D-Index & Metrics Best Publications
David R. Sibley

David R. Sibley

National Institutes of Health
United States

Overview

What is he best known for?

The fields of study he is best known for:

  • Gene
  • DNA
  • Receptor

David R. Sibley mainly focuses on Receptor, Dopamine receptor, Internal medicine, Endocrinology and Molecular biology. David R. Sibley has researched Receptor in several fields, including Neuroscience and Cell biology. His research integrates issues of Dopaminergic and Dopamine receptor D2 in his study of Dopamine receptor.

His Dopamine receptor D2 research is within the category of Dopamine. His research in Internal medicine focuses on subjects like Pharmacology, which are connected to Tiospirone, Fluperlapine, Atypical antipsychotic and Zotepine. His Molecular biology research is multidisciplinary, incorporating elements of 5-HT5A receptor, Chinese hamster ovary cell, 5-HT6 receptor, Complementary DNA and Enzyme-linked receptor.

His most cited work include:

  • D1 and D2 dopamine receptor-regulated gene expression of striatonigral and striatopallidal neurons (2527 citations)
  • Molecular biology of dopamine receptors. (879 citations)
  • Aripiprazole, a novel atypical antipsychotic drug with a unique and robust pharmacology. (743 citations)

What are the main themes of his work throughout his whole career to date?

His scientific interests lie mostly in Dopamine receptor, Receptor, Dopamine receptor D2, Internal medicine and Endocrinology. The various areas that David R. Sibley examines in his Dopamine receptor study include Agonist, Dopaminergic and Pharmacology. His studies deal with areas such as Molecular biology, Dopamine and Phosphorylation, Cell biology as well as Receptor.

His work in Molecular biology tackles topics such as 5-HT5A receptor which are related to areas like Interleukin-21 receptor. Many of his studies involve connections with topics such as G protein-coupled receptor and Dopamine receptor D2. His Endocrinology study focuses on Striatum in particular.

He most often published in these fields:

  • Dopamine receptor (52.73%)
  • Receptor (50.55%)
  • Dopamine receptor D2 (32.73%)

What were the highlights of his more recent work (between 2017-2021)?

  • Dopamine receptor (52.73%)
  • Pharmacology (17.09%)
  • Dopamine receptor D2 (32.73%)

In recent papers he was focusing on the following fields of study:

His primary areas of investigation include Dopamine receptor, Pharmacology, Dopamine receptor D2, Dopamine and Receptor. His Dopamine receptor study is concerned with the field of Neuroscience as a whole. The study incorporates disciplines such as Psychosis, Dopamine receptor antagonist, Allosteric regulation and Dopamine receptor D3 in addition to Pharmacology.

His studies in Dopamine receptor D2 integrate themes in fields like Arrestin, Biophysics and Structure–activity relationship. His work on Antagonist as part of general Receptor study is frequently linked to Glucagon, bridging the gap between disciplines. His work carried out in the field of Internal medicine brings together such families of science as Sedative and Endocrinology.

Between 2017 and 2021, his most popular works were:

  • High-potency ligands for DREADD imaging and activation in rodents and monkeys. (37 citations)
  • Advances and challenges in the search for D2 and D3 dopamine receptor-selective compounds. (23 citations)
  • New roles for dopamine D2 and D3 receptors in pancreatic beta cell insulin secretion. (19 citations)

In his most recent research, the most cited papers focused on:

  • Gene
  • DNA
  • Dopamine

The scientist’s investigation covers issues in Dopamine receptor D2, Dopamine, Agonist, Pharmacology and Dopamine receptor. His Dopamine receptor D2 study contributes to a more complete understanding of Endocrinology. Dopamine is closely attributed to Receptor in his work.

David R. Sibley focuses mostly in the field of Agonist, narrowing it down to topics relating to G protein and, in certain cases, Functional selectivity, Biophysics and Ligand. His Pharmacology research integrates issues from Partial agonist, Allosteric regulation, Substance use and Dopamine receptor D3. His Dopamine receptor research is under the purview of Neuroscience.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

D1 and D2 dopamine receptor-regulated gene expression of striatonigral and striatopallidal neurons

Charles R. Gerfen;Thomas M. Engber;Lawrence C. Mahan;Zvi Susel.
Science (1990)

3390 Citations

Molecular biology of dopamine receptors.

David R. Sibley;Frederick J. Monsma.
Trends in Pharmacological Sciences (1992)

1268 Citations

Aripiprazole, a novel atypical antipsychotic drug with a unique and robust pharmacology.

David A. Shapiro;Sean Renock;Elaine Arrington;Louis A. Chiodo.
Neuropsychopharmacology (2003)

1138 Citations

Molecular mechanisms of receptor desensitization using the β -adrenergic receptor-coupled adenylate cyclase system as a model

David R. Sibley;Robert J. Lefkowitz.
Nature (1985)

936 Citations

Binding of typical and atypical antipsychotic agents to 5-hydroxytryptamine-6 and 5-hydroxytryptamine-7 receptors.

B L Roth;S C Craigo;M S Choudhary;A Uluer.
Journal of Pharmacology and Experimental Therapeutics (1994)

914 Citations

Regulation of transmembrane signaling by receptor phosphorylation

David R. Sibley;Jeffrey L. Benovic;Marc G. Caron;Robert J. Lefkowitz.
Cell (1987)

892 Citations

Cloning and expression of a novel serotonin receptor with high affinity for tricyclic psychotropic drugs.

Frederick J. Monsma;Yong Shen;Raymond P. Ward;Mark W. Hamblin.
Molecular Pharmacology (1993)

879 Citations

Multiple D2 dopamine receptors produced by alternative RNA splicing.

Frederick J. Monsma;Loris D. McVittie;Charles R. Gerfen;Lawrence C. Mahan.
Nature (1989)

773 Citations

Molecular cloning and expression of a 5-hydroxytryptamine7 serotonin receptor subtype.

Yong Shen;Frederick J. Monsma;Mark A. Metcalf;Pedro A. Jose.
Journal of Biological Chemistry (1993)

664 Citations

Molecular cloning and expression of a D1 dopamine receptor linked to adenylyl cyclase activation

Frederick J. Monsma;Lawrence C. Mahan;Loris D. McVittie;Charles R. Gerfen.
Proceedings of the National Academy of Sciences of the United States of America (1990)

631 Citations

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