University of Cambridge
Kate Downes mainly focuses on Genetics, Genome-wide association study, Single-nucleotide polymorphism, Genetic association and Disease. Her study in Genetics is interdisciplinary in nature, drawing from both Hemodynamics and Type 1 diabetes. Genome-wide association study is a subfield of Gene that Kate Downes explores.
Her study looks at the relationship between Single-nucleotide polymorphism and topics such as Allele frequency, which overlap with Population stratification, Human genetics, CDKN2BAS, SNP and Diabetes mellitus genetics. Kate Downes combines subjects such as Genetic predisposition and Copy-number variation with her study of Genetic association. Her Disease research is multidisciplinary, relying on both Diabetes mellitus and Genetic linkage.
Genetics, Gene, Genome-wide association study, Epigenetics and Internal medicine are her primary areas of study. Her Genetics research focuses on subjects like Immunology, which are linked to Disease and Megakaryocyte. The Gene study which covers Computational biology that intersects with RNA and Gene expression.
Her Genome-wide association study study frequently draws parallels with other fields, such as Locus. Her research integrates issues of Epigenomics, DNA methylation and Immune system in her study of Epigenetics. As part of the same scientific family, Kate Downes usually focuses on Single-nucleotide polymorphism, concentrating on Type 1 diabetes and intersecting with Case-control study.
Kate Downes mainly investigates Internal medicine, Platelet, Epigenetics, Computational biology and Phenotype. Her research investigates the connection with Epigenetics and areas like Transcriptome which intersect with concerns in Megakaryocyte and Cell biology. Her Computational biology study combines topics from a wide range of disciplines, such as RNA, Gene, Blood cell, Cell type and Genetic testing.
Her study on Cell type also encompasses disciplines like
Kate Downes mostly deals with Internal medicine, Platelet disorder, Immunology, Desmopressin and Large cohort. The study incorporates disciplines such as Genetic variants and DNA sequencing in addition to Internal medicine. Her Platelet disorder research incorporates themes from Intensive care medicine and Inherited Coagulation Disorders.
In the subject of general Immunology, her work in Immune dysregulation, Immune system and Gray platelet syndrome is often linked to Autoantibody, thereby combining diverse domains of study. Her research in Immune dysregulation intersects with topics in Penetrance, Primary immunodeficiency, Haploinsufficiency and Immunodeficiency. Her studies deal with areas such as Clinical trial and Thromboelastometry as well as Desmopressin.
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Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls
Paul R. Burton;David G. Clayton;Lon R. Cardon;Nick Craddock.
Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes.
John A. Todd;Neil M. Walker;Jason D. Cooper;Deborah J. Smyth.
Nature Genetics (2007)
Genome-wide association study identifies eight loci associated with blood pressure
Christopher Newton-Cheh;Christopher Newton-Cheh;Toby Johnson;Toby Johnson;Vesela Gateva;Martin D. Tobin.
Nature Genetics (2009)
Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants
Paul R Burton;David G Clayton;Lon R Cardon;Nick Craddock.
Nature Genetics (2007)
Epigenetic programming of monocyte-to-macrophage differentiation and trained innate immunity
Sadia Saeed;Jessica Quintin;Hindrik H. D. Kerstens;Nagesha A. Rao.
The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease
William J. Astle;Heather Elding;Heather Elding;Tao Jiang;Dave Allen.
Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls
Nick Craddock;Matthew E. Hurles;Niall Cardin;Richard D. Pearson.
Shared and distinct genetic variants in type 1 diabetes and celiac disease.
Deborah J. Smyth;Vincent Plagnol;Neil M. Walker;Jason D. Cooper.
The New England Journal of Medicine (2008)
Lineage-Specific Genome Architecture Links Enhancers and Non-coding Disease Variants to Target Gene Promoters
Biola M Javierre;Oliver S Burren;Steven P Wilder;Roman Kreuzhuber.
Localization of type 1 diabetes susceptibility to the MHC class I genes HLA-B and HLA-A
Sergey Nejentsev;Joanna M. M. Howson;Neil M. Walker;Jeffrey Szeszko.
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