D-Index & Metrics Best Publications

D-Index & Metrics D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines.

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Biology and Biochemistry D-index 66 Citations 12,765 134 World Ranking 5672 National Ranking 412

Overview

What is he best known for?

The fields of study he is best known for:

  • Enzyme
  • Gene
  • Amino acid

K von Figura focuses on Biochemistry, Mannose 6-phosphate receptor, Cell biology, Mannose and Cathepsin D. Biochemistry is closely attributed to Molecular biology in his work. The study incorporates disciplines such as Receptor and Mannose 6-phosphate in addition to Mannose 6-phosphate receptor.

His research integrates issues of Osteopetrosis, Transmembrane protein, Transmembrane domain, Immunoelectron microscopy and Clathrin adaptor proteins in his study of Cell biology. His work deals with themes such as Secretion, Transferrin and Enzyme, which intersect with Mannose. His study looks at the relationship between Cathepsin D and topics such as Cathepsin, which overlap with Glycosylation.

His most cited work include:

  • Lysosomal Enzymes and their Receptors (797 citations)
  • Mice deficient for the lysosomal proteinase cathepsin D exhibit progressive atrophy of the intestinal mucosa and profound destruction of lymphoid cells. (370 citations)
  • Carbohydrate-deficient glycoprotein syndrome type Ib. Phosphomannose isomerase deficiency and mannose therapy. (340 citations)

What are the main themes of his work throughout his whole career to date?

His primary scientific interests are in Biochemistry, Mannose, Molecular biology, Mannose 6-phosphate receptor and Receptor. His study connects Cell biology and Biochemistry. In his study, Site-directed mutagenesis is strongly linked to Glycosylation, which falls under the umbrella field of Mannose.

The Molecular biology study combines topics in areas such as Gene expression, Mucopolysaccharidosis type VI, Mutation, Peptide sequence and Arylsulfatase B. His Mannose 6-phosphate receptor study contributes to a more complete understanding of Lysosome. His Lysosome study combines topics from a wide range of disciplines, such as Lysosomal acid phosphatase and Acid phosphatase.

He most often published in these fields:

  • Biochemistry (64.23%)
  • Mannose (29.93%)
  • Molecular biology (29.93%)

What were the highlights of his more recent work (between 1996-2006)?

  • Biochemistry (64.23%)
  • Mannose (29.93%)
  • Arylsulfatase A (13.87%)

In recent papers he was focusing on the following fields of study:

The scientist’s investigation covers issues in Biochemistry, Mannose, Arylsulfatase A, Receptor and Formylglycine-generating enzyme. His study ties his expertise on Molecular biology together with the subject of Biochemistry. His research investigates the link between Molecular biology and topics such as Tartrate-resistant acid phosphatase that cross with problems in Bone resorption.

His study in Mannose is interdisciplinary in nature, drawing from both Endosome, Glycoprotein and Enzyme. The concepts of his Arylsulfatase A study are interwoven with issues in Cysteine, Mutant and Active site. His studies in Formylglycine-generating enzyme integrate themes in fields like Arylsulfatases, Hydrolase, Sulfation, Aldehyde and Stereochemistry.

Between 1996 and 2006, his most popular works were:

  • Carbohydrate-deficient glycoprotein syndrome type Ib. Phosphomannose isomerase deficiency and mannose therapy. (340 citations)
  • Crystal structure of human arylsulfatase A: the aldehyde function and the metal ion at the active site suggest a novel mechanism for sulfate ester hydrolysis. (297 citations)
  • A di-leucine-based motif in the cytoplasmic tail of LIMP-II and tyrosinase mediates selective binding of AP-3 (270 citations)

In his most recent research, the most cited papers focused on:

  • Enzyme
  • Gene
  • Amino acid

His primary areas of study are Biochemistry, Cell biology, Mannose, Stereochemistry and Transferrin. Biochemistry is often connected to Molecular biology in his work. His Cell biology study incorporates themes from Monomeric Clathrin Assembly Proteins, Vesicular transport protein and Clathrin.

K von Figura combines subjects such as Cathepsin D, Cathepsin, Mannose 6-phosphate receptor, Receptor and Intracellular with his study of Mannose. His research on Stereochemistry also deals with topics like

  • Hydrolase and related Sulfation, Enzyme substrate complex, Histidine, Arylsulfatase A and Cysteine,
  • Formylglycine-generating enzyme, which have a strong connection to Active site and Aldehyde. His research in Transferrin intersects with topics in Enteropathy, Congenital disorder of glycosylation and Phosphomannomutase, Glycoprotein.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

Lysosomal Enzymes and their Receptors

K von Figura;A Hasilik.
Annual Review of Biochemistry (1986)

1121 Citations

Mice deficient for the lysosomal proteinase cathepsin D exhibit progressive atrophy of the intestinal mucosa and profound destruction of lymphoid cells.

P. Saftig;M. Hetman;W. Schmahl;K. Weber.
The EMBO Journal (1995)

484 Citations

Carbohydrate-deficient glycoprotein syndrome type Ib. Phosphomannose isomerase deficiency and mannose therapy.

R. Niehues;M. Hasilik;G. Alton;C. Korner.
Journal of Clinical Investigation (1998)

472 Citations

A di-leucine-based motif in the cytoplasmic tail of LIMP-II and tyrosinase mediates selective binding of AP-3

S Höning;I V Sandoval;K von Figura.
The EMBO Journal (1998)

411 Citations

Crystal structure of human arylsulfatase A: the aldehyde function and the metal ion at the active site suggest a novel mechanism for sulfate ester hydrolysis.

G Lukatela;N Krauss;K Theis;T Selmer.
Biochemistry (1998)

380 Citations

Molecular Basis of Different Forms of Metachromatic Leukodystrophy

A Polten;A L Fluharty;C B Fluharty;J Kappler.
The New England Journal of Medicine (1991)

346 Citations

Biosynthesis and transport of cathepsin D in cultured human fibroblasts.

V Gieselmann;R Pohlmann;A Hasilik;K Von Figura.
Journal of Cell Biology (1983)

281 Citations

Possible pathways for lysosomal enzyme delivery

H. J. Geuze;J. W. Slot;G. J. A. M. Strous;A. Hasilik.
Journal of Cell Biology (1985)

279 Citations

Arylsulfatase A pseudodeficiency: loss of a polyadenylylation signal and N-glycosylation site

V Gieselmann;A Polten;J Kreysing;K von Figura.
Proceedings of the National Academy of Sciences of the United States of America (1989)

274 Citations

Targeting of a lysosomal membrane protein: a tyrosine-containing endocytosis signal in the cytoplasmic tail of lysosomal acid phosphatase is necessary and sufficient for targeting to lysosomes.

C Peters;M Braun;B Weber;M Wendland.
The EMBO Journal (1990)

248 Citations

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