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Investigational New Drugs
H-index 29

Investigational New Drugs

0167-6997

Published by: Springer

https://www.springer.com/journal/10637

Ranking & Metrics

Discipline name Position Best Scientists Publications D-Index
Medicine 719 191 180 28

Additional Metrics

Number of Best Scientists*: 283
Documents by Best Scientists*: 252
Top 100 Ranked Scientists*: 3
SCIMAGO H-index: 100
SCIMAGO SJR: 1.074
Impact Factor: 2.7

Overview

Top Research Topics at Investigational New Drugs?

The topics of Internal medicine, Pharmacology, Chemotherapy, Oncology and Gastroenterology are the focal point of discussions in the journal. The work tackled in Investigational New Drugs goes beyond the discipline of Internal medicine as it also encompasses Surgery. Investigational New Drugs holds forums on Pharmacology that merges themes from other disciplines such as Doxorubicin, In vivo and Cytotoxicity.

The In vivo research presented in the journal explores the relationship between In vitro and the closely related topic of Cell culture. Investigational New Drugs explores topics in Chemotherapy which can be helpful for research in disciplines like Carcinoma and Pathology. Concepts in Cancer, as well as related topics in Cancer research, are covered in the Oncology research presented in Investigational New Drugs.

The concepts on Cancer research presented in Investigational New Drugs can also apply to other research fields, including Cancer cell and Immunology. The research on Gastroenterology featured in Investigational New Drugs combines topics in other fields like Refractory, Anemia, Vomiting, Leukopenia and Nausea. The studies on Pharmacokinetics discussed can also contribute to research in the domains of Tolerability and Dosing.

  • Internal medicine (49.91%)
  • Pharmacology (27.19%)
  • Chemotherapy (25.61%)

What are the most cited papers published in the journal?

  • Southwest Oncology Group standard response criteria, endpoint definitions and toxicity criteria. (575 citations)
  • Matrix metalloproteinase inhibitors (510 citations)
  • Orthotopic metastatic mouse models for anticancer drug discovery and evaluation: a bridge to the clinic. (484 citations)

Research areas of the most cited articles at Investigational New Drugs:

The most cited publications investigate areas of study like Internal medicine, Pharmacology, Chemotherapy, Oncology and Surgery. The journal papers connects research in Internal medicine with the related topics of Gastroenterology. In addition to Pharmacology research, the most cited publications aim to explore topics under Cancer, Apoptosis and In vivo.

What topics the last edition of the journal is best known for?

  • Cancer
  • Internal medicine
  • Gene

The previous edition focused in particular on these issues:

The discussions in the journal mainly cover the fields of Internal medicine, Cancer research, Oncology, Adverse effect and Gastroenterology. Internal medicine studies presented include Chemotherapy, Pharmacokinetics, Neutropenia, Tolerability and Cancer. The presentations focused mostly on Pharmacokinetics in an attempt to further explore topics in Pharmacology.

Investigational New Drugs explores issues in Oncology which can be linked to other research areas like Tyrosine-kinase inhibitor, Clinical trial, Phases of clinical research and Retrospective cohort study. In it, Refractory, Vomiting, Toxicity, Nausea and Rash are investigated in conjunction with one another to address concerns in Adverse effect research. Investigational New Drugs explores research in Gastroenterology alongside concepts in Gemcitabine and other areas of study in Pancreatic cancer.

The most cited articles from the last journal are:

  • Recombinant human lactoferrin carrying humanized glycosylation exhibits antileukemia selective cytotoxicity, microfilament disruption, cell cycle arrest, and apoptosis activities (7 citations)
  • Pembrolizumab for advanced penile cancer: a case series from a phase II basket trial. (6 citations)
  • Autophagy modulating agents as chemosensitizers for cisplatin therapy in cancer (6 citations)

Papers citation over time

A key indicator for each journal is its effectiveness in reaching other researchers with the papers published at that venue.

