Altex

Top Research Topics at ALTEX-Alternatives to Animal Experimentation?

The topics of In vitro, In vivo, Pharmacology, Animal testing and Risk analysis (engineering) are the focal point of discussions in the journal. Cell culture and Immunology are some topics wherein In vitro research discussed in the journal have an impact. The Cell culture study featured in it draws parallels with the field of Cell biology.

The Pharmacology study featured in ALTEX-Alternatives to Animal Experimentation draws connections with the study of Toxicity. The study on Risk analysis (engineering) presented in ALTEX-Alternatives to Animal Experimentation intersects with subjects under the field of Risk assessment.

• In vitro (12.66%)
• In vivo (10.42%)
• Pharmacology (9.65%)

What are the most cited papers published in the journal?

• The suitability of BV2 cells as alternative model system for primary microglia cultures or for animal experiments examining brain inflammation. (459 citations)
• DarT: The embryo test with the Zebrafish Danio rerio--a general model in ecotoxicology and toxicology. (399 citations)
• Towards an alternative for the acute fish LC(50) test in chemical assessment: the fish embryo toxicity test goes multi-species -- an update. (301 citations)

Research areas of the most cited articles at ALTEX-Alternatives to Animal Experimentation:

The most cited publications primarily tackle Risk analysis (engineering), Toxicology, Cell culture, Test (assessment) and Biotechnology. The published papers hold forums on Risk analysis (engineering) that merge themes from other disciplines such as Paradigm shift, Process (engineering) and Risk assessment. The most cited papers tackle studies in Immunology and the interrelated subject of In vivo to gain insights into Cell culture.

What topics the last edition of the journal is best known for?

• Internal medicine
• Law
• Gene

The previous edition focused in particular on these issues:

ALTEX-Alternatives to Animal Experimentation tackles a plethora of topics, such as Risk analysis (engineering), Risk assessment, Alternative methods, Pharmacology and In vivo. Risk analysis (engineering) research featured in ALTEX-Alternatives to Animal Experimentation incorporates concerns from various other topics such as Cosmetics, Certification, Method development, Computational model and Variety (cybernetics). ALTEX-Alternatives to Animal Experimentation addresses concerns in Risk assessment which are intertwined with other disciplines, such as Range (statistics), Rank score, Statistics and Process (engineering).

The research on Pharmacology tackled can also make contributions to studies in the areas of In vitro, QTC PROLONGATION and Cardiotoxicity. ALTEX-Alternatives to Animal Experimentation features works in In vitro, more specifically In vitro toxicology, and explores their relation to disciplines like Positive control. Some problems in In vivo that were presented in the journal overlapped with concepts under Absorption (skin), Gene expression, Cell type and Metabolite.

The most cited articles from the last journal are:

• Pyrogen testing revisited on occasion of the 25th anniversary of the whole blood monocyte activation test. (3 citations)
• Applying evidence-based methods to the development and use of adverse outcome pathways (2 citations)
• Characteristics to consider when selecting a positive control material for an in vitro assay (2 citations)

Papers citation over time

A key indicator for each journal is its effectiveness in reaching other researchers with the papers published at that venue.

The chart below presents the interquartile range (first quartile 25%, median 50% and third quartile 75%) of the number of citations of articles over time.

Top authors and change over time

The top authors publishing in ALTEX-Alternatives to Animal Experimentation (based on the number of publications) are:

• Thomas Hartung (138 papers) published 6 papers at the last edition, 3 less than at the previous edition,
• Marcel Leist (67 papers) published 2 papers at the last edition, 8 less than at the previous edition,
• Horst Spielmann (33 papers) absent at the last edition,
• Mardas Daneshian (32 papers) absent at the last edition,
• Francesca Caloni (28 papers) published 3 papers at the last edition, 2 less than at the previous edition.

The overall trend for top authors publishing in this journal is outlined below. The chart shows the number of publications at each edition of the journal for top authors.

