2014 - National Institutes of Health Director's Pioneer Award
Cell biology, Gene silencing, Transcription factor, Genetics and RNA interference are his primary areas of study. His research investigates the connection between Cell biology and topics such as Molecular biology that intersect with issues in AP site. The concepts of his Gene silencing study are interwoven with issues in Gene knockdown, Virology, Trans-acting siRNA, Messenger RNA and microRNA.
His work carried out in the field of Trans-acting siRNA brings together such families of science as DNA-directed RNA interference and Argonaute. His Transcription factor research is multidisciplinary, relying on both Transcription and Morphology. His study in the field of RNA silencing also crosses realms of Natural phenomenon.
Carl D. Novina mainly focuses on Cancer research, Cell biology, microRNA, Genetics and Molecular biology. Carl D. Novina combines subjects such as Haematopoiesis, Immunology, Bone marrow and Gene knockdown with his study of Cancer research. His Cell biology study integrates concerns from other disciplines, such as RNA, Psychological repression, Transcription and Argonaute.
His microRNA research is multidisciplinary, incorporating perspectives in Protein kinase B, Gene expression profiling, P-bodies, Protein biosynthesis and Messenger RNA. His research investigates the link between Genetics and topics such as Computational biology that cross with problems in Small RNA, Methylation and Methyltransferase. RNA interference and Gene silencing are commonly linked in his work.
The scientist’s investigation covers issues in Cancer research, Bone marrow, Haematopoiesis, Cell biology and Bone marrow failure. His study in Cancer research is interdisciplinary in nature, drawing from both Cell culture, Immunoprecipitation, Druggability, Car t cells and Multiple myeloma. Carl D. Novina interconnects Pathophysiology, MEDLINE and Bioinformatics in the investigation of issues within Bone marrow.
His Haematopoiesis study combines topics from a wide range of disciplines, such as CD34, Stromal cell and Blood cell. In his study, Oligonucleotide is inextricably linked to RNA, which falls within the broad field of Cell biology. His Bone marrow failure study deals with Progenitor cell intersecting with Cell, Homing and Cell cycle.
Carl D. Novina focuses on Cancer research, Long non-coding RNA, Melanoma, Bone marrow and Haematopoiesis. Cancer research and SBDS are two areas of study in which he engages in interdisciplinary research. His Long non-coding RNA study combines topics in areas such as Primer extension, Oligonucleotide and Cell biology.
His research integrates issues of Nucleic acid structure, Carcinogenesis, Psychological repression, Transcriptional regulation and EGR1 in his study of Melanoma. His Bone marrow research includes themes of Stromal cell, Cellular differentiation, Cell growth, Blood cell and Mesenchymal stem cell. His Haematopoiesis research integrates issues from Progenitor cell, CD34 and Cell.
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Killing the messenger: short RNAs that silence gene expression
Derek M. Dykxhoorn;Carl D. Novina;Phillip A. Sharp;Phillip A. Sharp.
Nature Reviews Molecular Cell Biology (2003)
Lentivirus-delivered stable gene silencing by RNAi in primary cells.
Sheila A. Stewart;Derek M. Dykxhoorn;Deborah Palliser;Hana Mizuno.
siRNA-directed inhibition of HIV-1 infection.
Carl D. Novina;Michael F. Murray;Derek M. Dykxhoorn;Paul J. Beresford.
Nature Medicine (2002)
The RNAi revolution
Carl D. Novina;Phillip A. Sharp.
Chronic lymphocytic leukemia requires BCL2 to sequester prodeath BIM, explaining sensitivity to BCL2 antagonist ABT-737
Victoria Del Gaizo Moore;Jennifer R. Brown;Michael Certo;Tara M. Love.
Journal of Clinical Investigation (2007)
Sustained Small Interfering RNA-Mediated Human Immunodeficiency Virus Type 1 Inhibition in Primary Macrophages
Erwei Song;Sang Kyung Lee;Derek M. Dykxhoorn;Carl Novina.
Journal of Virology (2003)
Cleaving the Oxidative Repair Protein Ape1 Enhances Cell Death Mediated by Granzyme A
Zusen Fan;Paul J. Beresford;Dong Zhang;Zhan Xu.
Nature Immunology (2003)
Intronic miR-211 assumes the tumor suppressive function of its host gene in melanoma.
Carmit Levy;Mehdi Khaled;Dimitrios Iliopoulos;Maja M. Janas;Maja M. Janas.
Molecular Cell (2010)
Core promoters and transcriptional control.
Carl D. Novina;Ananda L. Roy.
Trends in Genetics (1996)
Cloning of an Inr- and E-box-binding protein, TFII-I, that interacts physically and functionally with USF1
Ananda L. Roy;Ananda L. Roy;Hong Du;Hong Du;Polly D. Gregor;Polly D. Gregor;Carl D. Novina;Carl D. Novina.
The EMBO Journal (1997)
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