What is he best known for?
The fields of study he is best known for:
David M. Sabatini mainly investigates Cell biology, mTORC1, mTORC2, PI3K/AKT/mTOR pathway and Biochemistry.
His Genetics research extends to Cell biology, which is thematically connected.
His mTORC1 research includes themes of Mechanistic target of rapamycin and Lysosome.
His mTORC2 research is multidisciplinary, incorporating perspectives in TOR Serine-Threonine Kinases, TOR complex, DEPTOR and RPTOR.
His PI3K/AKT/mTOR pathway study integrates concerns from other disciplines, such as Autophagy, Cancer research, Neuroscience and Sirolimus.
As part of one scientific family, David M. Sabatini deals mainly with the area of Cancer research, narrowing it down to issues related to the Cancer, and often Pharmacology, Metabolism and Gene silencing.
His most cited work include:
- mTOR signaling in growth control and disease. (5400 citations)
- Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex (5215 citations)
- Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (4170 citations)
What are the main themes of his work throughout his whole career to date?
David M. Sabatini mainly focuses on Cell biology, mTORC1, PI3K/AKT/mTOR pathway, Biochemistry and Signal transduction.
His Cell biology research includes elements of Autophagy and Cell growth.
His biological study spans a wide range of topics, including Amino acid, Endocrinology, GTPase and Lysosome.
His PI3K/AKT/mTOR pathway research incorporates themes from Protein kinase B and Cancer research.
His Cancer research research focuses on Cancer and how it relates to Pharmacology.
His mTORC2 study combines topics from a wide range of disciplines, such as DEPTOR and TOR complex.
He most often published in these fields:
- Cell biology (51.26%)
- mTORC1 (37.18%)
- PI3K/AKT/mTOR pathway (33.61%)
What were the highlights of his more recent work (between 2017-2021)?
- Cell biology (51.26%)
- mTORC1 (37.18%)
- Cancer research (16.81%)
In recent papers he was focusing on the following fields of study:
His primary scientific interests are in Cell biology, mTORC1, Cancer research, PI3K/AKT/mTOR pathway and Serine.
The study incorporates disciplines such as Lysosome, In vivo and Metabolism in addition to Cell biology.
In his research on the topic of mTORC1, NPRL3 is strongly related with Amino acid.
His research in Cancer research intersects with topics in Cell culture, Programmed cell death, Cell growth and Cancer.
His work deals with themes such as Autophagy, Disease and Ageing, which intersect with PI3K/AKT/mTOR pathway.
Serine is a primary field of his research addressed under Biochemistry.
Between 2017 and 2021, his most popular works were:
- mTOR at the nexus of nutrition, growth, ageing and disease (277 citations)
- NUFIP1 is a ribosome receptor for starvation-induced ribophagy (143 citations)
- Histidine catabolism is a major determinant of methotrexate sensitivity. (107 citations)
In his most recent research, the most cited papers focused on:
David M. Sabatini focuses on Cell biology, mTORC1, GTPase, Autophagy and Serine.
Cell biology is frequently linked to Receptor in his study.
David M. Sabatini has researched mTORC1 in several fields, including Amino acid, Wnt signaling pathway and Lysosome.
The Lysosome study combines topics in areas such as Mechanistic target of rapamycin and Signal transduction.
His research integrates issues of Ubiquitin, Ubiquitin ligase, Ubiquitin binding and PI3K/AKT/mTOR pathway in his study of Autophagy.
His PI3K/AKT/mTOR pathway study combines topics in areas such as Cortical dysplasia, Neuroscience, Epilepsy and Conditional gene knockout.
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