The University of Texas MD Anderson Cancer Center
B de Crombrugghe mostly deals with Molecular biology, Promoter, Gene, Chondrocyte and Transcription factor. The study incorporates disciplines such as Gene expression, DNA-binding protein, Rous sarcoma virus, Messenger RNA and Intron in addition to Molecular biology. His study focuses on the intersection of Promoter and fields such as Transcription with connections in the field of Cell nucleus.
His Gene study is focused on Genetics in general. As a part of the same scientific family, he mostly works in the field of Chondrocyte, focusing on Enhancer and, on occasion, Chondrogenesis and SOX9. His Transcription factor study incorporates themes from Complementary DNA, Recombinant DNA, Saccharomyces cerevisiae and Cell biology.
B de Crombrugghe mainly investigates Molecular biology, Gene, Promoter, Transcription and Genetically modified mouse. His studies in Molecular biology integrate themes in fields like Nucleic acid sequence, DNA, Gene expression, Type I collagen and Complementary DNA. His Gene research focuses on subjects like Cell biology, which are linked to Anatomy and Mutant.
As part of one scientific family, B de Crombrugghe deals mainly with the area of Promoter, narrowing it down to issues related to the Transcription factor, and often Binding site. His studies deal with areas such as RNA, Restriction enzyme and RNA polymerase II as well as Transcription. His work in Enhancer tackles topics such as SOX9 which are related to areas like Chondrocyte and Chondrogenesis.
B de Crombrugghe focuses on Cell biology, Pathology, Internal medicine, Enhancer and Chondrocyte. His Cell biology research is multidisciplinary, incorporating elements of Fibrosis, Fibroblast, Gene and Anatomy. His Gene study combines topics in areas such as Type I collagen, Type II collagen and Tight skin.
The Internal medicine study combines topics in areas such as Luciferase and Genetically modified mouse. The concepts of his Enhancer study are interwoven with issues in SOX9 and Molecular biology. In his study, which falls under the umbrella issue of Molecular biology, Gene expression, Transcription factor and Campomelic dysplasia is strongly linked to Chondrogenesis.
His scientific interests lie mostly in Molecular biology, Chondrocyte, Enhancer, Pathology and Cartilage. His Molecular biology course of study focuses on SOX9 and Activator, Transactivation and Enhancer RNAs. His Chondrocyte research is multidisciplinary, incorporating perspectives in Procollagen peptidase, Type II collagen and Collagen, type I, alpha 1.
His Enhancer research is included under the broader classification of Gene. The various areas that B de Crombrugghe examines in his Pathology study include Ossification, Osteocyte, Bone cell and Long bone. His Cartilage research is multidisciplinary, relying on both Transcription factor and Gene expression.
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Some recent advances in the chemistry and biology of transforming growth factor-beta.
M B Sporn;A B Roberts;L M Wakefield;B de Crombrugghe.
Journal of Cell Biology (1987)
SOX9 is a potent activator of the chondrocyte-specific enhancer of the pro alpha1(II) collagen gene.
V Lefebvre;W Huang;V R Harley;P N Goodfellow.
Molecular and Cellular Biology (1997)
Evidence for two functional gal promoters in intact Escherichia coli cells.
H Aiba;S Adhya;B de Crombrugghe.
Journal of Biological Chemistry (1981)
Cyclic AMP receptor protein: role in transcription activation
B de Crombrugghe;S Busby;H Buc.
The Family of Collagen Genes
E Vuorio;B de Crombrugghe.
Annual Review of Biochemistry (1990)
L-Sox5, Sox6 and Sox9 control essential steps of the chondrocyte differentiation pathway.
V. Lefebvre;R. R. Behringer;B. De Crombrugghe.
Osteoarthritis and Cartilage (2001)
Levels of translatable mRNAs for cell surface protein, collagen precursors, and two membrane proteins are altered in Rous sarcoma virus-transformed chick embryo fibroblasts
S L Adams;M E Sobel;B H Howard;K Olden.
Proceedings of the National Academy of Sciences of the United States of America (1977)
Recombinant rat CBF-C, the third subunit of CBF/NFY, allows formation of a protein-DNA complex with CBF-A and CBF-B and with yeast HAP2 and HAP3.
Strajit Sinha;S. N. Maity;Jingfang Lu;B. De Crombrugghe.
Proceedings of the National Academy of Sciences of the United States of America (1995)
Separate cis-acting DNA elements of the mouse pro-alpha 1(I) collagen promoter direct expression of reporter genes to different type I collagen-producing cells in transgenic mice.
J Rossert;H Eberspaecher;B de Crombrugghe.
Journal of Cell Biology (1995)
Selective activation of transcription by a novel CCAAT binding factor
SN Maity;PT Golumbek;G Karsenty;B de Crombrugghe.
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