2022 - Research.com Best Scientist Award
2019 - BBVA Foundation Frontiers of Knowledge Award
2019 - Louisa Gross Horwitz Prize, Columbia University
2017 - Lurie Prize in Biomedical Sciences, Foundation for the National Institutes of Health
2016 - Member of the National Academy of Sciences
2009 - Paul Marks Prize for Cancer Research, Memorial Sloan Kettering Cancer Center
David M. Sabatini mainly investigates Cell biology, mTORC1, mTORC2, PI3K/AKT/mTOR pathway and Biochemistry. His Genetics research extends to Cell biology, which is thematically connected. His mTORC1 research includes themes of Mechanistic target of rapamycin and Lysosome.
His mTORC2 research is multidisciplinary, incorporating perspectives in TOR Serine-Threonine Kinases, TOR complex, DEPTOR and RPTOR. His PI3K/AKT/mTOR pathway study integrates concerns from other disciplines, such as Autophagy, Cancer research, Neuroscience and Sirolimus. As part of one scientific family, David M. Sabatini deals mainly with the area of Cancer research, narrowing it down to issues related to the Cancer, and often Pharmacology, Metabolism and Gene silencing.
David M. Sabatini mainly focuses on Cell biology, mTORC1, PI3K/AKT/mTOR pathway, Biochemistry and Signal transduction. His Cell biology research includes elements of Autophagy and Cell growth. His biological study spans a wide range of topics, including Amino acid, Endocrinology, GTPase and Lysosome.
His PI3K/AKT/mTOR pathway research incorporates themes from Protein kinase B and Cancer research. His Cancer research research focuses on Cancer and how it relates to Pharmacology. His mTORC2 study combines topics from a wide range of disciplines, such as DEPTOR and TOR complex.
His primary scientific interests are in Cell biology, mTORC1, Cancer research, PI3K/AKT/mTOR pathway and Serine. The study incorporates disciplines such as Lysosome, In vivo and Metabolism in addition to Cell biology. In his research on the topic of mTORC1, NPRL3 is strongly related with Amino acid.
His research in Cancer research intersects with topics in Cell culture, Programmed cell death, Cell growth and Cancer. His work deals with themes such as Autophagy, Disease and Ageing, which intersect with PI3K/AKT/mTOR pathway. Serine is a primary field of his research addressed under Biochemistry.
David M. Sabatini focuses on Cell biology, mTORC1, GTPase, Autophagy and Serine. Cell biology is frequently linked to Receptor in his study. David M. Sabatini has researched mTORC1 in several fields, including Amino acid, Wnt signaling pathway and Lysosome.
The Lysosome study combines topics in areas such as Mechanistic target of rapamycin and Signal transduction. His research integrates issues of Ubiquitin, Ubiquitin ligase, Ubiquitin binding and PI3K/AKT/mTOR pathway in his study of Autophagy. His PI3K/AKT/mTOR pathway study combines topics in areas such as Cortical dysplasia, Neuroscience, Epilepsy and Conditional gene knockout.
This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.
Guidelines for the use and interpretation of assays for monitoring autophagy
Daniel J. Klionsky;Fabio C. Abdalla;Hagai Abeliovich;Robert T. Abraham.
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin.
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
David M. Sabatini;Dos D. Sarbassov.
mTOR signaling in growth control and disease.
Mathieu Laplante;David M. Sabatini.
CellProfiler: image analysis software for identifying and quantifying cell phenotypes
Anne E Carpenter;Thouis R Jones;Michael R Lamprecht;Colin Clarke.
Genome Biology (2006)
mTOR: from growth signal integration to cancer, diabetes and ageing
Roberto Zoncu;Alejo Efeyan;David M. Sabatini.
Nature Reviews Molecular Cell Biology (2011)
mTOR Signaling in Growth, Metabolism, and Disease.
Robert A. Saxton;David M. Sabatini.
mTOR Interacts with Raptor to Form a Nutrient-Sensitive Complex that Signals to the Cell Growth Machinery
Do Hyung Kim;Dos D. Sarbassov;Siraj M. Ali;Jessie E. King.
Defining the Role of mTOR in Cancer
David A. Guertin;David A. Guertin;David M. Sabatini;David M. Sabatini.
Cancer Cell (2007)
Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton.
Dos D. Sarbassov;Siraj M Ali;Do-Hyung Kim;David A Guertin.
Current Biology (2004)
If you think any of the details on this page are incorrect, let us know.
We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below: