D-Index & Metrics Best Publications

D-Index & Metrics D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines.

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Biology and Biochemistry D-index 44 Citations 7,617 59 World Ranking 16242 National Ranking 6731

Overview

What is he best known for?

The fields of study he is best known for:

  • Enzyme
  • Gene
  • Cancer

Cancer research, Prenylation, Farnesyltransferase, Biochemistry and Geranylgeranyltransferase I Inhibitor are his primary areas of study. The Cancer research study combines topics in areas such as Protein kinase B and Cell growth. His study in Prenylation is interdisciplinary in nature, drawing from both 3T3 cells and Kinase.

Saïd M. Sebti has included themes like Signal transduction and Cell biology in his Farnesyltransferase study. His work in Growth inhibition and Apoptosis is related to Biochemistry. His research in Growth inhibition intersects with topics in Farnesyltranstransferase and Enzyme inhibitor.

His most cited work include:

  • Targeting protein prenylation for cancer therapy (393 citations)
  • Ras CAAX peptidomimetic FTI-277 selectively blocks oncogenic Ras signaling by inducing cytoplasmic accumulation of inactive Ras-Raf complexes. (345 citations)
  • Ras CAAX Peptidomimetic FTI 276 Selectively Blocks Tumor Growth in Nude Mice of a Human Lung Carcinoma with K-Ras Mutation and p53 Deletion (218 citations)

What are the main themes of his work throughout his whole career to date?

Saïd M. Sebti focuses on Cancer research, Biochemistry, Farnesyltransferase, Prenylation and Cell biology. The concepts of his Cancer research study are interwoven with issues in Cell growth, Carcinogenesis, Signal transduction, Cell cycle and Kinase. His work deals with themes such as Endocrinology and Internal medicine, which intersect with Signal transduction.

His research integrates issues of Stereochemistry and Enzyme inhibitor in his study of Farnesyltransferase. He focuses mostly in the field of Prenylation, narrowing it down to matters related to Growth inhibition and, in some cases, STAT3. His Cell biology study integrates concerns from other disciplines, such as Malignant transformation and Molecular biology.

He most often published in these fields:

  • Cancer research (43.75%)
  • Biochemistry (39.06%)
  • Farnesyltransferase (40.62%)

What were the highlights of his more recent work (between 2005-2019)?

  • Cancer research (43.75%)
  • Prenylation (35.94%)
  • Cell biology (18.75%)

In recent papers he was focusing on the following fields of study:

Saïd M. Sebti mainly investigates Cancer research, Prenylation, Cell biology, Farnesyltransferase and Molecular biology. His studies deal with areas such as Caspase 3, Pancreatic cancer, Carcinogenesis, KRAS and Kinase as well as Cancer research. The study incorporates disciplines such as Cohort study and Dose–response relationship in addition to Prenylation.

In Cell biology, Saïd M. Sebti works on issues like Malignant transformation, which are connected to SH2 domain, MMP9, Binding site and Mutant. His Farnesyltransferase research is multidisciplinary, incorporating elements of In vitro and Tumor growth. Saïd M. Sebti combines subjects such as Apoptosis, Membrane, Bcl-2 family, Cytotoxicity and Akt phosphorylation with his study of Molecular biology.

Between 2005 and 2019, his most popular works were:

  • Targeting protein prenylation for cancer therapy (393 citations)
  • The BH3 α-helical mimic BH3-M6 disrupts Bcl-XL, Bcl-2, and MCL-1 protein-protein interactions with Bax, Bak, Bad, or Bim and induces apoptosis in a Bax- and Bim-dependent manner (95 citations)
  • A novel inhibitor of STAT3 homodimerization selectively suppresses STAT3 activity and malignant transformation (92 citations)

In his most recent research, the most cited papers focused on:

  • Gene
  • Enzyme
  • Cancer

Saïd M. Sebti spends much of his time researching Cell biology, Prenylation, Protein prenylation, Geranylgeranylation and Clinical trial. His work carried out in the field of Cell biology brings together such families of science as Molecular biology, MMP9 and Binding site. He has included themes like GTPase, RALB, RALA, Ral GTP-Binding Proteins and Growth inhibition in his Prenylation study.

His research in Clinical trial intersects with topics in Protein farnesylation, Farnesyltransferase, Signal transduction, Pharmacology and Cancer therapy.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

Targeting protein prenylation for cancer therapy

Norbert Berndt;Andrew D. Hamilton;Saïd M. Sebti.
Nature Reviews Cancer (2011)

667 Citations

Ras CAAX peptidomimetic FTI-277 selectively blocks oncogenic Ras signaling by inducing cytoplasmic accumulation of inactive Ras-Raf complexes.

Edwina C. Lerner;Yimin Qian;Michelle A. Blaskovich;Renae D. Fossum.
Journal of Biological Chemistry (1995)

455 Citations

Cucurbitacin Q: a selective STAT3 activation inhibitor with potent antitumor activity.

Jiazhi Sun;Michelle A Blaskovich;Richard Jove;Sandra K Livingston.
Oncogene (2005)

318 Citations

Ras CAAX Peptidomimetic FTI 276 Selectively Blocks Tumor Growth in Nude Mice of a Human Lung Carcinoma with K-Ras Mutation and p53 Deletion

Jiazhi Sun;Yimin Qian;Andrew D. Hamilton;Saïd M. Sebti.
Cancer Research (1995)

288 Citations

Disruption of oncogenic K-Ras4B processing and signaling by a potent geranylgeranyltransferase I inhibitor

Edwina C. Lerner;Yimin Qian;Andrew D. Hamilton;Saïd M. Sebti.
Journal of Biological Chemistry (1995)

267 Citations

Both farnesylated and geranylgeranylated RhoB inhibit malignant transformation and suppress human tumor growth in nude mice.

Zhi Chen;Jiazhi Sun;Anne Pradines;Gilles Favre.
Journal of Biological Chemistry (2000)

256 Citations

Inhibition of the prenylation of K-Ras, but not H- or N-Ras, is highly resistant to CAAX peptidomimetics and requires both a farnesyltransferase and a geranylgeranyltransferase I inhibitor in human tumor cell lines.

Edwina C. Lerner;Ting Ting Zhang;David B. Knowles;Yimin Qian.
Oncogene (1997)

241 Citations

The Geranylgeranyltransferase-I Inhibitor GGTI-298 Arrests Human Tumor Cells in G0/G1 and Induces p21WAF1/CIP1/SDI1 in a p53-independent Manner *

Andreas Vogt;Jiazhi Sun;Yimin Qian;Andrew D. Hamilton.
Journal of Biological Chemistry (1997)

237 Citations

Akt Mediates Ras Downregulation of RhoB, a Suppressor of Transformation, Invasion, and Metastasis

Kun Jiang;Jiazhi Sun;Jin Cheng;Julie Y. Djeu.
Molecular and Cellular Biology (2004)

223 Citations

Inhibitors of protein isoprenyl transferases

David J. Augeri;Kenneth J. Barr;Bernard G. Donner;Stephen A. Fakhhoury.
(1998)

220 Citations

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