Top affiliations and change over time

Only papers with recognized affiliations are considered

The top affiliations publishing in ALTEX-Alternatives to Animal Experimentation (based on the number of publications) are:

• University of Konstanz (127 papers) published 6 papers at the last edition, 10 less than at the previous edition,
• Johns Hopkins University (119 papers) published 8 papers at the last edition, 1 less than at the previous edition,
• Paul Ehrlich Institute (40 papers) absent at the last edition,
• United States Environmental Protection Agency (38 papers) published 4 papers at the last edition, 3 more than at the previous edition,
• University of Milan (36 papers) published 3 papers at the last edition, 2 less than at the previous edition.

The overall trend for top affiliations publishing in this journal is outlined below. The chart shows the number of publications at each edition of the journal for top affiliations.

Publication chance based on affiliation

The publication chance index shows the ratio of articles published by the best research institutions in the journal edition to all articles published within that journal. The best research institutions were selected based on the largest number of articles published during all editions of the journal.

The chart below presents the percentage ratio of articles from top institutions (based on their ranking of total papers).Top affiliations were grouped by their rank into the following tiers: top 1-10, top 11-20, top 21-50, and top 51+. Only articles with a recognized affiliation are considered.

During the most recent 2021 edition, 20.00% of publications had an unrecognized affiliation. Out of the publications with recognized affiliations, 50.00% were posted by at least one author from the top 10 institutions publishing in the journal. Another 8.33% included authors affiliated with research institutions from the top 11-20 affiliations. Institutions from the 21-50 range included 13.89% of all publications and 27.78% were from other institutions.

Returning Authors Index

A very common phenomenon observed among researchers publishing scientific articles is the intentional selection of journals they have already attended in the past. In particular, it is worth analyzing the case when the authors participate in the same journal from year to year.

The Returning Authors Index presented below illustrates the ratio of authors who participated in both a given as well as the previous edition of the journal in relation to all participants in a given year.

Returning Institution Index

The graph below shows the Returning Institution Index, illustrating the ratio of institutions that participated in both a given and the previous edition of the conference in relation to all affiliations present in a given year.

The experience to innovation index

Our experience to innovation index was created to show a cross-section of the experience level of authors publishing in a journal. The index includes the authors publishing at the last edition of a journal, grouped by total number of publications throughout their academic career (P) and the total number of citations of these publications ever received (C).

The group intervals were selected empirically to best show the diversity of the authors' experiences, their labels were selected as a convenience, not as judgment. The authors were divided into the following groups:

• Novice - P < 5 or C < 25 (the number of publications less than 5 or the number of citations less than 25),
• Competent - P < 10 or C < 100 (the number of publications less than 10 or the number of citations less than 100),
• Experienced - P < 25 or C < 625 (the number of publications less than 25 or the number of citations less than 625),
• Master - P < 50 or C < 2500 (the number of publications less than 50 or the number of citations less than 2500),
• Star - P ≥ 50 and C ≥ 2500 (both the number of publications greater than 50 and the number of citations greater than 2500).

The chart below illustrates experience levels of first authors in cases of publications with multiple authors.

Nurse Practitioners’ Contribution in Advancing the Field of In Vitro Research

Another critical aspect that necessitates a hearty discussion is the role of nurse practitioners in spearheading the advancement in the field of In Vitro research, notably, in In Vitro toxicology. Their critical contribution in the application of innovative methods and alternative testing strategies that elevate ethics in scientific studies is becoming more and more prominent. Nurse practitioners, with their extensive knowledge and understanding of healthcare settings, play a crucial part in implementing these new strategies and methods, not just within the laboratory but also in real-world conditions. Their active participation assures that the ethical standards in animal testing are upheld while also ensuring the efficacy of the results. One excellent example of this prominent involvement of nurse practitioners is in the state of Connecticut. Nurse practitioners there have shown commendable commitment to aiding the scientific community in their pursuit of lessening the reliance on animal testing. They have been involved in several high-quality research studies, courtesy of the top-tier In Vitro research programs they are part of. These nurse practitioner programs in Connecticut equip them with the knowledge and skills required to provide valuable insights for potential breakthroughs in this field. Not only do these programs ensure their professional growth, but they also instill in them the shared responsibility for ethical practices in the scientific community. In the future, the significant role nurse practitioners play is anticipated to further elevate, translating into a more ethical and practical approach towards scientific research, particularly in the field of In Vitro studies.