Lei Xie

Lei Xie publication distribution in Computer Science in 2026

The chart shows the distribution of publications by all Research.com ranked scientists in the field of Computer Science in 2026. The highlighted bar marks where Lei Xie sits on this spectrum.

Lei Xie D-index placement in Computer Science in 2026

The chart shows the D-index (discipline H-index) distribution of Computer Science scientists ranked by Research.com in 2026. The highlighted bar marks where Lei Xie sits on this spectrum.

Best Publications

• Drug discovery using chemical systems biology: repositioning the safe medicine Comtan to treat multi-drug and extensively drug resistant tuberculosis.

  Sarah L. Kinnings;Nina Liu;Nancy Buchmeier;Peter J. Tonge

  385
  Citations

• Drug discovery using chemical systems biology: identification of the protein-ligand binding network to explain the side effects of CETP inhibitors.

  Li Xie;Jerry Li;Lei Xie;Philip E. Bourne;Philip E. Bourne

  321
  Citations

• Detecting evolutionary relationships across existing fold space, using sequence order-independent profile-profile alignments.

  Lei Xie;Philip E. Bourne

  276
  Citations

• A Machine Learning-Based Method To Improve Docking Scoring Functions and Its Application to Drug Repurposing

  Sarah L. Kinnings;Nina Liu;Peter J. Tonge;Richard M. Jackson

  251
  Citations

• Drug off-target effects predicted using structural analysis in the context of a metabolic network model.

  Roger L. Chang;Li Xie;Lei Xie;Philip E. Bourne;Philip E. Bourne

  246
  Citations

• The Cancer Microbiome: Distinguishing Direct and Indirect Effects Requires a Systemic View

  Joao B. Xavier;Vincent B. Young;Joseph Skufca;Fiona Ginty

  245
  Citations

• Novel computational approaches to polypharmacology as a means to define responses to individual drugs.

  Lei Xie;Li Xie;Sarah L. Kinnings;Philip E. Bourne

  233
  Citations

• TranSynergy: Mechanism-driven interpretable deep neural network for the synergistic prediction and pathway deconvolution of drug combinations

  Unknown

  195
  Citations

• A deep learning framework for high-throughput mechanism-driven phenotype compound screening and its application to COVID-19 drug repurposing

  Unknown

  191
  Citations

• Drug Discovery Using Chemical Systems Biology: Weak Inhibition of Multiple Kinases May Contribute to the Anti-Cancer Effect of Nelfinavir

  Li Xie;Thomas Evangelidis;Lei Xie;Lei Xie;Philip E. Bourne

  190
  Citations

• A robust and efficient algorithm for the shape description of protein structures and its application in predicting ligand binding sites

  Lei Xie;Philip E Bourne

  180
  Citations

• Structure-based Systems Biology for Analyzing Off-target Binding

  Lei Xie;Li Xie;Philip E Bourne

  177
  Citations

• Quantifying reproducibility in computational biology: the case of the tuberculosis drugome.

  Daniel Garijo;Sarah Kinnings;Li Xie;Lei Xie

  127
  Citations

• The Mycobacterium tuberculosis Drugome and Its Polypharmacological Implications

  Unknown

  119
  Citations

• A unified statistical model to support local sequence order independent similarity searching for ligand-binding sites and its application to genome-based drug discovery

  Lei Xie;Li Xie;Philip E. Bourne

  118
  Citations

• In Silico Elucidation of the Molecular Mechanism Defining the Adverse Effect of Selective Estrogen Receptor Modulators

  Lei Xie;Jian Wang;Philip E Bourne;Philip E Bourne

  105
  Citations

• A multidimensional strategy to detect polypharmacological targets in the absence of structural and sequence homology.

  Jacob D. Durrant;Rommie E. Amaro;Lei Xie;Michael D. Urbaniak

  104
  Citations

• Heterogeneous Multi-Layered Network Model for Omics Data Integration and Analysis.

  Unknown

  103
  Citations

• Functional Coverage of the Human Genome by Existing Structures, Structural Genomics Targets, and Homology Models

  Lei Xie;Philip E Bourne

  91
  Citations

• WeNet 2.0: More Productive End-to-End Speech Recognition Toolkit

  Unknown

  91
  Citations