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Maureane Hoffman

Maureane Hoffman

Duke University
United States

Overview

What is he best known for?

The fields of study he is best known for:

  • Internal medicine
  • Enzyme
  • Platelet

The scientist’s investigation covers issues in Thrombin, Coagulation, Platelet, Internal medicine and Tissue factor. His study in Thrombin is interdisciplinary in nature, drawing from both Platelet activation, Biophysics, Biochemistry and Surgery. His studies in Coagulation integrate themes in fields like Phosphatidylserine and Intensive care medicine.

His work carried out in the field of Platelet brings together such families of science as Hypothermia, Anesthesia, Pathology, Enzyme and Hemostasis. He interconnects Endocrinology and Fibrin in the investigation of issues within Internal medicine. The study incorporates disciplines such as Antithrombin, Factor X, Factor IXa, Cell biology and Prothrombinase in addition to Tissue factor.

His most cited work include:

  • A cell-based model of hemostasis (1055 citations)
  • Platelets and Thrombin Generation (514 citations)
  • Platelet activity of high‐dose factor VIIa is independent of tissue factor (499 citations)

What are the main themes of his work throughout his whole career to date?

Maureane Hoffman mainly focuses on Coagulation, Thrombin, Platelet, Tissue factor and Internal medicine. His Coagulation research integrates issues from Factor IX, Immunology, Hemostasis, Pharmacology and Prothrombinase. His Thrombin study combines topics in areas such as Biophysics, Biochemistry and Antithrombin.

His Platelet research is multidisciplinary, incorporating perspectives in Anesthesia and Phosphatidylserine. As part of one scientific family, Maureane Hoffman deals mainly with the area of Tissue factor, narrowing it down to issues related to the Factor X, and often Annexin. Maureane Hoffman has researched Internal medicine in several fields, including Gastroenterology, Endocrinology and Fibrin.

He most often published in these fields:

  • Coagulation (48.70%)
  • Thrombin (47.21%)
  • Platelet (42.38%)

What were the highlights of his more recent work (between 2016-2020)?

  • Hemostasis (32.34%)
  • Cell biology (17.84%)
  • Tissue factor (39.78%)

In recent papers he was focusing on the following fields of study:

His scientific interests lie mostly in Hemostasis, Cell biology, Tissue factor, Platelet and Coagulation. The study incorporates disciplines such as Wound healing, Thrombosis and Thrombin in addition to Hemostasis. Thrombin is a primary field of his research addressed under Immunology.

His Tissue factor study deals with Protein C intersecting with Immunoprecipitation and Endothelial protein C receptor. His Platelet study focuses on Platelet activation in particular. The concepts of his Coagulation study are interwoven with issues in Kallikrein, Prothrombinase and Trypsin.

Between 2016 and 2020, his most popular works were:

  • Abnormal joint and bone wound healing in hemophilia mice is improved by extending factor IX activity after hemarthrosis (31 citations)
  • Preclinical Development of a vWF Aptamer to Limit Thrombosis and Engender Arterial Recanalization of Occluded Vessels. (16 citations)
  • Red blood cell microvesicles activate the contact system, leading to factor IX activation via 2 independent pathways. (15 citations)

In his most recent research, the most cited papers focused on:

  • Internal medicine
  • Enzyme
  • Platelet

Maureane Hoffman mostly deals with Coagulation, Hemostasis, Platelet, Cell biology and Tissue factor. His Coagulation research includes themes of Prekallikrein and Blood coagulation test. The Hemostasis study combines topics in areas such as Inflammation, Wound healing and Thrombin.

His Thrombin research entails a greater understanding of Immunology. His Platelet study is concerned with the larger field of Internal medicine. The various areas that Maureane Hoffman examines in his Tissue factor study include Cell signaling, Immunoprecipitation, Endothelial protein C receptor, Platelet activation and Protein C.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

A cell-based model of hemostasis

Maureane Hoffman;Dougald M. Monroe.
Thrombosis and Haemostasis (2001)

1701 Citations

Platelets and Thrombin Generation

Dougald M. Monroe;Maureane Hoffman;Harold R. Roberts.
Arteriosclerosis, Thrombosis, and Vascular Biology (2002)

754 Citations

Platelet activity of high‐dose factor VIIa is independent of tissue factor

Dougald M. Monroe;Maureane Hoffman;Julie A. Oliver;Harold R. Roberts.
British Journal of Haematology (1997)

680 Citations

Platelet functions beyond hemostasis

S. S. Smyth;R. P. Mcever;A. S. Weyrich;C. N. Morrell.
Journal of Thrombosis and Haemostasis (2009)

596 Citations

The effect of temperature and pH on the activity of factor VIIa: implications for the efficacy of high-dose factor VIIa in hypothermic and acidotic patients

Zhi Hong Meng;Alisa S. Wolberg;Dougald M. Monroe;Maureane Hoffman.
Journal of Trauma-injury Infection and Critical Care (2003)

574 Citations

A systematic evaluation of the effect of temperature on coagulation enzyme activity and platelet function

Alisa S. Wolberg;Zhi Hong Meng;Dougald M. Monroe;Maureane Hoffman.
Journal of Trauma-injury Infection and Critical Care (2004)

530 Citations

Coagulation disorders and hemostasis in liver disease: Pathophysiology and critical assessment of current management

Stephen H. Caldwell;Maureane Hoffman;Ton Lisman;B. Gail Macik.
Hepatology (2006)

499 Citations

What Does It Take to Make the Perfect Clot

Dougald M. Monroe;Maureane Hoffman.
Arteriosclerosis, Thrombosis, and Vascular Biology (2006)

435 Citations

A cell-based model of coagulation and the role of factor VIIa.

Maureane Hoffman.
Blood Reviews (2003)

429 Citations

Coagulation 2006: a modern view of hemostasis.

Maureane Hoffman;Maureane Hoffman;Dougald M. Monroe.
Hematology-oncology Clinics of North America (2007)

394 Citations

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