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Wolfgang Löscher

Wolfgang Löscher

University of Veterinary Medicine Hannover, Foundation
Germany

Overview

What is he best known for?

The fields of study he is best known for:

  • Internal medicine
  • Gene
  • Epilepsy

The scientist’s investigation covers issues in Epilepsy, Pharmacology, Neuroscience, Epileptogenesis and Anticonvulsant. His work deals with themes such as Drug resistance, Drug and Intensive care medicine, which intersect with Epilepsy. Wolfgang Löscher has researched Pharmacology in several fields, including P-glycoprotein, Transporter, ATP-binding cassette transporter and Blood–brain barrier.

His studies deal with areas such as Animal model, Drug treatment and Voltage-dependent calcium channel as well as Neuroscience. His Epileptogenesis research is multidisciplinary, relying on both Stroke and Neuroprotection. His studies in Anticonvulsant integrate themes in fields like Substantia nigra, Carbamazepine, Phenytoin and Stimulation.

His most cited work include:

  • The neurobiology of antiepileptic drugs. (882 citations)
  • Which animal models should be used in the search for new antiepileptic drugs? A proposal based on experimental and clinical considerations (726 citations)
  • Drug resistance in brain diseases and the role of drug efflux transporters (685 citations)

What are the main themes of his work throughout his whole career to date?

His primary areas of study are Epilepsy, Pharmacology, Neuroscience, Epileptogenesis and Status epilepticus. His Epilepsy research incorporates elements of Anesthesia, Hippocampus and Drug. His biological study spans a wide range of topics, including P-glycoprotein, Tariquidar, Transporter and Blood–brain barrier.

His work on Neuroscience is being expanded to include thematically relevant topics such as Internal medicine. Wolfgang Löscher interconnects Stroke, Neuroprotection and Intensive care medicine in the investigation of issues within Epileptogenesis. His study explores the link between Status epilepticus and topics such as Kainate receptor that cross with problems in Kainic acid.

He most often published in these fields:

  • Epilepsy (56.34%)
  • Pharmacology (42.77%)
  • Neuroscience (23.30%)

What were the highlights of his more recent work (between 2015-2021)?

  • Epilepsy (56.34%)
  • Pharmacology (42.77%)
  • Epileptogenesis (19.17%)

In recent papers he was focusing on the following fields of study:

Epilepsy, Pharmacology, Epileptogenesis, Hippocampus and Neuroscience are his primary areas of study. He combines subjects such as Anesthesia and Kainate receptor with his study of Epilepsy. His research in Anesthesia intersects with topics in Anticonvulsant and Cohort.

In general Pharmacology, his work in Phenobarbital and Drug is often linked to Bumetanide linking many areas of study. His work deals with themes such as Drug development, Immune system, Neuroinflammation, Encephalitis and Extravasation, which intersect with Epileptogenesis. His work carried out in the field of Hippocampus brings together such families of science as Hippocampal formation, Carbamazepine and Neurodegeneration.

Between 2015 and 2021, his most popular works were:

  • Infections, inflammation and epilepsy (183 citations)
  • Advances in the development of biomarkers for epilepsy (159 citations)
  • Mechanisms of Action of Antiseizure Drugs and the Ketogenic Diet (127 citations)

In his most recent research, the most cited papers focused on:

  • Internal medicine
  • Gene
  • Cancer

His main research concerns Epilepsy, Pharmacology, Epileptogenesis, Neuroscience and Status epilepticus. His Epilepsy research integrates issues from Neurology, Encephalitis and Intensive care medicine. His work in the fields of Pharmacology, such as Phenobarbital, overlaps with other areas such as Bumetanide.

His research integrates issues of Clinical trial, Drug development, Central nervous system, Stroke and Neuroinflammation in his study of Epileptogenesis. His Neuroscience research includes elements of Quantitative trait locus, Genetic heterogeneity, Epigenetics and Inbred strain. As a part of the same scientific family, Wolfgang Löscher mostly works in the field of Status epilepticus, focusing on Kainic acid and, on occasion, Hippocampus, Kainate receptor, Isoflurane and Anesthesia.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

The neurobiology of antiepileptic drugs.

Michael A. Rogawski;Wolfgang Löscher.
Nature Reviews Neuroscience (2004)

1325 Citations

Which animal models should be used in the search for new antiepileptic drugs? A proposal based on experimental and clinical considerations

Wolfgang Löscher;Dieter Schmidt.
Epilepsy Research (1988)

1006 Citations

Drug resistance in brain diseases and the role of drug efflux transporters

Wolfgang Löscher;Heidrun Potschka.
Nature Reviews Neuroscience (2005)

965 Citations

Blood-Brain Barrier Active Efflux Transporters: ATP-Binding Cassette Gene Family

Wolfgang Löscher;Heidrun Potschka.
Neurorx (2005)

891 Citations

Critical review of current animal models of seizures and epilepsy used in the discovery and development of new antiepileptic drugs.

Wolfgang Löscher.
Seizure-european Journal of Epilepsy (2011)

846 Citations

Basic pharmacology of valproate: a review after 35 years of clinical use for the treatment of epilepsy.

Wolfgang Löscher.
CNS Drugs (2002)

815 Citations

The blood-brain barrier and cancer: transporters, treatment, and Trojan horses.

John F. Deeken;Wolfgang Löscher.
Clinical Cancer Research (2007)

741 Citations

Role of drug efflux transporters in the brain for drug disposition and treatment of brain diseases

Wolfgang Löscher;Heidrun Potschka.
Progress in Neurobiology (2005)

703 Citations

Valproate: a reappraisal of its pharmacodynamic properties and mechanisms of action

Wolfgang Löscher.
Progress in Neurobiology (1999)

635 Citations

Drug resistance in epilepsy : Putative neurobiologic and clinical mechanisms

Dieter Schmidt;Wolfgang Löscher.
Epilepsia (2005)

601 Citations

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