Gengfu Xiao

Best Publications

• Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro.

  Manli Wang;Ruiyuan Cao;Leike Zhang;Xinglou Yang

  7990
  Citations

• Structure of Mpro from SARS-CoV-2 and discovery of its inhibitors

  Zhenming Jin;Zhenming Jin;Xiaoyu Du;Yechun Xu;Yongqiang Deng

  4716
  Citations

• Molecular and serological investigation of 2019-nCoV infected patients: implication of multiple shedding routes.

  Wei Zhang;Rong-Hui Du;Bei Li;Xiao-Shuang Zheng

  2043
  Citations

• Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main protease.

  Wenhao Dai;Wenhao Dai;Bing Zhang;Xia Ming Jiang;Haixia Su

  1446
  Citations

• Interaction between heptad repeat 1 and 2 regions in spike protein of SARS-associated coronavirus: implications for virus fusogenic mechanism and identification of fusion inhibitors.

  Shuwen Liu;Gengfu Xiao;Yibang Chen;Yuxian He

  685
  Citations

• Discovery of a novel coronavirus associated with the recent pneumonia outbreak in humans and its potential bat origin

  Peng Zhou;Xing-Lou Yang;Xian-Guang Wang;Ben Hu

  489
  Citations

• Structural basis for the inhibition of SARS-CoV-2 main protease by antineoplastic drug carmofur.

  Zhenming Jin;Zhenming Jin;Yao Zhao;Yuan Sun;Bing Zhang

  417
  Citations

• Novel and potent inhibitors targeting DHODH are broad-spectrum antivirals against RNA viruses including newly-emerged coronavirus SARS-CoV-2.

  Unknown

  178
  Citations

• SARS-CoV-2 envelope protein causes acute respiratory distress syndrome (ARDS)-like pathological damages and constitutes an antiviral target.

  Bingqing Xia;Xurui Shen;Yang He;Xiaoyan Pan

  173
  Citations

• Structural basis for inhibition of the SARS-CoV-2 RNA polymerase by suramin.

  Wanchao Yin;Xiaodong Luan;Xiaodong Luan;Zhihai Li;Ziwei Zhou

  163
  Citations

• Screening of FDA-Approved Drugs for Inhibitors of Japanese Encephalitis Virus Infection.

  Shaobo Wang;Yang Liu;Jiao Guo;Peilin Wang

  161
  Citations

• High-throughput screening identifies established drugs as SARS-CoV-2 PLpro inhibitors.

  Yao Zhao;Xiaoyu Du;Yinkai Duan;Xiaoyan Pan

  151
  Citations

• Calcium channel blockers reduce severe fever with thrombocytopenia syndrome virus (SFTSV) related fatality

  Hao Li;Lei-Ke Zhang;Shu-Fen Li;Shao-Fei Zhang

  147
  Citations

• Absorbed plant MIR2911 in honeysuckle decoction inhibits SARS-CoV-2 replication and accelerates the negative conversion of infected patients.

  Li Kun Zhou;Li Kun Zhou;Zhen Zhou;Xia Ming Jiang;Yishan Zheng

  146
  Citations

• Structure of Mpro from COVID-19 virus and discovery of its inhibitors

  Z. Jin;Z. Jin;X. Du;Y. Xu;Y. Deng

  145
  Citations

• Following the rule: formation of the 6-helix bundle of the fusion core from severe acute respiratory syndrome coronavirus spike protein and identification of potent peptide inhibitors.

  Jieqing Zhu;Gengfu Xiao;Yanhui Xu;Fang Yuan

  143
  Citations

• SFTSV Infection Induces BAK/BAX-Dependent Mitochondrial DNA Release to Trigger NLRP3 Inflammasome Activation

  Shufen Li;Hao Li;Yu-Lan Zhang;Qi-Lin Xin

  137
  Citations

• Design and development of an oral remdesivir derivative VV116 against SARS-CoV-2.

  Yuanchao Xie;Wanchao Yin;Yumin Zhang;Weijuan Shang

  119
  Citations

• SARS coronavirus induces apoptosis in Vero E6 cells.

  Huimin Yan;Gengfu Xiao;Jiamin Zhang;Yuanyang Hu

  117
  Citations

• Structure-based drug design, virtual screening and high-throughput screening rapidly identify antiviral leads targeting COVID-19

  Zhenming Jin;Zhenming Jin;Xiaoyu Du;Yechun Xu;Yongqiang Deng

  113
  Citations