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Leendert H. J. Looijenga

Leendert H. J. Looijenga

Princess Maxima Center for Pediatric Oncology
Netherlands

Overview

What is he best known for?

The fields of study he is best known for:

  • Gene
  • Cancer
  • Internal medicine

His primary scientific interests are in Pathology, Cancer research, Germ cell, Seminoma and Embryonal carcinoma. The concepts of his Pathology study are interwoven with issues in Gonadoblastoma, Internal medicine and Intratubular germ cell neoplasia. His work deals with themes such as Chromatin, Transcription factor, Gene, Oncogene and Germ cell tumors, which intersect with Cancer research.

His Germ cell research is multidisciplinary, incorporating elements of Molecular biology, Stem cell marker and Somatic cell. His Seminoma study is focused on Genetics in general. His work carried out in the field of Embryonal carcinoma brings together such families of science as Stem cell and Teratoma.

His most cited work include:

  • Patterns of somatic mutation in human cancer genomes (2497 citations)
  • A Genetic Screen Implicates miRNA-372 and miRNA-373 As Oncogenes in Testicular Germ Cell Tumors (1072 citations)
  • Testicular germ-cell tumours in a broader perspective. (654 citations)

What are the main themes of his work throughout his whole career to date?

Leendert H. J. Looijenga spends much of his time researching Cancer research, Pathology, Germ cell tumors, Germ cell and Internal medicine. His studies in Cancer research integrate themes in fields like Cancer, Cisplatin, Somatic cell, Immunology and microRNA. In his research on the topic of Pathology, Embryonal carcinoma and Germinoma is strongly related with Seminoma.

His Germ cell tumors study integrates concerns from other disciplines, such as Testicular cancer and Teratoma. His Germ cell research incorporates elements of Molecular biology, Embryonic stem cell, Gonadoblastoma and Cell biology. His Internal medicine study incorporates themes from Gastroenterology, Endocrinology and Oncology.

He most often published in these fields:

  • Cancer research (30.05%)
  • Pathology (27.23%)
  • Germ cell tumors (24.18%)

What were the highlights of his more recent work (between 2017-2021)?

  • Cancer research (30.05%)
  • Internal medicine (22.30%)
  • Germ cell tumors (24.18%)

In recent papers he was focusing on the following fields of study:

The scientist’s investigation covers issues in Cancer research, Internal medicine, Germ cell tumors, Oncology and microRNA. His Cancer research research integrates issues from Cisplatin, DNA methylation, Embryonal carcinoma, Cancer stem cell and Germ cell. His Germ cell course of study focuses on Epigenetics and Stem cell.

The various areas that Leendert H. J. Looijenga examines in his Internal medicine study include Gastroenterology and Endocrinology. Leendert H. J. Looijenga works mostly in the field of Germ cell tumors, limiting it down to concerns involving Orchiectomy and, occasionally, Retroperitoneal lymph node dissection and Fibrosis. His Immunohistochemistry study necessitates a more in-depth grasp of Pathology.

Between 2017 and 2021, his most popular works were:

  • Genomic and Functional Approaches to Understanding Cancer Aneuploidy (296 citations)
  • Erratum: Comprehensive Characterization of Cancer Driver Genes and Mutations (ARTICLE (2018) 173(2) (371–385), (S009286741830237X), (10.1016/j.cell.2018.02.060)) (147 citations)
  • Pan-Cancer Analysis of lncRNA Regulation Supports Their Targeting of Cancer Genes in Each Tumor Context (125 citations)

In his most recent research, the most cited papers focused on:

  • Gene
  • Cancer
  • Internal medicine

Leendert H. J. Looijenga mainly investigates Cancer research, microRNA, Germ cell tumors, Gene and Intratubular germ cell neoplasia. His studies deal with areas such as DNA methylation, Somatic cell, Transcription factor, Oncogene and Chromatin as well as Cancer research. Leendert H. J. Looijenga interconnects Cancer, Lactate dehydrogenase, Testicular germ cell, Teratoma and Human chorionic gonadotropin in the investigation of issues within microRNA.

His Germ cell tumors research is multidisciplinary, incorporating perspectives in Liquid biopsy, Orchiectomy and Pathology. His Pathology research is multidisciplinary, relying on both Molecular pathology and Seminoma, Testicular Germ Cell Tumor. Leendert H. J. Looijenga has included themes like Embryonal carcinoma and Gene duplication in his Intratubular germ cell neoplasia study.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

Patterns of somatic mutation in human cancer genomes

Christopher Greenman;Philip Stephens;Raffaella Smith;Gillian L. Dalgliesh.
Nature (2007)

3469 Citations

Testicular germ-cell tumours in a broader perspective.

J. Wolter Oosterhuis;Leendert H. J. Looijenga.
Nature Reviews Cancer (2005)

938 Citations

POU5F1 (OCT3/4) Identifies Cells with Pluripotent Potential in Human Germ Cell Tumors

Leendert H. J. Looijenga;Hans Stoop;Hubert P. J. C. de Leeuw;Carlos A. de Gouveia Brazao.
Cancer Research (2003)

775 Citations

Lung cancer: intragenic ERBB2 kinase mutations in tumours.

Philip Stephens;Chris Hunter;Graham Bignell;Sarah Edkins.
Nature (2004)

754 Citations

Global Disorders of Sex Development Update since 2006: Perceptions, Approach and Care

Peter A. Lee;Anna Nordenström;Christopher P. Houk;S. Faisal Ahmed.
Hormone Research in Paediatrics (2016)

583 Citations

Genomic and Functional Approaches to Understanding Cancer Aneuploidy

Alison M. Taylor;Alison M. Taylor;Juliann Shih;Gavin Ha;Gavin Ha;Galen F. Gao.
Cancer Cell (2018)

562 Citations

Somatic Mutations of the Protein Kinase Gene Family in Human Lung Cancer

Helen Davies;Chris Hunter;Raffaella Smith;Philip Stephens.
Cancer Research (2005)

553 Citations

National Academy of Clinical Biochemistry Laboratory Medicine Practice Guidelines for Use of Tumor Markers in Testicular, Prostate, Colorectal, Breast, and Ovarian Cancers

Catharine M. Sturgeon;Michael J. Duffy;Ulf Håkan Stenman;Hans Lilja.
Clinical Chemistry (2008)

491 Citations

Germ cell tumors in the intersex gonad: old paths, new directions, moving frontiers.

Martine Cools;Stenvert L. S. Drop;Katja P. Wolffenbuttel;J. Wolter Oosterhuis.
Endocrine Reviews (2006)

488 Citations

A screen of the complete protein kinase gene family identifies diverse patterns of somatic mutations in human breast cancer

Philip Stephens;Sarah Edkins;Helen Davies;Christopher Greenman.
Nature Genetics (2005)

406 Citations

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