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N. van Rooijen

N. van Rooijen

Vrije Universiteit Amsterdam
Netherlands

Overview

What is he best known for?

The fields of study he is best known for:

  • Immune system
  • Internal medicine
  • Antibody

N. van Rooijen mainly focuses on Macrophage, Immunology, Liposome, Spleen and Pathology. His Macrophage research includes elements of Molecular biology, Corneal Infection, Immune system and Lymphocyte. His study in Immune system is interdisciplinary in nature, drawing from both Antibody and Antigen.

The concepts of his Immunology study are interwoven with issues in Lung and Lymph. The Liposome study combines topics in areas such as Cell, Dichloromethylene Diphosphonate, Pharmacology and Intracellular. His biological study spans a wide range of topics, including Endocrinology, Peritoneum and Monoclonal antibody.

His most cited work include:

  • Liposome mediated depletion of macrophages: mechanism of action, preparation of liposomes and applications. (1529 citations)
  • Depletion of hematogenous macrophages promotes partial hindlimb recovery and neuroanatomical repair after experimental spinal cord injury. (584 citations)
  • Suppression of experimental allergic encephalomyelitis in Lewis rats after elimination of macrophages. (454 citations)

What are the main themes of his work throughout his whole career to date?

Immunology, Spleen, Immune system, Macrophage and Antigen are his primary areas of study. His work carried out in the field of Immunology brings together such families of science as Liposome and Lung. His work deals with themes such as Molecular biology, Marginal zone, Lymphocyte and Pathology, which intersect with Spleen.

His Immune system study which covers Lymphatic system that intersects with Germinal center. His studies in Macrophage integrate themes in fields like Endocrinology, Phagocytosis, Intracellular, Cell biology and Internal medicine. His study focuses on the intersection of Antigen and fields such as Antibody with connections in the field of Immunocytochemistry, Cytochemistry, Horseradish peroxidase and Biochemistry.

He most often published in these fields:

  • Immunology (44.69%)
  • Spleen (34.96%)
  • Immune system (30.53%)

What were the highlights of his more recent work (between 2003-2016)?

  • Immunology (44.69%)
  • Pathology (22.12%)
  • Macrophage (30.09%)

In recent papers he was focusing on the following fields of study:

His primary areas of study are Immunology, Pathology, Macrophage, Cancer research and Molecular biology. He specializes in Immunology, namely Inflammation. His Pathology study combines topics in areas such as Macrophage depletion, Membrane and Liposome.

He has included themes like Immunofluorescence, Apoptosis, Effector and Immunohistochemistry in his Macrophage study. N. van Rooijen works mostly in the field of Molecular biology, limiting it down to topics relating to In vitro and, in certain cases, Transforming growth factor beta, Mesenchymal stem cell and Synovial membrane, as a part of the same area of interest. As a part of the same scientific family, N. van Rooijen mostly works in the field of Mechanism of action, focusing on Ovalbumin and, on occasion, Antibody and Endocrinology.

Between 2003 and 2016, his most popular works were:

  • Gliomas induce and exploit microglial MT1-MMP expression for tumor expansion (256 citations)
  • Eosinophils develop in distinct stages and are recruited to peripheral sites by alternatively activated macrophages (138 citations)
  • Crucial role of synovial lining macrophages in the promotion of transforming growth factor beta-mediated osteophyte formation. (132 citations)

In his most recent research, the most cited papers focused on:

  • Immune system
  • Internal medicine
  • Antibody

His primary areas of investigation include Immunology, Molecular biology, Cancer research, Pathology and Microglia. His Immunology study frequently draws connections to other fields, such as Macrophage. His studies deal with areas such as Mesenchymal stem cell, Bone morphogenetic protein 2 and Synovial membrane as well as Macrophage.

His research integrates issues of Tropism, Transforming growth factor beta and Interferon, Virology in his study of Molecular biology. His Cancer research research incorporates themes from Receptor and Antibody. His study on Pathology is mostly dedicated to connecting different topics, such as Spleen.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

Liposome mediated depletion of macrophages: mechanism of action, preparation of liposomes and applications.

N Van Rooijen;A Sanders.
Journal of Immunological Methods (1994)

1989 Citations

Depletion of hematogenous macrophages promotes partial hindlimb recovery and neuroanatomical repair after experimental spinal cord injury.

P. G. Popovich;Zhen Guan;Ping Wei;I. Huitinga.
Experimental Neurology (1999)

796 Citations

The liposome-mediated macrophage ‘suicide’ technique

N. Van Rooijen.
Journal of Immunological Methods (1989)

616 Citations

Suppression of experimental allergic encephalomyelitis in Lewis rats after elimination of macrophages.

I. Huitinga;N. Van Rooijen;C. J. A. De Groot;B. M. J. Uitdehaag.
Journal of Experimental Medicine (1990)

593 Citations

Alveolar macrophage elimination in vivo is associated with an increase in pulmonary immune response in mice.

T Thepen;N Van Rooijen;G Kraal.
Journal of Experimental Medicine (1989)

509 Citations

Immune Invasion of the Central Nervous System Parenchyma and Experimental Allergic Encephalomyelitis, But Not Leukocyte Extravasation from Blood, Are Prevented in Macrophage-Depleted Mice

E H Tran;K Hoekstra;N van Rooijen;C D Dijkstra.
Journal of Immunology (1998)

471 Citations

Apoptosis of macrophages induced by liposome-mediated intracellular delivery of clodronate and propamidine

N van Rooijen;A Sanders;T K van den Berg.
Journal of Immunological Methods (1996)

440 Citations

Gliomas induce and exploit microglial MT1-MMP expression for tumor expansion.

D.S. Markovic;K. Vinnakota;S. Chirasani;M. Synowitz.
Proceedings of the National Academy of Sciences of the United States of America (2009)

383 Citations

Depletion and repopulation of macrophages in spleen and liver of rat after intravenous treatment with liposome-encapsulated dichloromethylene diphosphonate.

N. Van Rooijen;N. Kors;M. v. d. Ende;C. D. Dijkstra.
Cell and Tissue Research (1990)

365 Citations

Elimination of phagocytic cells in the spleen after intravenous injection of liposome-encapsulated dichloromethylene diphosphonate. An enzyme-histochemical study.

N van Rooijen;R van Nieuwmegen.
Cell and Tissue Research (1984)

352 Citations

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