopsy cohort

    (2022)
    58 Citations
  • CCL3-CCR5 axis contributes to progression of esophageal squamous cell carcinoma by promoting cell migration and invasion via Akt and ERK pathways.

    Takayuki Kodama;Yu-Ichiro Koma;Noriaki Arai;Aya Kido;Aya Kido

    (2020)
    55 Citations
  • PAI-1 derived from cancer-associated fibroblasts in esophageal squamous cell carcinoma promotes the invasion of cancer cells and the migration of macrophages.

    Hiroki Sakamoto;Yu-Ichiro Koma;Nobuhide Higashino;Takayuki Kodama

    (2021)
    50 Citations
  • CircRNA-ST6GALNAC6 increases the sensitivity of bladder cancer cells to erastin-induced ferroptosis by regulating the HSPB1/P38 axis

    (2022)
    49 Citations
  • Standardized Pathology Screening of Mature Tertiary Lymphoid Structures in Cancers.

    (2023)
    46 Citations

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