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Drug Metabolism and Disposition
H-index 28

Drug Metabolism and Disposition

0090-9556

Published by: American Society for Pharmacology and Experimental Therapeutics

https://dmd.aspetjournals.org/

Ranking & Metrics

Discipline name Position Best Scientists Publications D-Index
Medicine 1021 56 109 23

Additional Metrics

Number of Best Scientists*: 188
Documents by Best Scientists*: 292
Top 100 Ranked Scientists*: 5
SCIMAGO H-index: 198
SCIMAGO SJR: 1.245
Impact Factor: 4

Overview

Top Research Topics at Drug Metabolism and Disposition?

The topics of Pharmacology, Biochemistry, Metabolite, Pharmacokinetics and Metabolism are the focal point of discussions in Drug Metabolism and Disposition. The study of Pharmacology encompasses disciplines such as In vivo, as well as fields such as Hepatocyte, all of which overlap with one another. It primarily discusses Biochemistry topics, particularly Microsome, Cytochrome P450, Enzyme, In vitro and Glucuronidation.

The research on Microsome tackled can also make contributions to studies in the areas of Phenobarbital, Cytochrome, Enzyme inhibitor and Hydroxylation. In addition to Cytochrome P450 research, it aims to explore topics under Molecular biology and Isozyme. Topics in Metabolite explored in it were investigated in conjunction with research in Urine, Glutathione, Stereochemistry and Chromatography.

The studies in Urine featured incorporate elements of Urinary system and Feces. The journal facilitates discussions on Pharmacokinetics that incorporate concepts from other fields like Oral administration, Endocrinology, Excretion and Bioavailability. Metabolism and Biotransformation are closely related fields of research discussed in it.

  • Pharmacology (35.58%)
  • Biochemistry (33.90%)
  • Metabolite (28.10%)

What are the most cited papers published in the journal?

  • ETHOXYRESORUFIN: DIRECT FLUORIMETRIC ASSAY OF A MICROSOMAL O-DEALKYLATION WHICH IS PREFERENTIALLY INDUCIBLE BY 3-METHYLCHOLANTHRENE (1500 citations)
  • HIGH ABSORPTION BUT VERY LOW BIOAVAILABILITY OF ORAL RESVERATROL IN HUMANS (1293 citations)
  • Prediction of human clearance of twenty-nine drugs from hepatic microsomal intrinsic clearance data: An examination of in vitro half-life approach and nonspecific binding to microsomes. (1012 citations)

Research areas of the most cited articles at Drug Metabolism and Disposition:

The journal publications explore disciplines such as Pharmacology, Biochemistry, Microsome, Cytochrome P450 and Metabolite. While the primary focus in the most cited publications is Pharmacology, they also dissect topics surrounding In vivo and In vitro and Hepatocyte as a whole. While the published papers focused on Metabolite, they were also able to explore topics like Chromatography and Glutathione.

What topics the last edition of the journal is best known for?

  • Enzyme
  • Internal medicine
  • Gene

The previous edition focused in particular on these issues:

The journal focuses largely on the fields of Pharmacology, Pharmacokinetics, Drug metabolism, In vivo and Cytochrome P450. The studies on Pharmacology discussed can also contribute to research in the domains of CYP3A4, CYP3A, Transporter and Metabolite. The work on Metabolite tackled in it brings together disciplines like Oral administration and Ex vivo.

The research on Pharmacokinetics featured in the journal combines topics in other fields like Biophysics and Distribution (pharmacology). Studies in Biochemistry and Enzyme serves as the foundation for the Cytochrome P450 research presented. Studies on Metabolism tackled in Drug Metabolism and Disposition are critical in grasping new concepts in the fields of Endocrinology and Internal medicine.

The most cited articles from the last journal are:

  • Impact of plasma protein binding in drug clearance prediction: a database analysis of published studies and implications for in vitro in vivo extrapolation (6 citations)
  • Effect of Human Plasma on Hepatic Uptake of Organic Anion-Transporting Polypeptide 1B Substrates: Studies Using Transfected Cells and Primary Human Hepatocytes. (5 citations)
  • Disposition and Metabolism of [14C]Lemborexant in Healthy Human Subjects and Characterization of Its Circulating Metabolites (5 citations)

Papers citation over time

A key indicator for each journal is its effectiveness in reaching other researchers with the papers published at that venue.

The chart below presents the interquartile range (first quartile 25%, median 50% and third quartile 75%) of the number of citations of articles over time.

The top authors publishing in Drug Metabolism and Disposition (based on the number of publications) are:

  • Yuichi Sugiyama (97 papers) published 1 paper at the last edition,
  • Curtis D. Klaassen (75 papers) published 2 papers at the last edition,
  • Miki Nakajima (70 papers) published 2 papers at the last edition,
  • R. Scott Obach (65 papers) published 3 papers at the last edition,
  • Tsuyoshi Yokoi (63 papers) absent at the last edition.

The overall trend for top authors publishing in this journal is outlined below. The chart shows the number of publications at each edition of the journal for top authors.

