What is he best known for?
The fields of study he is best known for:
B de Crombrugghe mostly deals with Molecular biology, Promoter, Gene, Chondrocyte and Transcription factor.
The study incorporates disciplines such as Gene expression, DNA-binding protein, Rous sarcoma virus, Messenger RNA and Intron in addition to Molecular biology.
His study focuses on the intersection of Promoter and fields such as Transcription with connections in the field of Cell nucleus.
His Gene study is focused on Genetics in general.
As a part of the same scientific family, he mostly works in the field of Chondrocyte, focusing on Enhancer and, on occasion, Chondrogenesis and SOX9.
His Transcription factor study incorporates themes from Complementary DNA, Recombinant DNA, Saccharomyces cerevisiae and Cell biology.
His most cited work include:
- Some recent advances in the chemistry and biology of transforming growth factor-beta. (1187 citations)
- SOX9 is a potent activator of the chondrocyte-specific enhancer of the pro alpha1(II) collagen gene. (946 citations)
- Evidence for two functional gal promoters in intact Escherichia coli cells. (787 citations)
What are the main themes of his work throughout his whole career to date?
B de Crombrugghe mainly investigates Molecular biology, Gene, Promoter, Transcription and Genetically modified mouse.
His studies in Molecular biology integrate themes in fields like Nucleic acid sequence, DNA, Gene expression, Type I collagen and Complementary DNA.
His Gene research focuses on subjects like Cell biology, which are linked to Anatomy and Mutant.
As part of one scientific family, B de Crombrugghe deals mainly with the area of Promoter, narrowing it down to issues related to the Transcription factor, and often Binding site.
His studies deal with areas such as RNA, Restriction enzyme and RNA polymerase II as well as Transcription.
His work in Enhancer tackles topics such as SOX9 which are related to areas like Chondrocyte and Chondrogenesis.
He most often published in these fields:
- Molecular biology (60.80%)
- Gene (34.40%)
- Promoter (17.60%)
What were the highlights of his more recent work (between 1996-2015)?
- Cell biology (12.80%)
- Pathology (4.80%)
- Internal medicine (8.00%)
In recent papers he was focusing on the following fields of study:
B de Crombrugghe focuses on Cell biology, Pathology, Internal medicine, Enhancer and Chondrocyte.
His Cell biology research is multidisciplinary, incorporating elements of Fibrosis, Fibroblast, Gene and Anatomy.
His Gene study combines topics in areas such as Type I collagen, Type II collagen and Tight skin.
The Internal medicine study combines topics in areas such as Luciferase and Genetically modified mouse.
The concepts of his Enhancer study are interwoven with issues in SOX9 and Molecular biology.
In his study, which falls under the umbrella issue of Molecular biology, Gene expression, Transcription factor and Campomelic dysplasia is strongly linked to Chondrogenesis.
Between 1996 and 2015, his most popular works were:
- SOX9 is a potent activator of the chondrocyte-specific enhancer of the pro alpha1(II) collagen gene. (946 citations)
- L-Sox5, Sox6 and Sox9 control essential steps of the chondrocyte differentiation pathway. (288 citations)
- Osteoarthritis-like lesions in transgenic mice harboring a small deletion mutation in type II collagen gene. (64 citations)
In his most recent research, the most cited papers focused on:
His scientific interests lie mostly in Molecular biology, Chondrocyte, Enhancer, Pathology and Cartilage.
His Molecular biology course of study focuses on SOX9 and Activator, Transactivation and Enhancer RNAs.
His Chondrocyte research is multidisciplinary, incorporating perspectives in Procollagen peptidase, Type II collagen and Collagen, type I, alpha 1.
His Enhancer research is included under the broader classification of Gene.
The various areas that B de Crombrugghe examines in his Pathology study include Ossification, Osteocyte, Bone cell and Long bone.
His Cartilage research is multidisciplinary, relying on both Transcription factor and Gene expression.
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