Home
C.J.M. Melief

C.J.M. Melief

Leiden University Medical Center
Netherlands

Overview

What is he best known for?

The fields of study he is best known for:

Immune system
Gene
Antibody

C. J. M. Melief mostly deals with Immunotherapy, Cytotoxic T cell, Immunology, CTL* and Immune system. His Immunotherapy study is associated with Cancer. The study incorporates disciplines such as Major histocompatibility complex, Antigen, Molecular biology, Caspase 8 and Cell biology in addition to Cytotoxic T cell.

C. J. M. Melief does research in Immunology, focusing on Vaccination specifically. His CTL* study incorporates themes from Epitope and Immunity. His Epitope research includes themes of Tumor antigen and T-cell receptor.

His most cited work include:

Circumventing tolerance to a human MDM2-derived tumor antigen by TCR gene transfer. (375 citations)
Episialin (MUC1) inhibits cytotoxic lymphocyte-target cell interaction. (202 citations)
Enhanced tumor outgrowth after peptide vaccination. Functional deletion of tumor-specific CTL induced by peptide vaccination can lead to the inability to reject tumors. (190 citations)

What are the main themes of his work throughout his whole career to date?

C. J. M. Melief focuses on Immunology, Cytotoxic T cell, Virology, CTL* and Antigen. In his study, Clinical trial and General surgery is strongly linked to Cancer, which falls under the umbrella field of Immunology. His biological study spans a wide range of topics, including Fas receptor, Major histocompatibility complex and Cell biology.

The various areas that he examines in his Virology study include Human papillomavirus and Ctl epitope. His CTL* research incorporates themes from Epitope, Cellular immunity, Adoptive cell transfer and Viral vector. His work carried out in the field of Antigen brings together such families of science as Molecular biology, Internal medicine and Immunotherapy.

He most often published in these fields:

Immunology (38.81%)
Cytotoxic T cell (29.85%)
Virology (26.87%)

What were the highlights of his more recent work (between 2005-2017)?

Immunology (38.81%)
Cancer (11.94%)
Immunotherapy (17.91%)

In recent papers he was focusing on the following fields of study:

C. J. M. Melief mainly investigates Immunology, Cancer, Immunotherapy, Virology and Cytotoxic T cell. Cancer immunotherapy and Antigen are subfields of Immunology in which his conducts study. His Cancer research includes elements of Gynecology, General surgery and Vaccination.

C. J. M. Melief interconnects Predictive value of tests and Intensive care medicine in the investigation of issues within Immunotherapy. His study looks at the relationship between Virology and fields such as Human papillomavirus, as well as how they intersect with chemical problems. His study in Cytotoxic T cell is interdisciplinary in nature, drawing from both Epitope and Human leukocyte antigen.

Between 2005 and 2017, his most popular works were:

“MIATA”—Minimal Information about T Cell Assays (163 citations)
Defining the critical hurdles in cancer immunotherapy (132 citations)
Identification of T-cell epitopes for cancer immunotherapy (114 citations)

In his most recent research, the most cited papers focused on:

Immune system
Gene
Cancer

His primary areas of study are Immunology, Immunotherapy, In patient, Cancer and Cancer immunotherapy. T cell response is the focus of his Immunology research. C. J. M. Melief combines subjects such as Viral Vaccine and Vaccination with his study of T cell response.

He has researched Computational biology in several fields, including Epitope, Human leukocyte antigen, Antigen, Transporter associated with antigen processing and Cytotoxic T cell. Specifically, his work in Cytotoxic T cell is concerned with the study of Antigen processing. In his papers, he integrates diverse fields, such as Medical practice and Data science.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

Circumventing tolerance to a human MDM2-derived tumor antigen by TCR gene transfer.

Thomas Stanislawski;Ralf-Holger Voss;Carina Lotz;Elena Sadovnikova.
Nature Immunology (2001)

470 Citations

Immune escape of tumors in vivo by expression of cellular FLICE-inhibitory protein.

J. P. Medema;J. De Jong;T. Van Hall;C. J. M. Melief.
Journal of Experimental Medicine (1999)

425 Citations

Blockade of the granzyme B/perforin pathway through overexpression of the serine protease inhibitor PI-9/SPI-6 constitutes a mechanism for immune escape by tumors

J. P. Medema;J. de Jong;L. T. C. Peltenburg;E. M. E. Verdegaal.
Proceedings of the National Academy of Sciences of the United States of America (2001)

400 Citations

Episialin (MUC1) inhibits cytotoxic lymphocyte-target cell interaction.

E. van de Wiel-van Kemenade;M.J.L. Ligtenberg;A.J. de Boer;F. Buijs.
Journal of Immunology (1993)

306 Citations

Enhanced tumor outgrowth after peptide vaccination. Functional deletion of tumor-specific CTL induced by peptide vaccination can lead to the inability to reject tumors.

R. E. M. Toes;R. J. J. Blom;R. Offringa;W. M. Kast.
Journal of Immunology (1996)

288 Citations

Identification of peptide sequences that potentially trigger HLA-A2.1-restricted cytotoxic T lymphocytes

H. W. Nijman;J. G. A. Houbiers;M. P. M. Vierboom;S. H. Van Der Burg.
European Journal of Immunology (1993)

268 Citations

Allele-specific differences in the interaction of MHC class I molecules with transporters associated with antigen processing.

A. Neisig;R. Wubbolts;Xiaosong Zang;C. Melief.
Journal of Immunology (1996)

249 Citations

Decreased expression of signal-transducing zeta chain in peripheral T cells and natural killer cells in patients with cervical cancer.

K. Kono;M. E. Ressing;R. M. P. Brandt;C. J. M. Melief.
Clinical Cancer Research (1996)

246 Citations

Antigen capture and major histocompatibility class II compartments of freshly isolated and cultured human blood dendritic cells.

H. W. Nijman;M. J. Kleijmeer;M. A. Ossevoort;V. M. J. Oorschot.
Journal of Experimental Medicine (1995)

239 Citations

Molecular Mimicry of Human Cytochrome P450 by Hepatitis C Virus at the Level of Cytotoxic T Cell Recognition

A. R. Kammer;S. H. Van Der Burg;B. Grabscheid;I. P. Hunziker.
Journal of Experimental Medicine (1999)

226 Citations

If you think any of the details on this page are incorrect, let us know.