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Helen Skaletsky

Helen Skaletsky

MIT
United States

Overview

What is she best known for?

The fields of study she is best known for:

  • Gene
  • DNA
  • Genetics

Helen Skaletsky mainly investigates Genetics, Y chromosome, Gene, Azoospermia factor and Y chromosome microdeletion. Her Genetics study is mostly concerned with Embryonic stem cell, Chromosome, Heterochromatin and Y linkage. Her study in Y chromosome is interdisciplinary in nature, drawing from both Gene family, BPY2, X chromosome, Gene duplication and Palindrome.

The concepts of her BPY2 study are interwoven with issues in Chromosomal inversion, Direct repeat, Euchromatin, Tandem exon duplication and Physical Chromosome Mapping. Her Embryo research extends to the thematically linked field of Gene. Her study explores the link between Y chromosome microdeletion and topics such as Homologous recombination that cross with problems in Ploidy, Polymorphism, Breakpoint and Homology.

Her most cited work include:

  • Primer3 on the WWW for general users and for biologist programmers. (13931 citations)
  • The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes. (1694 citations)
  • The AZFc region of the Y chromosome features massive palindromes and uniform recurrent deletions in infertile men. (571 citations)

What are the main themes of her work throughout her whole career to date?

Her primary areas of investigation include Genetics, Y chromosome, Gene, X chromosome and Evolutionary biology. Her study in Autosome, Chromosome, Chimpanzee genome project, Homologous recombination and Genome falls within the category of Genetics. Her Genome research is multidisciplinary, incorporating perspectives in Computational biology, Haplotype and Sequence.

Her Y chromosome research is multidisciplinary, incorporating elements of Lineage, Sequence-tagged site, Azoospermia factor, Gene duplication and Spermatogenic failure. Her X chromosome research focuses on Palindrome and how it connects with Gene conversion. In her research on the topic of Evolutionary biology, New World monkey and Callithrix is strongly related with Phylogenetics.

She most often published in these fields:

  • Genetics (119.78%)
  • Y chromosome (96.70%)
  • Gene (63.74%)

What were the highlights of her more recent work (between 2017-2021)?

  • Y chromosome (96.70%)
  • Evolutionary biology (26.37%)
  • Gene (63.74%)

In recent papers she was focusing on the following fields of study:

Helen Skaletsky mainly focuses on Y chromosome, Evolutionary biology, Gene, X chromosome and Genome. Y chromosome is a subfield of Genetics that she explores. Her work on Regulatory sequence and Regulator gene is typically connected to Initiation factor, Eukaryotic translation and EIF1AX as part of general Gene study, connecting several disciplines of science.

She combines subjects such as Sequence, Rhesus macaque, Palindrome and Gene family with her study of X chromosome. Her research in Gene family intersects with topics in Gene duplication, Convergent evolution, Sequence analysis and Evolution of mammals. In general Genome study, her work on Bacterial artificial chromosome and Fosmid often relates to the realm of Barcode and Throughput, thereby connecting several areas of interest.

Between 2017 and 2021, her most popular works were:

  • Selection Has Countered High Mutability to Preserve the Ancestral Copy Number of Y Chromosome Amplicons in Diverse Human Lineages. (17 citations)
  • Selection Has Countered High Mutability to Preserve the Ancestral Copy Number of Y Chromosome Amplicons in Diverse Human Lineages. (17 citations)
  • Quantitative analysis of Y-Chromosome gene expression across 36 human tissues (6 citations)

In her most recent research, the most cited papers focused on:

  • Gene
  • DNA
  • Chromosome

Y chromosome, 1000 Genomes Project, Phylogenetics, Amplicon and Phylogenetic tree are her primary areas of study. Helen Skaletsky integrates many fields in her works, including Y chromosome and Initiation factor. Among her Initiation factor studies, there is a synthesis of other scientific areas such as Gene, Eukaryotic translation, EIF1AX, Regulatory sequence and Regulator gene.

Her Gene study introduces a deeper knowledge of Genetics. Throughout her 1000 Genomes Project studies, Helen Skaletsky incorporates elements of other sciences such as Copy-number variation, Haplogroup, Neutral theory of molecular evolution and Evolutionary biology.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

Primer3 on the WWW for general users and for biologist programmers.

Steve Rozen;Helen Skaletsky.
Methods of Molecular Biology (2000)

18890 Citations

The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes.

Helen Skaletsky;Tomoko Kuroda-Kawaguchi;Patrick J. Minx;Holland S. Cordum.
Nature (2003)

2417 Citations

The AZFc region of the Y chromosome features massive palindromes and uniform recurrent deletions in infertile men.

Tomoko Kuroda-Kawaguchi;Helen Skaletsky;Helen Skaletsky;Laura G. Brown;Laura G. Brown;Patrick J. Minx.
Nature Genetics (2001)

821 Citations

Abundant gene conversion between arms of palindromes in human and ape Y chromosomes

Steve Rozen;Helen Skaletsky;Janet D. Marszalek;Patrick J. Minx.
Nature (2003)

720 Citations

Incomplete reactivation of Oct4-related genes in mouse embryos cloned from somatic nuclei.

Alex Bortvin;Kevin Eggan;Helen Skaletsky;Helen Skaletsky;Hidenori Akutsu.
Development (2003)

569 Citations

Recombination between palindromes P5 and P1 on the human Y chromosome causes massive deletions and spermatogenic failure.

Sjoerd Repping;Sjoerd Repping;Helen Skaletsky;Julian Lange;Sherman Silber.
American Journal of Human Genetics (2002)

554 Citations

The DAZ gene cluster on the human Y chromosome arose from an autosomal gene that was transposed, repeatedly amplified and pruned

Richa Saxena;Laura G. Brown;Trevor Hawkins;Raaji K. Alagappan.
Nature Genetics (1996)

538 Citations

Polymorphism for a 1.6-Mb deletion of the human Y chromosome persists through balance between recurrent mutation and haploid selection.

Sjoerd Repping;Helen Skaletsky;Laura Brown;Saskia K M van Daalen.
Nature Genetics (2003)

517 Citations

Mammalian Y chromosomes retain widely expressed dosage-sensitive regulators

Daniel W. Bellott;Jennifer F. Hughes;Helen Skaletsky;Laura G. Brown.
Nature (2014)

515 Citations

An azoospermic man with a de novo point mutation in the Y-chromosomal gene USP9Y

Chao Sun;Chao Sun;Helen Skaletsky;Helen Skaletsky;Bruce Birren;Keri Devon.
Nature Genetics (1999)

458 Citations

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