D-Index & Metrics Best Publications
Carl D. Novina

Carl D. Novina

Harvard University
United States

Research.com Recognitions

Awards & Achievements

2014 - National Institutes of Health Director's Pioneer Award

Overview

What is he best known for?

The fields of study he is best known for:

  • Gene
  • DNA
  • Gene expression

Cell biology, Gene silencing, Transcription factor, Genetics and RNA interference are his primary areas of study. His research investigates the connection between Cell biology and topics such as Molecular biology that intersect with issues in AP site. The concepts of his Gene silencing study are interwoven with issues in Gene knockdown, Virology, Trans-acting siRNA, Messenger RNA and microRNA.

His work carried out in the field of Trans-acting siRNA brings together such families of science as DNA-directed RNA interference and Argonaute. His Transcription factor research is multidisciplinary, relying on both Transcription and Morphology. His study in the field of RNA silencing also crosses realms of Natural phenomenon.

His most cited work include:

  • Killing the messenger: short RNAs that silence gene expression (1110 citations)
  • Lentivirus-delivered stable gene silencing by RNAi in primary cells. (965 citations)
  • siRNA-directed inhibition of HIV-1 infection (787 citations)

What are the main themes of his work throughout his whole career to date?

Carl D. Novina mainly focuses on Cancer research, Cell biology, microRNA, Genetics and Molecular biology. Carl D. Novina combines subjects such as Haematopoiesis, Immunology, Bone marrow and Gene knockdown with his study of Cancer research. His Cell biology study integrates concerns from other disciplines, such as RNA, Psychological repression, Transcription and Argonaute.

His microRNA research is multidisciplinary, incorporating perspectives in Protein kinase B, Gene expression profiling, P-bodies, Protein biosynthesis and Messenger RNA. His research investigates the link between Genetics and topics such as Computational biology that cross with problems in Small RNA, Methylation and Methyltransferase. RNA interference and Gene silencing are commonly linked in his work.

He most often published in these fields:

  • Cancer research (53.78%)
  • Cell biology (44.54%)
  • microRNA (41.18%)

What were the highlights of his more recent work (between 2017-2021)?

  • Cancer research (53.78%)
  • Bone marrow (19.33%)
  • Haematopoiesis (18.49%)

In recent papers he was focusing on the following fields of study:

The scientist’s investigation covers issues in Cancer research, Bone marrow, Haematopoiesis, Cell biology and Bone marrow failure. His study in Cancer research is interdisciplinary in nature, drawing from both Cell culture, Immunoprecipitation, Druggability, Car t cells and Multiple myeloma. Carl D. Novina interconnects Pathophysiology, MEDLINE and Bioinformatics in the investigation of issues within Bone marrow.

His Haematopoiesis study combines topics from a wide range of disciplines, such as CD34, Stromal cell and Blood cell. In his study, Oligonucleotide is inextricably linked to RNA, which falls within the broad field of Cell biology. His Bone marrow failure study deals with Progenitor cell intersecting with Cell, Homing and Cell cycle.

Between 2017 and 2021, his most popular works were:

  • On-chip recapitulation of clinical bone marrow toxicities and patient-specific pathophysiology. (49 citations)
  • On-chip recapitulation of clinical bone marrow toxicities and patient-specific pathophysiology. (49 citations)
  • The lncRNA SLNCR Recruits the Androgen Receptor to EGR1-Bound Genes in Melanoma and Inhibits Expression of Tumor Suppressor p21. (20 citations)

In his most recent research, the most cited papers focused on:

  • Gene
  • DNA
  • Gene expression

Carl D. Novina focuses on Cancer research, Long non-coding RNA, Melanoma, Bone marrow and Haematopoiesis. Cancer research and SBDS are two areas of study in which he engages in interdisciplinary research. His Long non-coding RNA study combines topics in areas such as Primer extension, Oligonucleotide and Cell biology.

His research integrates issues of Nucleic acid structure, Carcinogenesis, Psychological repression, Transcriptional regulation and EGR1 in his study of Melanoma. His Bone marrow research includes themes of Stromal cell, Cellular differentiation, Cell growth, Blood cell and Mesenchymal stem cell. His Haematopoiesis research integrates issues from Progenitor cell, CD34 and Cell.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

Killing the messenger: short RNAs that silence gene expression

Derek M. Dykxhoorn;Carl D. Novina;Phillip A. Sharp;Phillip A. Sharp.
Nature Reviews Molecular Cell Biology (2003)

1770 Citations

Lentivirus-delivered stable gene silencing by RNAi in primary cells.

Sheila A. Stewart;Derek M. Dykxhoorn;Deborah Palliser;Hana Mizuno.
RNA (2003)

1482 Citations

siRNA-directed inhibition of HIV-1 infection.

Carl D. Novina;Michael F. Murray;Derek M. Dykxhoorn;Paul J. Beresford.
Nature Medicine (2002)

1238 Citations

The RNAi revolution

Carl D. Novina;Phillip A. Sharp.
Nature (2004)

1038 Citations

Chronic lymphocytic leukemia requires BCL2 to sequester prodeath BIM, explaining sensitivity to BCL2 antagonist ABT-737

Victoria Del Gaizo Moore;Jennifer R. Brown;Michael Certo;Tara M. Love.
Journal of Clinical Investigation (2007)

668 Citations

Sustained Small Interfering RNA-Mediated Human Immunodeficiency Virus Type 1 Inhibition in Primary Macrophages

Erwei Song;Sang Kyung Lee;Derek M. Dykxhoorn;Carl Novina.
Journal of Virology (2003)

327 Citations

Cleaving the Oxidative Repair Protein Ape1 Enhances Cell Death Mediated by Granzyme A

Zusen Fan;Paul J. Beresford;Dong Zhang;Zhan Xu.
Nature Immunology (2003)

314 Citations

Intronic miR-211 assumes the tumor suppressive function of its host gene in melanoma.

Carmit Levy;Mehdi Khaled;Dimitrios Iliopoulos;Maja M. Janas;Maja M. Janas.
Molecular Cell (2010)

283 Citations

Core promoters and transcriptional control.

Carl D. Novina;Ananda L. Roy.
Trends in Genetics (1996)

258 Citations

Cloning of an Inr- and E-box-binding protein, TFII-I, that interacts physically and functionally with USF1

Ananda L. Roy;Ananda L. Roy;Hong Du;Hong Du;Polly D. Gregor;Polly D. Gregor;Carl D. Novina;Carl D. Novina.
The EMBO Journal (1997)

249 Citations

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