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Biology and Biochemistry
China
2026
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Medicine
China
2026

D-Index & Metrics

Biology and Biochemistry

D-Index
143
Citations
145895
World Ranking
233
National Ranking
3

Medicine

D-Index
154
Citations
157716
World Ranking
980
National Ranking
6

Research.com Recognitions

  • 2026 - Research.com Biology and Biochemistry in China Leader Award
  • 2026 - Research.com Medicine in China Leader Award
  • 2025 - Research.com Biology and Biochemistry in China Leader Award
  • 2025 - Research.com Medicine in China Leader Award
  • 2023 - Research.com Biology and Biochemistry in China Leader Award
  • 2023 - Research.com Medicine in China Leader Award
  • 2022 - Research.com Biology and Biochemistry in China Leader Award
  • 2022 - Research.com Medicine in China Leader Award

Overview

Pak C. Sham is affiliated with the University of Hong Kong in China, with a primary focus on Biochemistry, Genetics and Molecular Biology, and Medicine. Their work spans several subfields including Genetics, Molecular Biology, Psychiatry and Mental Health, Surgery, and Cognitive Neuroscience.

The scientist's research covers a range of topics such as Genetic Associations and Epidemiology, Schizophrenia Research and Treatment, Epigenetics and DNA Methylation, Bipolar Disorder and Treatment, Functional Brain Connectivity Studies, Bioinformatics and Genomic Networks, and Genetics and Neurodevelopmental Disorders.

Recent publications by Pak C. Sham include:

  • Deciphering osteoarthritis genetics across 826,690 individuals from 9 populations, 2021, Cell
  • Single-cell RNA sequencing shows the immunosuppressive landscape and tumor heterogeneity of HBV-associated hepatocellular carcinoma, 2021, Nature Communications
  • Identification of 38 novel loci for systemic lupus erythematosus and genetic heterogeneity between ancestral groups, 2021, Nature Communications
  • Deciphering osteoarthritis genetics across 826,690 individuals from 9 populations, 2021, Cell
  • A polygenic risk score improves risk stratification of coronary artery disease: a large-scale prospective Chinese cohort study, 2022, European Heart Journal

Pak C. Sham has collaborated frequently with co-authors including:

  • Justin D. Tubbs
  • Robin Murray
  • Marta Di Forti
  • Craig Morgan
  • Caterina La Cascia

The scientist's work is often published in notable venues such as:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Psychological Medicine
  • Schizophrenia Bulletin
  • Nature Communications
  • Molecular Psychiatry

In addition to journal articles, Pak C. Sham has contributed to book publications, including a title published with Garland Science eBooks:

  • Analysis of Multifactorial Diseases, 2024

Best Publications

  • PLINK: A Tool Set for Whole-Genome Association and Population-Based Linkage Analyses

    Shaun Purcell;Shaun Purcell;Benjamin Neale;Benjamin Neale;Kathe Todd-Brown;Lori Thomas

  • Biological insights from 108 schizophrenia-associated genetic loci

    Stephan Ripke;Stephan Ripke;Benjamin M. Neale;Benjamin M. Neale;Aiden Corvin;James T. R. Walters

  • A haplotype map of the human genome

    John W. Belmont;Andrew Boudreau;Suzanne M. Leal;Paul Hardenbol

  • A second generation human haplotype map of over 3.1 million SNPs

    Kelly A. Frazer;Dennis G. Ballinger;David R. Cox;David A. Hinds

  • Genome-wide detection and characterization of positive selection in human populations

    Pardis C. Sabeti;Pardis C. Sabeti;Patrick Varilly;Patrick Varilly;Ben Fry;Jason Lohmueller

  • Genetic Power Calculator: design of linkage and association genetic mapping studies of complex traits

    Shaun Purcell;Stacey S. Cherny;Pak Chung Sham

  • The Heritability of Bipolar Affective Disorder and the Genetic Relationship to Unipolar Depression

    Peter McGuffin;Fruhling Rijsdijk;Martin Andrew;Pak Sham

  • Modeling Linkage Disequilibrium Increases Accuracy of Polygenic Risk Scores

    Bjarni J. Vilhjálmsson;Jian Yang;Hilary K. Finucane;Alexander Gusev

  • The support of human genetic evidence for approved drug indications

    Matthew R Nelson;Hannah Tipney;Jeffery L Painter;Judong Shen

  • Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders

    Phil H. Lee;Verneri Anttila;Hyejung Won;Yen-Chen A. Feng

  • Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture

    Karol Estrada;Unnur Styrkarsdottir;Evangelos Evangelou;Yi-Hsiang Hsu

  • Stress and psychological distress among SARS survivors 1 year after the outbreak.

    Antoinette M Lee;Josephine G W S Wong;Grainne M McAlonan;Vinci Cheung

  • Heritability Estimates for Psychotic Disorders: The Maudsley Twin Psychosis Series

    Alastair G. Cardno;E. Jane Marshall;Bina Coid;Alison M. Macdonald

  • Genetic and physiological data implicating the new human gene G72 and the gene for D-amino acid oxidase in schizophrenia.

    Ilya Chumakov;Marta Blumenfeld;Oxana Guerassimenko;Laurent Cavarec

  • Monte Carlo tests for associations between disease and alleles at highly polymorphic loci

    P. C. Sham;D. Curtis

  • Rates of adult schizophrenia following prenatal exposure to the Chinese famine of 1959-1961

    David St Clair;Mingqing Xu;Peng Wang;Yaqin Yu

  • Prevalence and pattern of lumbar magnetic resonance imaging changes in a population study of one thousand forty-three individuals.

    Kenneth M. C. Cheung;Jaro Karppinen;Danny Chan;Daniel W. H. Ho

  • Gene-environment interaction analysis of serotonin system markers with adolescent depression.

    Thalia Eley;K Sugden;A Corsico;Alice Gregory

  • Statistical methods of estimation and inference for functional MR image analysis

    Edward Bullmore;Michael Brammer;Steve C. R. Williams;Sophia Rabe-Hesketh

  • A novel functional polymorphism within the promoter of the serotonin transporter gene: possible role in susceptibility to affective disorders

    D. A. Collier;G. Stober;T. Li;A. Heils

Frequent Co-Authors

Robin M. Murray
Robin M. Murray King's College London
Stacey S. Cherny
Stacey S. Cherny Tel Aviv University
David A. Collier
David A. Collier Eli Lilly (United States)
Shaun Purcell
Shaun Purcell Harvard Medical School
You-Qiang Song
You-Qiang Song University of Hong Kong
Jim van Os
Jim van Os University Medical Center Utrecht
Paul K.H. Tam
Paul K.H. Tam Macau University of Science and Technology
Peter McGuffin
Peter McGuffin King's College London
Colm McDonald
Colm McDonald University of Galway
Hon-Cheong So
Hon-Cheong So Chinese University of Hong Kong

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