The chart below presents the interquartile range (first quartile 25%, median 50% and third quartile 75%) of the number of citations of articles over time.

The top authors publishing in Investigational New Drugs (based on the number of publications) are:

  • Patricia LoRusso (55 papers) published 2 papers at the last edition the same number as at the previous edition,
  • Jos H. Beijnen (51 papers) published 1 paper at the last edition, 3 less than at the previous edition,
  • Jan H.M. Schellens (47 papers) absent at the last edition,
  • Daniel D. Von Hoff (31 papers) absent at the last edition,
  • James L. Abbruzzese (30 papers) absent at the last edition.

The overall trend for top authors publishing in this journal is outlined below. The chart shows the number of publications at each edition of the journal for top authors.

Only papers with recognized affiliations are considered

The top affiliations publishing in Investigational New Drugs (based on the number of publications) are:

  • University of Texas MD Anderson Cancer Center (201 papers) published 17 papers at the last edition, 12 more than at the previous edition,
  • Memorial Sloan Kettering Cancer Center (108 papers) published 7 papers at the last edition the same number as at the previous edition,
  • Wayne State University (105 papers) published 1 paper at the last edition the same number as at the previous edition,
  • Harvard University (90 papers) published 6 papers at the last edition, 4 less than at the previous edition,
  • Ohio State University (84 papers) published 1 paper at the last edition, 3 less than at the previous edition.

The overall trend for top affiliations publishing in this journal is outlined below. The chart shows the number of publications at each edition of the journal for top affiliations.

Publication chance based on affiliation

The publication chance index shows the ratio of articles published by the best research institutions in the journal edition to all articles published within that journal. The best research institutions were selected based on the largest number of articles published during all editions of the journal.

The chart below presents the percentage ratio of articles from top institutions (based on their ranking of total papers).Top affiliations were grouped by their rank into the following tiers: top 1-10, top 11-20, top 21-50, and top 51+. Only articles with a recognized affiliation are considered.

During the most recent 2021 edition, 6.64% of publications had an unrecognized affiliation. Out of the publications with recognized affiliations, 18.27% were posted by at least one author from the top 10 institutions publishing in the journal. Another 2.03% included authors affiliated with research institutions from the top 11-20 affiliations. Institutions from the 21-50 range included 7.11% of all publications and 72.59% were from other institutions.

Returning Authors Index

A very common phenomenon observed among researchers publishing scientific articles is the intentional selection of journals they have already attended in the past. In particular, it is worth analyzing the case when the authors participate in the same journal from year to year.

The Returning Authors Index presented below illustrates the ratio of authors who participated in both a given as well as the previous edition of the journal in relation to all participants in a given year.

Returning Institution Index

The graph below shows the Returning Institution Index, illustrating the ratio of institutions that participated in both a given and the previous edition of the conference in relation to all affiliations present in a given year.

The experience to innovation index

Our experience to innovation index was created to show a cross-section of the experience level of authors publishing in a journal. The index includes the authors publishing at the last edition of a journal, grouped by total number of publications throughout their academic career (P) and the total number of citations of these publications ever received (C).

The group intervals were selected empirically to best show the diversity of the authors' experiences, their labels were selected as a convenience, not as judgment. The authors were divided into the following groups:

  • Novice - P < 5 or C < 25 (the number of publications less than 5 or the number of citations less than 25),
  • Competent - P < 10 or C < 100 (the number of publications less than 10 or the number of citations less than 100),
  • Experienced - P < 25 or C < 625 (the number of publications less than 25 or the number of citations less than 625),
  • Master - P < 50 or C < 2500 (the number of publications less than 50 or the number of citations less than 2500),
  • Star - P ≥ 50 and C ≥ 2500 (both the number of publications greater than 50 and the number of citations greater than 2500).

The chart below illustrates experience levels of first authors in cases of publications with multiple authors.