Only papers with recognized affiliations are considered

The top affiliations publishing in Drug Metabolism and Disposition (based on the number of publications) are:

  • Pfizer (321 papers) published 6 papers at the last edition, 3 more than at the previous edition,
  • University of Washington (285 papers) published 11 papers at the last edition, 5 more than at the previous edition,
  • Merck & Co. (189 papers) published 4 papers at the last edition, 3 more than at the previous edition,
  • National Institutes of Health (153 papers) published 2 papers at the last edition the same number as at the previous edition,
  • Bristol-Myers Squibb (136 papers) published 3 papers at the last edition the same number as at the previous edition.

The overall trend for top affiliations publishing in this journal is outlined below. The chart shows the number of publications at each edition of the journal for top affiliations.

Publication chance based on affiliation

The publication chance index shows the ratio of articles published by the best research institutions in the journal edition to all articles published within that journal. The best research institutions were selected based on the largest number of articles published during all editions of the journal.

The chart below presents the percentage ratio of articles from top institutions (based on their ranking of total papers).Top affiliations were grouped by their rank into the following tiers: top 1-10, top 11-20, top 21-50, and top 51+. Only articles with a recognized affiliation are considered.

During the most recent 2021 edition, 3.20% of publications had an unrecognized affiliation. Out of the publications with recognized affiliations, 32.23% were posted by at least one author from the top 10 institutions publishing in the journal. Another 13.22% included authors affiliated with research institutions from the top 11-20 affiliations. Institutions from the 21-50 range included 19.83% of all publications and 34.71% were from other institutions.

Returning Authors Index

A very common phenomenon observed among researchers publishing scientific articles is the intentional selection of journals they have already attended in the past. In particular, it is worth analyzing the case when the authors participate in the same journal from year to year.

The Returning Authors Index presented below illustrates the ratio of authors who participated in both a given as well as the previous edition of the journal in relation to all participants in a given year.

Returning Institution Index

The graph below shows the Returning Institution Index, illustrating the ratio of institutions that participated in both a given and the previous edition of the conference in relation to all affiliations present in a given year.

The experience to innovation index

Our experience to innovation index was created to show a cross-section of the experience level of authors publishing in a journal. The index includes the authors publishing at the last edition of a journal, grouped by total number of publications throughout their academic career (P) and the total number of citations of these publications ever received (C).

The group intervals were selected empirically to best show the diversity of the authors' experiences, their labels were selected as a convenience, not as judgment. The authors were divided into the following groups:

  • Novice - P < 5 or C < 25 (the number of publications less than 5 or the number of citations less than 25),
  • Competent - P < 10 or C < 100 (the number of publications less than 10 or the number of citations less than 100),
  • Experienced - P < 25 or C < 625 (the number of publications less than 25 or the number of citations less than 625),
  • Master - P < 50 or C < 2500 (the number of publications less than 50 or the number of citations less than 2500),
  • Star - P ≥ 50 and C ≥ 2500 (both the number of publications greater than 50 and the number of citations greater than 2500).

The chart below illustrates experience levels of first authors in cases of publications with multiple authors.

Top Publications

  • Quantitative Proteomics of Clinically Relevant Drug-Metabolizing Enzymes and Drug Transporters and Their Intercorrelations in the Human Small Intestine.

    Narciso Couto;Zubida Al-Majdoub;Stephanie L Gibson;Pamela J Davies

    (2020)
    81 Citations
  • Emerging Roles of the Human Solute Carrier 22 Family

    (2021)
    75 Citations
  • Quantitative Investigation of Irinotecan Metabolism, Transport, and Gut Microbiome Activation.

    Masud Parvez;Abdul Basit;Parth B. Jariwala;Zsuzsanna Gáborik

    (2021)
    48 Citations
  • Absorption, Metabolism, and Excretion, In Vitro Pharmacology, and Clinical Pharmacokinetics of Ozanimod, a Novel Sphingosine 1-Phosphate Receptor Modulator

    (2021)
    44 Citations
  • Comparative Hepatic and Intestinal Efflux Transport of Statins.

    Feng Deng;Suvi-Kukka Tuomi;Mikko Neuvonen;Päivi Hirvensalo

    (2021)
    40 Citations
  • Impact of Plasma Protein Binding in Drug Clearance Prediction: A Data Base Analysis of Published Studies and Implications for In Vitro-In Vivo Extrapolation

    (2020)
    40 Citations
  • Abundant Expression of OCT2, MATE1, OAT1, OAT3, PEPT2, BCRP, MDR1, and xCT Transporters in Blood-Arachnoid Barrier of Pig and Polarized Localizations at CSF- and Blood-Facing Plasma Membranes

    Yasuo Uchida;Ryohei Goto;Hina Takeuchi;Magdalena Łuczak

    (2020)
    37 Citations
  • Usefulness of Human Jejunal Spheroid–Derived Differentiated Intestinal Epithelial Cells for the Prediction of Intestinal Drug Absorption in Humans

    (2022)
    37 Citations
  • MOLECULAR REGULATION OF BILE ACID HOMEOSTASIS

    Supratim Choudhuri;Curtis D Klaassen

    (2021)
    36 Citations

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Best Scientists Contributing to This Journal