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William M. Abraham

William M. Abraham

Mount Sinai Hospital
United States

Overview

What is he best known for?

The fields of study he is best known for:

Internal medicine
Enzyme
Biochemistry

His primary areas of study are Immunology, Antigen, Pharmacology, Airway resistance and Bronchoconstriction. His Immunology study combines topics in areas such as Bronchoalveolar lavage and Histamine. William M. Abraham interconnects CD49d and Antibody in the investigation of issues within Antigen.

His Pharmacology research includes themes of Endocrinology, Carbachol, Internal medicine, Cystic fibrosis and Mucociliary clearance. His work carried out in the field of Airway resistance brings together such families of science as Marine toxin, Intensive care and Heparin. The various areas that William M. Abraham examines in his Bronchoconstriction study include Inhalation and Red tide.

His most cited work include:

Literature Review of Florida Red Tide: Implications for Human Health Effects. (278 citations)
Alpha 4-integrins mediate antigen-induced late bronchial responses and prolonged airway hyperresponsiveness in sheep. (231 citations)
Tryptase inhibitors block allergen-induced airway and inflammatory responses in allergic sheep. (202 citations)

What are the main themes of his work throughout his whole career to date?

William M. Abraham mostly deals with Immunology, Pharmacology, Bronchoconstriction, Internal medicine and Antigen. His Immunology research is multidisciplinary, relying on both Bronchoalveolar lavage and Airway. His studies in Airway integrate themes in fields like Asthma and Respiratory system.

His studies deal with areas such as Receptor, Antagonist, Cystic fibrosis, Heparin and Mucociliary clearance as well as Pharmacology. His Bronchoconstriction study deals with Histamine intersecting with Mast cell. In his study, which falls under the umbrella issue of Internal medicine, Mucus is strongly linked to Endocrinology.

He most often published in these fields:

Immunology (43.09%)
Pharmacology (30.89%)
Bronchoconstriction (23.98%)

What were the highlights of his more recent work (between 2010-2020)?

Pharmacology (30.89%)
Immunology (43.09%)
Asthma (13.82%)

In recent papers he was focusing on the following fields of study:

William M. Abraham mainly investigates Pharmacology, Immunology, Asthma, Airway and Karenia brevis. His Pharmacology study combines topics in areas such as Mucus, Cystic fibrosis, Heparin and Lung, Mucociliary clearance. In general Immunology, his work in Bronchoconstriction and Antigen is often linked to Syk linking many areas of study.

His Bronchoconstriction study combines topics from a wide range of disciplines, such as Receptor, Antagonist, Prostaglandin and Allergic inflammation. In his research on the topic of Antigen, Histamine, Oligosaccharide and Eosinophil is strongly related with Airway resistance. The concepts of his Airway study are interwoven with issues in Inflammation and Pathology.

Between 2010 and 2020, his most popular works were:

Review of Florida Red Tide and Human Health Effects. (113 citations)
Review of Florida Red Tide and Human Health Effects. (113 citations)
Characterization of a late phase pulmonary response after antigen challenge in allergic sheep. (80 citations)

In his most recent research, the most cited papers focused on:

Internal medicine
Enzyme
Biochemistry

His scientific interests lie mostly in Pharmacology, Mucus, Immunology, Cystic fibrosis and Karenia brevis. His Pharmacology study incorporates themes from Receptor, Chemotaxis, Antagonist and Ex vivo. His research in Mucus focuses on subjects like Airway, which are connected to Neutrophil elastase.

His Immunology study integrates concerns from other disciplines, such as Inhalation and Late phase. In Lung, William M. Abraham works on issues like Endocrinology, which are connected to Internal medicine. His work deals with themes such as Gastroenterology, Antigen, Antigen challenge and Allergic inflammation, which intersect with Bronchoconstriction.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

Literature Review of Florida Red Tide: Implications for Human Health Effects.

Barbara Kirkpatrick;Lora E. Fleming;Dominick Squicciarini;Lorrie C. Backer.
Harmful Algae (2004)

420 Citations

Alpha 4-integrins mediate antigen-induced late bronchial responses and prolonged airway hyperresponsiveness in sheep.

W M Abraham;M W Sielczak;A Ahmed;A Cortes.
Journal of Clinical Investigation (1994)

351 Citations

Tryptase inhibitors block allergen-induced airway and inflammatory responses in allergic sheep.

James M. Clark;William M. Abraham;Cindy E. Fishman;Rosanna Forteza.
American Journal of Respiratory and Critical Care Medicine (1995)

306 Citations

The porcine lung as a potential model for cystic fibrosis.

Christopher S. Rogers;William M. Abraham;Kim A. Brogden;John F. Engelhardt.
American Journal of Physiology-lung Cellular and Molecular Physiology (2008)

276 Citations

The Lactoperoxidase System Functions in Bacterial Clearance of Airways

Cynthia Gerson;Juan Sabater;Mario Scuri;Mario Scuri;Aliza Torbati;Aliza Torbati.
American Journal of Respiratory Cell and Molecular Biology (2000)

223 Citations

Discovery of a potent and selective prostaglandin D2 receptor antagonist, [(3R)-4-(4-chloro-benzyl)-7-fluoro-5-(methylsulfonyl)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl]-acetic acid (MK-0524).

Claudio F. Sturino;Gary O'Neill;Nicolas Lachance;Michael Boyd.
Journal of Medicinal Chemistry (2007)

219 Citations

Pharmacology of INS37217 [P(1)-(uridine 5')-P(4)- (2'-deoxycytidine 5')tetraphosphate, tetrasodium salt], a next-generation P2Y(2) receptor agonist for the treatment of cystic fibrosis.

B. R. Yerxa;J. R. Sabater;C. W. Davis;M. J. Stutts.
Journal of Pharmacology and Experimental Therapeutics (2002)

214 Citations

Inhaled tryptase causes bronchoconstriction in sheep via histamine release.

Jussara F. Molinari;Mario Scuri;William R. Moore;James Clark.
American Journal of Respiratory and Critical Care Medicine (1996)

188 Citations

Review of Florida Red Tide and Human Health Effects.

Lora E. Fleming;Barbara Kirkpatrick;Lorraine C. Backer;Cathy J. Walsh.
Harmful Algae (2011)

188 Citations

Pharmacology of MK-0591 (3-[1-(4-chlorobenzyl)-3-(t-butylthio)-5-(quinolin-2-yl-methoxy)- indol-2-yl]-2,2-dimethyl propanoic acid), a potent, orally active leukotriene biosynthesis inhibitor.

Christine Brideau;Chi-Chung Chan;S. Charleson;Deschenes Denis.
Canadian Journal of Physiology and Pharmacology (1992)

165 Citations

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