Career Paths in Medical Research

While the above information is essential for researchers studying the given domains, it may also be of great interest to aspiring pharmaceutical professionals to comprehend how understanding these research topics can propel their careers forward. Equipped with the knowledge of predominant research topics and the methodologies around them, one may find oneself at a vantage point while transitioning towards a career in medical research. For instance, understanding the implications of Oncology research and developing a nuanced perception of concepts in chemotherapy could be advantageous for those considering to become a nurse in Hawaii. To know more about this specific career path, you may want to delve deeper into our comprehensive guide on {anchor}. Additionally, being familiar with the research work being conducted in Gastroenterology, and the underlying concepts of Cancer cell and Immunology, could prove beneficial for those looking to specialize in Internal Medicine. Awareness about the most cited papers, as well as understanding the areas explored in the last edition, can offer insights into the current trends and future pathways in medical research. Hence, exploring research on a granular level not only contributes to academic progression but also provides a roadmap to a successful medical career. Stay updated, keep learning, and keep growing in your professional journey in healthcare. The road to excellence and success begins with a step of determination and continues with consistent learning. Remember, every research article could be a stepping stone in understanding, combating, and curing a medical ailment and launching an impactful career in healthcare.

Top Publications

  • Phase 1b study of a small molecule antagonist of human chemokine (C-C motif) receptor 2 (PF-04136309) in combination with nab-paclitaxel/gemcitabine in first-line treatment of metastatic pancreatic ductal adenocarcinoma

    Marcus Noel;Eileen M O'Reilly;Brian M Wolpin;David P Ryan

    (2020)
    157 Citations
  • First-in-human phase I study of JPH203, an L-type amino acid transporter 1 inhibitor, in patients with advanced solid tumors

    (2020)
    136 Citations
  • Clinical pharmacokinetics and pharmacodynamics of ivosidenib, an oral, targeted inhibitor of mutant IDH1, in patients with advanced solid tumors.

    Bin Fan;Ingo K. Mellinghoff;Patrick Y. Wen;Maeve A. Lowery

    (2020)
    101 Citations
  • Phase 1 study of the MDM2 inhibitor AMG 232 in patients with advanced P53 wild-type solid tumors or multiple myeloma

    W. Larry Gluck;Mrinal M. Gounder;Richard Frank;Ferry Eskens

    (2020)
    88 Citations
  • Phase 1b/2a study of galunisertib, a small molecule inhibitor of transforming growth factor-beta receptor I, in combination with standard temozolomide-based radiochemotherapy in patients with newly diagnosed malignant glioma.

    Antje Wick;Annick Desjardins;Cristina Suarez;Peter Forsyth

    (2020)
    87 Citations
  • Veliparib in ovarian cancer: a new synthetically lethal therapeutic approach

    Stergios Boussios;Peeter Karihtala;Michele Moschetta;Charlotte Abson

    (2020)
    79 Citations
  • A phase 1b dose escalation study of Wnt pathway inhibitor vantictumab in combination with nab-paclitaxel and gemcitabine in patients with previously untreated metastatic pancreatic cancer.

    S. Lindsey Davis;Dana B. Cardin;Safi Shahda;Heinz-Josef Lenz

    (2020)
    76 Citations
  • Phase 1 study of the protein deubiquitinase inhibitor VLX1570 in patients with relapsed and/or refractory multiple myeloma

    Eric K. Rowinsky;Agne Paner;Jesus G. Berdeja;Claudia Paba-Prada

    (2020)
    68 Citations
  • Phase Ib study of the MEK inhibitor cobimetinib (GDC-0973) in combination with the PI3K inhibitor pictilisib (GDC-0941) in patients with advanced solid tumors

    Geoffrey I. Shapiro;Patricia LoRusso;Eunice Kwak;Susan Pandya

    (2020)
    67 Citations
  • A phase Ib study of the highly selective MET-TKI savolitinib plus gefitinib in patients with EGFR -mutated, MET -amplified advanced non-small-cell lung cancer

    Jin-Ji Yang;Jian Fang;Yong-Qian Shu;Jian-Hua Chang

    (2021)
    61 Citations

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